Simulect(basiliximab)
Simulect (basiliximab) is an antibody pharmaceutical. Basiliximab was first approved as Simulect on 1998-05-12. It has been approved in Europe to treat graft rejection and kidney transplantation. It is known to target interleukin-2 receptor subunit alpha.
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Commercial
Trade Name
FDA
EMA
Simulect
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Basiliximab
Tradename
Proper name
Company
Number
Date
Products
SimulectbasiliximabNovartisN-103764 RX1998-05-12
2 products
Labels
FDA
EMA
Brand Name
Status
Last Update
simulectBiologic Licensing Application2025-01-21
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
Expiration
Code
basiliximab, Simulect, Novartis Pharmaceuticals Corporation
2105-05-12Orphan excl.
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
L04: Immunosuppressants
L04A: Immunosuppressants
L04AC: Interleukin inhibitors
L04AC02: Basiliximab
HCPCS
Code
Description
J0480
Injection, basiliximab, 20 mg
Clinical
Clinical Trials
163 clinical trials
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Organ transplantationD01637722
FibrosisD00535511
Interstitial lung diseasesD017563EFO_0004244J84.911
Hepatitis cD006526B19.211
HepatitisD006505K75.911
Graft rejectionD00608411
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.911
EmphysemaD004646EFO_0000464J4311
Bronchiolitis obliteransD001989EFO_0007183J44.8111
BronchiolitisD00198811
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Virus diseasesD014777B3411
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetes mellitusD003920EFO_0000400E08-E1311
Immunosuppression therapyD00716511
Polyomavirus infectionsD027601EFO_000745111
ViremiaD014766B34.911
Graft vs host diseaseD006086D89.8111
Hematopoietic stem cell transplantationD01838011
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBasiliximab
INNbasiliximab
Description
Basiliximab (chimeric mab)
Classification
Antibody
Drug classmonoclonal antibodies
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
>3IU3:A,C,H|Heavy chain of Fab fragment of Basiliximab QLQQSGTVLARPGASVKMSCKASGYSFTRYWMHWIKQRPGQGLEWIGAIYPGNSDTSYNQKFEGKAKLTAVTSASTAYME LSSLTHEDSAVYYCSRDYGYYFDFWGQGTTLTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGA LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEP >3IU3:B,D,L|Light chain of Fab fragment of Basiliximab QIVSTQSPAIMSASPGEKVTMTCSASSSRSYMQWYQQKPGTSPKRWIYDTSKLASGVPARFSGSGSGTSYSLTISSMEAE DAATYYCHQRSSYTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE
Identifiers
PDB3IU3
CAS-ID
RxCUI
ChEMBL IDCHEMBL1201439
ChEBI ID
PubChem CID
DrugBankDB00074
UNII ID9927MT646M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
IL2RA
IL2RA
Organism
Homo sapiens
Gene name
IL2RA
Gene synonyms
NCBI Gene ID
Protein name
interleukin-2 receptor subunit alpha
Protein synonyms
CD25, IL-2 receptor subunit alpha, IL-2R subunit alpha, interleukin 2 receptor, alpha, p55, TAC antigen
Uniprot ID
Mouse ortholog
Il2ra (16184)
interleukin-2 receptor subunit alpha (Q61731)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,645 documents
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Safety
Black-box Warning
Black-box warning for: Simulect
Adverse Events
Top Adverse Reactions
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8,347 adverse events reported
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