Basimglurant
Basimglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target metabotropic glutamate receptor 5.
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Commercial
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neuralgia | D009437 | EFO_0009430 | — | — | 1 | 1 | — | — | 1 |
| Trigeminal neuralgia | D014277 | EFO_1001219 | G50.0 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 1 | 2 | — | — | — | 3 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | — | — | — | 3 |
| Fragile x syndrome | D005600 | — | Q99.2 | — | 3 | — | — | — | 3 |
| Syndrome | D013577 | — | — | — | 3 | — | — | — | 3 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | — | 2 |
| Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | — | — | 1 |
| Tuberous sclerosis | D014402 | — | Q85.1 | — | 1 | — | — | — | 1 |
| Sclerosis | D012598 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Basimglurant |
| INN | basimglurant |
| Description | Basimglurant (INN) (developmental code names RG-7090, RO-4917523) is a negative allosteric modulator of the mGlu5 receptor which is under development by Roche and Chugai Pharmaceutical for the treatment of treatment-resistant depression (as an adjunct) and fragile X syndrome. As of November 2016, it has undergone phase II clinical trials for both of these indications.
|
| Classification | Small molecule |
| Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 1034442-21-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301626 |
| ChEBI ID | — |
| PubChem CID | 11438771 |
| DrugBank | DB11833 |
| UNII ID | 3110E3AO8S (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
GRM5
GRM5
Variants
No data
Financial
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Trends
PubMed Central
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Additional graphs summarizing 255 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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