BELVARAFENIB
Belvarafenib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target RAF proto-oncogene serine/threonine-protein kinase and serine/threonine-protein kinase B-raf.
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Commercial
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Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BELVARAFENIB |
| INN | belvarafenib |
| Description | Belvarafenib (developed by Hanmi Pharmaceuticals and Genentech) is a small molecule RAF dimer (type II) inhibitor which shows anti-tumor clinical activity in cancer patients with BRAFV600E- and NRAS- mutations.
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| Classification | Small molecule |
| Drug class | rapidly accelerated fibrosarcoma (RAF) kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12 |
Identifiers
| PDB | — |
| CAS-ID | 1446113-23-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3977543 |
| ChEBI ID | — |
| PubChem CID | 89655386 |
| DrugBank | — |
| UNII ID | 31M3WLJ3KG (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
RAF1
RAF1
BRAF
BRAF
Organism
Homo sapiens
Gene name
RAF1
Gene synonyms
RAF
NCBI Gene ID
Protein name
RAF proto-oncogene serine/threonine-protein kinase
Protein synonyms
C-Raf proto-oncogene, serine/threonine kinase, cRaf, Oncogene RAF1, Proto-oncogene c-RAF, raf proto-oncogene serine/threonine protein kinase, Raf-1, v-raf-1 murine leukemia viral oncogene homolog 1, v-raf-1 murine leukemia viral oncogene-like protein 1
Uniprot ID
Mouse ortholog
Raf1 (110157)
RAF proto-oncogene serine/threonine-protein kinase (Q9QUU8)
Variants
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
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