Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Depression | D003863 | — | F33.9 | 1 | 2 | — | — | — | 3 |
Depressive disorder | D003866 | EFO_1002014 | F32.A | 1 | 2 | — | — | — | 3 |
Fragile x syndrome | D005600 | — | Q99.2 | — | 3 | — | — | — | 3 |
Syndrome | D013577 | — | — | — | 3 | — | — | — | 3 |
Major depressive disorder | D003865 | EFO_0003761 | F22 | 1 | 1 | — | — | — | 2 |
Treatment-resistant depressive disorder | D061218 | — | — | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 7 | — | — | — | — | 7 |
Drug common name | Basimglurant |
INN | basimglurant |
Description | Basimglurant (INN) (developmental code names RG-7090, RO-4917523) is a negative allosteric modulator of the mGlu5 receptor which is under development by Roche and Chugai Pharmaceutical for the treatment of treatment-resistant depression (as an adjunct) and fragile X syndrome. As of November 2016, it has undergone phase II clinical trials for both of these indications.
|
Classification | Small molecule |
Drug class | metabotropic glutamate receptor antagonists, negative allosteric modulators |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1 |
PDB | — |
CAS-ID | 1034442-21-1 |
RxCUI | — |
ChEMBL ID | CHEMBL3301626 |
ChEBI ID | — |
PubChem CID | 11438771 |
DrugBank | — |
UNII ID | 3110E3AO8S (ChemIDplus, GSRS) |