Bardoxolone
Bardoxolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target peroxisome proliferator-activated receptor gamma and kelch-like ECH-associated protein 1.
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Events Timeline
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YTD
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Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
33 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | 3 | 4 | 2 | — | — | 9 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | 4 | 1 | — | — | 8 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 3 | 1 | — | — | 4 |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 1 | 2 | — | — | 3 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | 2 | — | — | 3 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | 1 | 2 | — | — | 3 |
| Hereditary nephritis | D009394 | EFO_0004128 | Q87.81 | — | 1 | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 1 | — | — | — | 1 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | — | 1 | — | — | — | 1 |
| Interstitial lung diseases | D017563 | EFO_0004244 | J84.9 | — | 1 | — | — | — | 1 |
| Cryptogenic organizing pneumonia | D018549 | EFO_1001300 | J84.116 | — | 1 | — | — | — | 1 |
| Idiopathic interstitial pneumonias | D054988 | — | — | — | 1 | — | — | — | 1 |
| Hamman-rich syndrome | D000080203 | — | J84.11 | — | 1 | — | — | — | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | 1 | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
| Focal segmental glomerulosclerosis | D005923 | EFO_0004236 | — | — | 1 | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | 1 | — | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Bardoxolone |
| INN | bardoxolone |
| Description | Bardoxolone methyl is a member of cyclohexenones. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1 |
Identifiers
| PDB | — |
| CAS-ID | 218600-44-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1093059 |
| ChEBI ID | — |
| PubChem CID | 400769 |
| DrugBank | DB12651 |
| UNII ID | 7HT68L8941 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PPARG
PPARG
KEAP1
KEAP1
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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