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Drug ReportsAztreonam
Azactam, Cayston(aztreonam)
Azactam, Aztreonam, Cayston (aztreonam) is a small molecule pharmaceutical. Aztreonam was first approved as Azactam on 1986-12-31. It is used to treat bacterial infections, cellulitis, endometritis, intraabdominal infections, and pseudomonas infections amongst others in the USA. It has been approved in Europe to treat cystic fibrosis and respiratory tract infections.
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2Y
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EMA approval date
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Study first post date
Last update post date
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Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
respiratory tract diseasesD012140
urogenital diseasesD000091642
hereditary congenital and neonatal diseases and abnormalitiesD009358
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Azactam, Aztreonam, Cayston (discontinued: Azactam, Aztreonam)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aztreonam
Tradename
Company
Number
Date
Products
AZACTAMBristol Myers SquibbN-050580 RX1986-12-31
2 products, RLD, RS
CAYSTONGilead SciencesN-050814 RX2010-02-22
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
azactamNew Drug Application2024-10-25
aztreonamANDA2024-06-03
caystonNew Drug Application2021-12-15
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
respiratory tract infections—D012141J06.9
urinary tract infectionsEFO_0003103D014552N39.0
bacterial infections—D001424A49
intraabdominal infections—D059413—
pseudomonas infectionsEFO_0001076D011552A41.52
endometritisEFO_1001312D004716—
cellulitisEFO_0003035D002481L03.90
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01D: Other beta-lactam antibacterials in atc
— J01DF: Monobactams
— J01DF01: Aztreonam
HCPCS
Code
Description
S0073
Injection, aztreonam, 500 mg
Clinical
Clinical Trials
69 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544—17172228
FibrosisD005355———5911025
Cystic fibrosisD003550EFO_0000390E84—5911025
Pseudomonas infectionsD011552EFO_0001076A41.52—241512
AppendicitisD001064EFO_0007149K37———1—1
PseudomonasD011549—————1—1
Diabetic footD017719EFO_1001459————1—1
UlcerD014456MPATH_579————1—1
Foot ulcerD016523—————1—1
Bronchiolitis obliteransD001989EFO_0007183————1—1
Show 2 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Communicable diseasesD003141——1517—123
Bacterial infectionsD001424—A49245——10
Pseudomonas aeruginosaD011550NCBITaxon_287——12—25
BronchiectasisD001987HP_0002110J47—22——4
Ventilator-associated pneumoniaD053717EFO_1001865J95.851—13——3
PneumoniaD011014EFO_0003106——13——3
Intraabdominal infectionsD059413———12——3
BacteremiaD016470EFO_0003033R78.81——2—13
Bacterial skin diseasesD017192———12——3
Enterobacteriaceae infectionsD004756EFO_1001313———2—13
Show 19 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteomyelitisD010019EFO_0003102M8611———2
Gram-negative bacterial infectionsD016905———2———2
Gastrointestinal microbiomeD000069196———1———1
Nose diseasesD009668———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———2————2
Renal insufficiencyD051437HP_0000083N191————1
Non-small-cell lung carcinomaD002289——1————1
Lung neoplasmsD008175HP_0100526C34.901————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InflammationD007249MP_0001845—————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAztreonam
INNaztreonam
Description
Aztreonam, sold under the brand name Azactam among others, is an antibiotic used primarily to treat infections caused by gram-negative bacteria such as Pseudomonas aeruginosa. This may include bone infections, endometritis, intra abdominal infections, pneumonia, urinary tract infections, and sepsis. It is given by intravenous or intramuscular injection or by inhalation.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)c2csc(N)n2)C(=O)N1S(=O)(=O)O
Identifiers
PDB—
CAS-ID78110-38-0
RxCUI—
ChEMBL IDCHEMBL158
ChEBI ID161680
PubChem CID5742832
DrugBankDB00355
UNII IDG2B4VE5GH8 (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Azactam – Elan Corporation
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Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 16,145 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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12,881 adverse events reported
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