BIRINAPANT
Birinapant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against baculoviral IAP repeat-containing protein 2. In addition, it is known to target E3 ubiquitin-protein ligase XIAP.
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EMA approval date
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Study first post date
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Commercial
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 5 | 4 | — | — | — | 7 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 2 | 3 | — | — | — | 4 |
| Fallopian tube neoplasms | D005185 | — | — | 2 | 3 | — | — | — | 4 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 2 | 3 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 2 | 2 | — | — | — | 3 |
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 3 | — | — | — | 3 |
| Preleukemia | D011289 | — | — | 1 | 2 | — | — | — | 2 |
| Syndrome | D013577 | — | — | 1 | 2 | — | — | — | 2 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 1 | — | — | — | 2 |
| Recurrence | D012008 | — | — | 2 | 1 | — | — | — | 2 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | — | 1 |
| Sarcoma | D012509 | — | — | 1 | — | — | — | — | 1 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | — | — | — | — | 1 |
| Chondrosarcoma | D002813 | — | — | 1 | — | — | — | — | 1 |
| Hepatitis b | D006509 | — | — | 1 | — | — | — | — | 1 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 1 | — | — | — | — | 1 |
| Hepatitis | D006505 | — | K75.9 | 1 | — | — | — | — | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | 1 | — | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BIRINAPANT |
| INN | birinapant |
| Description | Birinapant is a dipeptide. |
| Classification | Small molecule |
| Drug class | inhibitor of apoptosis protein (IAP) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c(-c2[nH]c3cc(F)ccc3c2C[C@@H]2C[C@H](O)CN2C(=O)[C@H](CC)NC(=O)[C@H](C)NC)[nH]c2cc(F)ccc12 |
Identifiers
| PDB | — |
| CAS-ID | 1260251-31-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3039522 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11782 |
| UNII ID | 6O4Z07B57R (ChemIDplus, GSRS) |
Target
Agency Approved
BIRC2
BIRC2
Organism
Homo sapiens
Gene name
BIRC2
Gene synonyms
API1, MIHB, RNF48
NCBI Gene ID
Protein name
baculoviral IAP repeat-containing protein 2
Protein synonyms
apoptosis inhibitor 1, C-IAP1, Cellular inhibitor of apoptosis 1, hIAP-2, hIAP2, IAP homolog B, IAP-2, Inhibitor of apoptosis protein 2, NFR2-TRAF signalling complex protein, RING finger protein 48, RING-type E3 ubiquitin transferase BIRC2, TNFR2-TRAF-signaling complex protein 2
Uniprot ID
Mouse ortholog
Birc2 (11797)
baculoviral IAP repeat-containing protein 2 (Q62210)
Alternate
XIAP
XIAP
Organism
Homo sapiens
Gene name
XIAP
Gene synonyms
API3, BIRC4, IAP3
NCBI Gene ID
Protein name
E3 ubiquitin-protein ligase XIAP
Protein synonyms
Baculoviral IAP repeat-containing protein 4, hIAP-3, hIAP3, hILP, IAP-3, IAP-like protein, IAP-like protein 1, ILP, Inhibitor of apoptosis protein 3, RING-type E3 ubiquitin transferase XIAP, X-linked IAP, X-linked inhibitor of apoptosis protein, X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Uniprot ID
Mouse ortholog
Xiap (11798)
E3 ubiquitin-protein ligase XIAP (Q60989)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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