Beclomethasone dipropionate
Beconase, CHF 5993 Chiesi Farmaceutici S.p.A, Qnasl, Qvar, Riarify, Trimbow, Trydonis, Vancenase (beclomethasone dipropionate) is a small molecule pharmaceutical. Beclomethasone dipropionate was first approved as Beclovent on 1982-01-01. It is used to treat allergic rhinitis perennial and inflammation in the USA. It has been approved in Europe to treat chronic obstructive pulmonary disease. It is known to target adhesion G protein-coupled receptor G3.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Qnasl, Qvar (discontinued: Beclovent, Beconase, Qvar, Vancenase, Vanceril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Beclomethasone dipropionate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| QVAR REDIHALER | Norton Waterford | N-207921 RX | 2017-08-03 | 2 products, RLD |
| QNASL | Teva | N-202813 RX | 2012-03-23 | 2 products, RLD, RS |
Show 7 discontinued
Beclomethasone dipropionate monohydrate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BECONASE AQ | GSK | N-019389 DISCN | 1987-07-27 | 1 products, RLD |
| VANCENASE AQ | Merck & Co | N-019589 DISCN | 1987-12-23 | 1 products |
| VANCENASE AQ | Merck & Co | N-020469 DISCN | 1996-06-26 | 1 products |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| 5 in 1 clipper spry | OTC monograph not final | 2020-10-16 |
| beconase | New Drug Application | 2021-02-09 |
| beconase aq | New Drug Application | 2009-10-27 |
| beconase aq | 2006-10-06 | |
| qnasl | New Drug Application | 2022-09-27 |
| qvar | New Drug Application | 2018-08-31 |
| qvar redihaler | New Drug Application | 2024-06-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| inflammation | MP_0001845 | D007249 | — |
| allergic rhinitis perennial | EFO_1001417 | D012221 | J30.89 |
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Beclomethasone Dipropionate, Qvar Redihaler, Norton Waterford | |||
| 11583643 | 2041-08-19 | DP | |
| 11559637 | 2039-07-21 | DP | |
| 10792447 | 2039-01-25 | DP | |
| 11395888 | 2038-01-26 | DP | |
| 11793953 | 2038-01-26 | DP | |
| 11865247 | 2038-01-26 | DP | |
| 8931476 | 2031-07-17 | DP | |
| 8132712 | 2028-09-07 | DP | |
| Beclomethasone Dipropionate, Qvar 40, Teva Branded Pharm | |||
| 10561808 | 2032-01-01 | DP | |
| 9463289 | 2031-05-18 | DP | |
| 9808587 | 2031-05-18 | DP | |
| 10022509 | 2031-05-18 | DP | |
| 10022510 | 2031-05-18 | DP | |
| 10086156 | 2031-05-18 | DP | |
| 10695512 | 2031-05-18 | DP | |
| 11395889 | 2031-05-18 | DP | |
| Beclomethasone Dipropionate, Qnasl, Teva Branded Pharm | |||
| 10188811 | 2031-10-21 | DP | |
| 7780038 | 2027-01-24 | DP | |
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07E: Intestinal antiinflammatory agents
— A07EA: Corticosteroids acting locally
— A07EA07: Beclometasone
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC15: Beclometasone
— D07C: Corticosteroids, combinations with antibiotics
— D07CC: Corticosteroids, potent, combinations with antibiotics
— D07CC04: Beclometasone and antibiotics
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AD: Corticosteroid nasal preparations for topical use
— R01AD01: Beclometasone
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics
— R03AK08: Formoterol and beclometasone
— R03AK13: Salbutamol and beclometasone
— R03AL: Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
— R03AL09: Formoterol, glycopyrronium bromide and beclometasone
— R03B: Other drugs for obstructive airway diseases, inhalants in atc
— R03BA: Glucocorticoid inhalants for obstructive airway disease
— R03BA01: Beclometasone
HCPCS
No data
Clinical
Clinical Trials
245 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | 6 | 27 | 46 | 23 | 30 | 128 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 7 | 4 | 14 | 10 | 19 | 53 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | 4 | 1 | 12 | 8 | 11 | 36 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | 1 | 14 | 7 | 5 | 27 |
| Allergic rhinitis | D065631 | — | J30.9 | 2 | 3 | 12 | 3 | 4 | 23 |
| Rhinitis | D012220 | EFO_0008521 | J31 | 2 | 3 | 12 | 3 | 4 | 23 |
| Allergic rhinitis seasonal | D006255 | EFO_0003956 | J30 | 1 | 3 | 4 | 1 | — | 8 |
| Respiratory sounds | D012135 | HP_0010307 | R06.1 | — | — | 1 | 3 | — | 4 |
| Respiratory tract diseases | D012140 | — | — | — | — | 2 | 1 | — | 3 |
| Respiratory hypersensitivity | D012130 | — | — | — | 1 | 1 | 1 | — | 3 |
