Azactam, Cayston(aztreonam)
Azactam, Aztreonam, Cayston, Emblaveo (aztreonam) is a small molecule pharmaceutical. Aztreonam was first approved as Azactam on 1986-12-31. It is used to treat bacterial infections, cellulitis, endometritis, intraabdominal infections, and pseudomonas infections amongst others in the USA. It has been approved in Europe to treat cystic fibrosis and respiratory tract infections.
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Commercial
Therapeutic Areas
Trade Name
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Azactam, Aztreonam, Cayston (discontinued: Azactam, Aztreonam)
CombinationsEmblaveo
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aztreonam
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AZACTAM | Bristol Myers Squibb | N-050580 RX | 1986-12-31 | 2 products, RLD, RS |
| CAYSTON | Gilead Sciences | N-050814 RX | 2010-02-22 | 1 products, RLD, RS |
Show 2 discontinued
Indications
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| S0073 | Injection, aztreonam, 500 mg |
Clinical
Clinical Trials
69 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | — | — | 1 |
| Communicable diseases | D003141 | — | — | — | 1 | — | — | — | 1 |
| Bacterial infections | D001424 | — | A49 | — | 1 | — | — | — | 1 |
| Gram-negative bacterial infections | D016905 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aztreonam |
| INN | aztreonam |
| Description | Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. It is given by intravenous or intramuscular injection or by inhalation.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c2csc(N)n2)C(=O)N1S(=O)(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 78110-38-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL158 |
| ChEBI ID | 161680 |
| PubChem CID | 5742832 |
| DrugBank | DB00355 |
| UNII ID | G2B4VE5GH8 (ChemIDplus, GSRS) |
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Azactam – Elan Corporation
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Safety
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13,310 adverse events reported
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