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Drug ReportsBazedoxifene
Duavee, Conbriza(bazedoxifene)
Conbriza, Duavee, Duavive (bazedoxifene) is a small molecule pharmaceutical. Bazedoxifene was first approved as Conbriza on 2009-04-17. It is used to treat menopause in the USA. It has been approved in Europe to treat postmenopausal osteoporosis and postmenopause. The pharmaceutical is active against estrogen receptor beta and estrogen receptor.
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Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nutritional and metabolic diseasesD009750
reproductive and urinary physiological phenomenaD012101
Trade Name
FDA
EMA
Combinations
Duavee
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bazedoxifene acetate
+
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
DUAVEEWyethN-022247 RX2013-10-03
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
duaveeNew Drug Application2025-01-13
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
menopauseEFO_0003922D008593N95
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bazedoxifene Acetate / Estrogens, Conjugated, Duavee, Wyeth Pharms
76830512027-03-10DS, DPU-594, U-904
64795352024-05-06DPU-594, U-904
ATC Codes
G: Genito urinary system and sex hormones
— G03: Sex hormones and modulators of the genital system
— G03C: Estrogens, sex hormones and modulators of the genital system
— G03CC: Estrogens, combinations with other drugs
— G03CC07: Conjugated estrogens and bazedoxifene
— G03X: Other sex hormones and modulators of the genital system in atc
— G03XC: Selective estrogen receptor modulators
— G03XC02: Bazedoxifene
HCPCS
No data
Clinical
Clinical Trials
58 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.0——3148
Postmenopausal osteoporosisD015663EFO_0003854————112
Rheumatoid arthritisD001172EFO_0000685M06.9———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MenopauseD008593EFO_0003922N951—1——2
Endometrial hyperplasiaD004714—N85.0——1——1
HyperplasiaD006965EFO_0000536———1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5013———3
CarcinomaD002277—C80.0—1———1
Carcinoma in situD002278—D09.9—1———1
Breast carcinoma in situD000071960—D05—1———1
Ductal carcinoma breastD018270———1———1
Intraductal carcinoma noninfiltratingD002285—D05.1—1———1
PostmenopauseD017698———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Anxiety disordersD001008EFO_0006788F41.11————1
SleepD012890GO_0030431—1————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBazedoxifene
INNbazedoxifene
Description
Bazedoxifene is a phenylindole.
Classification
Small molecule
Drug classantiestrogens of the clomifene and tamoxifen groups
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
Identifiers
PDB—
CAS-ID198481-32-2
RxCUI—
ChEMBL IDCHEMBL46740
ChEBI ID—
PubChem CID154257
DrugBankDB06401
UNII IDQ16TT9C5BK (ChemIDplus, GSRS)
Target
Agency Approved
ESR2
ESR2
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Alternate
No data
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,351 documents
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Safety
Black-box Warning
Black-box warning for: Duavee
Adverse Events
Top Adverse Reactions
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1,017 adverse events reported
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