Brand Name | Status | Last Update |
---|---|---|
baricitinib | Use Authorization | 2022-05-10 |
olumiant | New Drug Application | 2024-11-13 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
Expiration | Code | ||
---|---|---|---|
BARICITINIB, OLUMIANT, ELI LILLY AND CO | |||
2025-06-13 | I-890 | ||
2025-05-10 | I-891 | ||
2023-05-31 | NCE |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 2 | 10 | 3 | — | 15 |
Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 2 | 7 | 3 | — | 13 |
Alopecia areata | D000506 | EFO_0004192 | L63 | — | 2 | 3 | 1 | — | 5 |
Alopecia | D000505 | — | L64 | — | 2 | 3 | 1 | — | 5 |
Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | 1 | — | 1 |
Spondylarthritis | D025241 | — | — | — | — | — | 1 | — | 1 |
Spondylitis | D013166 | — | M46.9 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Atopic dermatitis | D003876 | EFO_0000274 | L20 | — | 1 | 8 | — | 1 | 10 |
Eczema | D004485 | — | L30.9 | — | 1 | 8 | — | 1 | 10 |
Dermatitis | D003872 | — | L30.9 | — | 1 | 8 | — | 1 | 10 |
Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | 1 | 3 | — | — | 4 |
Skin diseases | D012871 | — | L00-L99 | — | 2 | 2 | — | 1 | 4 |
Syndrome | D013577 | — | — | — | 3 | 1 | — | 1 | 4 |
Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 3 | — | — | 3 |
Fever | D005334 | — | R50.9 | — | 1 | 1 | — | 1 | 2 |
Lipodystrophy | D008060 | — | E88.1 | — | 1 | 1 | — | 1 | 2 |
Hyperthermia | D000084462 | — | — | — | 1 | 1 | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | 2 | — | — | — | 2 |
Polymyalgia rheumatica | D011111 | EFO_0008518 | M35.3 | — | 2 | — | — | — | 2 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | 2 | — | — | — | 2 |
Myositis | D009220 | EFO_0000783 | G72.49 | — | 1 | — | — | — | 1 |
Muscular diseases | D009135 | EFO_0002970 | G72.9 | — | 1 | — | — | — | 1 |
Autoimmune diseases of the nervous system | D020274 | — | — | — | 1 | — | — | — | 1 |
Nervous system malformations | D009421 | — | Q00-Q07 | — | 1 | — | — | — | 1 |
Biliary liver cirrhosis | D008105 | — | K74.3 | — | 1 | — | — | — | 1 |
Cholangitis | D002761 | HP_0030151 | K83.0 | — | 1 | — | — | — | 1 |
Arteritis | D001167 | EFO_0009011 | I77.6 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 15 | — | — | — | — | 15 |
Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Dermatomyositis | D003882 | EFO_0000398 | M33 | — | — | — | — | 1 | 1 |
Drug common name | Baricitinib |
INN | baricitinib |
Description | Baricitinib is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis. It has a role as an antirheumatic drug, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an anti-inflammatory agent, an immunosuppressive agent and an antiviral agent. It is a pyrrolopyrimidine, a member of pyrazoles, a member of azetidines, a sulfonamide and a nitrile. |
Classification | Small molecule |
Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 |
PDB | — |
CAS-ID | 1187594-09-7 |
RxCUI | — |
ChEMBL ID | CHEMBL2105759 |
ChEBI ID | — |
PubChem CID | 44205240 |
DrugBank | DB11817 |
UNII ID | ISP4442I3Y (ChemIDplus, GSRS) |