Olumiant(baricitinib)
Baricitinib, Olumiant (baricitinib) is a small molecule pharmaceutical. Baricitinib was first approved as Olumiant on 2017-02-13. It is used to treat rheumatoid arthritis in the USA. It has been approved in Europe to treat rheumatoid arthritis. The pharmaceutical is active against tyrosine-protein kinase JAK1 and tyrosine-protein kinase JAK2. In addition, it is known to target cyclin-G-associated kinase, non-receptor tyrosine-protein kinase TYK2, BMP-2-inducible protein kinase, AP2-associated protein kinase 1, and tyrosine-protein kinase JAK3.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Olumiant (discontinued: Baricitinib)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| baricitinib | Use Authorization | 2022-05-10 |
| olumiant | New Drug Application | 2026-06-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| rheumatoid arthritis | EFO_0000685 | D001172 | M06.9 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
BARICITINIB, OLUMIANT, ELI LILLY AND CO | |||
| 2025-06-13 | I-890 | ||
| 2025-05-10 | I-891 | ||
| 2023-05-31 | NCE | ||
HCPCS
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Clinical
Clinical Trials
196 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | 1 | 4 | 11 | 10 | 12 | 38 |
| Covid-19 | D000086382 | — | U07.1 | — | 8 | 17 | 1 | 5 | 27 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | 3 | 7 | 4 | 7 | 21 |
| Atopic dermatitis | D003876 | EFO_0000274 | L20 | 1 | 1 | 8 | 1 | 7 | 18 |
| Eczema | D004485 | — | L30.9 | — | 1 | 8 | 1 | 3 | 13 |
| Dermatitis | D003872 | — | L30.9 | 1 | 1 | 5 | 1 | 3 | 11 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | 1 | 1 | 2 |
| Spondylarthritis | D025241 | — | — | — | 1 | — | 1 | — | 2 |
| Spondylitis | D013166 | — | M46.9 | — | 1 | — | 1 | — | 2 |
| Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 5 | 5 | — | — | 8 |
| Alopecia areata | D000506 | EFO_0004192 | L63 | 2 | 2 | 3 | — | 2 | 8 |
| Alopecia | D000505 | — | L64 | 1 | 3 | 1 | — | 1 | 6 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | 1 | 3 | — | — | 5 |
| Skin diseases | D012871 | — | L00-L99 | — | 3 | 2 | — | 1 | 5 |
| Syndrome | D013577 | — | — | 1 | 3 | 1 | — | 2 | 5 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 2 | 2 | — | — | 4 |
| Dermatomyositis | D003882 | EFO_0000398 | M33 | — | 2 | 1 | — | 1 | 4 |
| Juvenile arthritis | D001171 | EFO_1002007 | M08 | — | — | 3 | — | — | 3 |
| Vitiligo | D014820 | EFO_0004208 | L80 | — | 2 | 1 | — | 1 | 3 |
Show 40 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | O98.7 | — | 4 | — | — | — | 4 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | — | 4 | — | — | — | 4 |
| Depression | D003863 | — | F33.9 | — | 2 | — | — | 1 | 3 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 3 | — | — | — | 3 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 3 | — | — | — | 3 |
| Cognitive dysfunction | D060825 | — | G31.84 | 1 | 1 | — | — | 1 | 2 |
| Myositis | D009220 | EFO_0000783 | G72.49 | — | 2 | — | — | — | 2 |
| Muscular diseases | D009135 | EFO_0002970 | G72.9 | — | 2 | — | — | — | 2 |
| Graft vs host disease | D006086 | — | D89.81 | 2 | 1 | — | — | — | 2 |
| Giant cell arteritis | D013700 | EFO_1001209 | M31.6 | — | 2 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 18 | — | — | — | — | 18 |
| Allergic contact dermatitis | D017449 | — | L23 | 1 | — | — | — | — | 1 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Contact dermatitis | D003877 | — | L25 | 1 | — | — | — | — | 1 |
| Delayed hypersensitivity | D006968 | — | — | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Liver failure | D017093 | — | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| Chondrosarcoma | D002813 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Joint diseases | D007592 | — | M12.9 | — | — | — | — | 1 | 1 |
| Musculoskeletal diseases | D009140 | — | — | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Brain diseases | D001927 | — | G93.40 | — | — | — | — | 1 | 1 |
| Fatigue | D005221 | — | R53.83 | — | — | — | — | 1 | 1 |
| Rheumatic diseases | D012216 | — | M79.0 | — | — | — | — | 1 | 1 |
| Ankylosing spondylitis | D013167 | EFO_0003898 | M45 | — | — | — | — | 1 | 1 |
| Eosinophilia | D004802 | — | D72.1 | — | — | — | — | 1 | 1 |
| Immunoglobulin g4-related disease | D000077733 | — | D89.84 | — | — | — | — | 1 | 1 |
| Autoimmune diseases of the nervous system | D020274 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Baricitinib |
| INN | baricitinib |
| Description | Baricitinib is a pyrrolopyrimidine that is 7H-pyrrolo[2,3-d]pyrimidine substituted by a 1-[3-(cyanomethyl)-1-(ethanesulfonyl)azetidin-3-yl]-1H-pyrazol-4-yl group at position 5. It is an FDA approved selective Janus Kinase 1 and 2 (JAK1 and JAK2) inhibitor used for the treatment of rheumatoid arthritis. It has a role as an antirheumatic drug, an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor, an anti-inflammatory agent, an immunosuppressive agent and an antiviral agent. It is a pyrrolopyrimidine, a member of pyrazoles, a member of azetidines, a sulfonamide and a nitrile. |
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors: tyrosine kinase inhibitors; janus kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCS(=O)(=O)N1CC(CC#N)(n2cc(-c3ncnc4[nH]ccc34)cn2)C1 |
Identifiers
| PDB | — |
| CAS-ID | 1187594-09-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105759 |
| ChEBI ID | — |
| PubChem CID | 44205240 |
| DrugBank | DB11817 |
| UNII ID | ISP4442I3Y (ChemIDplus, GSRS) |
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Safety
Black-box Warning
Black-box warning for: Olumiant
Adverse Events
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8,660 adverse events reported
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