Bardoxolone
Bardoxolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target peroxisome proliferator-activated receptor gamma and kelch-like ECH-associated protein 1.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
No data
Commercial
No data
Clinical
No data
Drug
General
| Drug common name | Bardoxolone |
| INN | bardoxolone |
| Description | Bardoxolone methyl is a member of cyclohexenones. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1 |
Identifiers
| PDB | — |
| CAS-ID | 218600-44-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1093059 |
| ChEBI ID | — |
| PubChem CID | 400769 |
| DrugBank | DB12651 |
| UNII ID | 7HT68L8941 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PPARG
PPARG
KEAP1
KEAP1
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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