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Drug ReportsBasimglurant
Basimglurant
Basimglurant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target metabotropic glutamate receptor 5.
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Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
DepressionD003863F33.9123
Depressive disorderD003866EFO_1002014F32.A123
Fragile x syndromeD005600Q99.233
SyndromeD01357733
Major depressive disorderD003865EFO_0003761F22112
Treatment-resistant depressive disorderD06121811
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients77
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBasimglurant
INNbasimglurant
Description
Basimglurant (INN) (developmental code names RG-7090, RO-4917523) is a negative allosteric modulator of the mGlu5 receptor which is under development by Roche and Chugai Pharmaceutical for the treatment of treatment-resistant depression (as an adjunct) and fragile X syndrome. As of November 2016, it has undergone phase II clinical trials for both of these indications.
Classification
Small molecule
Drug classmetabotropic glutamate receptor antagonists, negative allosteric modulators
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Structure (InChI/SMILES or Protein Sequence)
Cc1nc(C#Cc2ccnc(Cl)c2)c(C)n1-c1ccc(F)cc1
Identifiers
PDB
CAS-ID1034442-21-1
RxCUI
ChEMBL IDCHEMBL3301626
ChEBI ID
PubChem CID11438771
DrugBank
UNII ID3110E3AO8S (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GRM5
GRM5
Organism
Homo sapiens
Gene name
GRM5
Gene synonyms
GPRC1E, MGLUR5
NCBI Gene ID
Protein name
metabotropic glutamate receptor 5
Protein synonyms
glutamate receptor, metabotropic 5, protein phosphatase 1, regulatory subunit 86
Uniprot ID
Mouse ortholog
Grm5 (108071)
metabotropic glutamate receptor 5 (Q3UVX5)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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