Show 19 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Graft vs host disease | D006086 | — | D89.81 | 1 | 4 | 3 | — | 1 | 8 |
| Allergic rhinitis perennial | D012221 | EFO_1001417 | J30.89 | — | — | 6 | — | 2 | 8 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | 1 | — | 1 | — | 1 | 3 |
| Bronchopulmonary dysplasia | D001997 | — | P27.8 | — | 1 | 1 | — | 1 | 3 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | 1 | — | — | 2 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | — | — | 1 | — | — | 1 |
| Rhinosinusitis | D000096825 | — | — | — | — | 1 | — | — | 1 |
| Folliculitis | D005499 | — | — | — | 1 | 1 | — | — | 1 |
| Croup | D003440 | EFO_0007227 | J05.0 | — | — | 1 | — | — | 1 |
| Laryngitis | D007827 | — | — | — | — | 1 | — | — | 1 |
Show 1 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | 1 | 2 | — | — | 3 | 5 |
| Communicable diseases | D003141 | — | — | 1 | 1 | — | — | 3 | 4 |
| Covid-19 | D000086382 | — | — | 1 | 2 | — | — | — | 3 |
| Leukemia | D007938 | — | C95 | 1 | 2 | — | — | — | 2 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 2 | — | — | — | 2 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 1 | 2 | — | — | — | 2 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 2 | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 1 | 2 | — | — | — | 2 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 2 | — | — | — | 2 |
| Preleukemia | D011289 | — | — | 1 | 2 | — | — | — | 2 |
Show 65 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | — | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Eosinophilic esophagitis | D057765 | EFO_0004232 | K20.0 | 1 | — | — | — | — | 1 |
| Esophagitis | D004941 | HP_0100633 | K20 | 1 | — | — | — | — | 1 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | 1 | — | — | — | — | 1 |
| Acute lung injury | D055371 | EFO_0004610 | — | 1 | — | — | — | — | 1 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | 1 | — | — | — | — | 1 |
| Bronchiolitis | D001988 | HP_0011950 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Surgical wound infection | D013530 | — | — | — | — | — | — | 2 | 2 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | — | — | 1 | 1 |
| Colitis | D003092 | EFO_0003872 | K52.9 | — | — | — | — | 1 | 1 |
| Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
| Smoking | D012907 | EFO_0004318 | — | — | — | — | — | 1 | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 1 | 1 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | — | — | 1 | 1 |
| Intraocular pressure | D007429 | — | — | — | — | — | — | 1 | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 1 | 1 |
Show 11 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Beclomethasone dipropionate |
| INN | beclometasone |
| Description | Beclomethasone dipropionate is a steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions. It has a role as an anti-inflammatory drug, an anti-asthmatic drug, a prodrug and an anti-arrhythmia drug. It is a steroid ester, an enone, a 20-oxo steroid, an 11beta-hydroxy steroid, a propanoate ester, a corticosteroid, a glucocorticoid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid. It is functionally related to a beclomethasone. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C |
Identifiers
| PDB | — |
| CAS-ID | 5534-09-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200500 |
| ChEBI ID | 3002 |
| PubChem CID | 21700 |
| DrugBank | DB00394 |
| UNII ID | KGZ1SLC28Z (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
ADGRG3
ADGRG3
Organism
Homo sapiens
Gene name
ADGRG3
Gene synonyms
GPR97, PGR26
NCBI Gene ID
Protein name
adhesion G protein-coupled receptor G3
Protein synonyms
G protein-coupled receptor 97, G-protein coupled receptor 97, G-protein coupled receptor PGR26, probable G-protein coupled receptor 97
Uniprot ID
Mouse ortholog
Adgrg3 (54672)
adhesion G protein-coupled receptor G3 (Q8R0T6)
Variants
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Financial
Revenue by drug
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Qvar – Teva
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Estimated US medical usage
Beclomethasone dipropionate
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Beclomethasone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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8,179 adverse events reported
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