BRILACIDIN
Brilacidin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Staphylococcal infections | D013203 | — | A49.01 | — | 2 | — | — | — | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | 1 | — | — | — | 1 |
| Bacterial infections | D001424 | — | A49 | — | 1 | — | — | — | 1 |
| Infectious skin diseases | D012874 | — | — | — | 1 | — | — | — | 1 |
| Wound infection | D014946 | — | — | — | 1 | — | — | — | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | 1 | — | — | — | 1 |
| Cellulitis | D002481 | EFO_0003035 | L03.90 | — | 1 | — | — | — | 1 |
| Erysipelas | D004886 | — | A46 | — | 1 | — | — | — | 1 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BRILACIDIN |
| INN | brilacidin |
| Description | Brilacidin (formerly PMX-30063), an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs). HDPs, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life. As brilacidin is modeled after a defensin, it is also called a defensin mimetic.
|
| Classification | Small molecule |
| Drug class | natural antibiotics (undefined group) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N=C(N)NCCCCC(=O)Nc1cc(C(F)(F)F)cc(NC(=O)c2cc(C(=O)Nc3cc(C(F)(F)F)cc(NC(=O)CCCCNC(=N)N)c3O[C@@H]3CCNC3)ncn2)c1O[C@@H]1CCNC1 |
Identifiers
| PDB | — |
| CAS-ID | 1224095-98-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2219413 |
| ChEBI ID | — |
| PubChem CID | 25023695 |
| DrugBank | — |
| UNII ID | I1679X069H (ChemIDplus, GSRS) |
Target
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Trends
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Safety
Black-box Warning
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Adverse Events
0 adverse events reported
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