Doptelet(avatrombopag)
Doptelet (avatrombopag) is a small molecule pharmaceutical. Avatrombopag was first approved as Doptelet on 2018-05-21. It is used to treat thrombocytopenia in the USA. It has been approved in Europe to treat thrombocytopenia. It is known to target thrombopoietin receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| hemic and lymphatic diseases | D006425 |
Trade Name
FDA
EMA
Doptelet
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| doptelet | New Drug Application | 2024-07-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| thrombocytopenia | HP_0001873 | D013921 | D69.6 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
AVATROMBOPAG MALEATE, DOPTELET, AKARX INC | |||
| 2026-06-26 | ODE-246 | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Avatrombopag Maleate, Doptelet, Akarx Inc | |||
| 7638536 | 2027-07-28 | DS, DP | |
HCPCS
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Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 4 | 14 | 10 | 6 | 5 | 37 |
| Thrombocytopenic purpura idiopathic | D016553 | EFO_0007160 | D69.3 | 4 | 5 | 6 | 2 | 2 | 18 |
| Aplastic anemia | D000741 | HP_0001915 | D61.9 | — | 4 | 1 | 1 | 3 | 8 |
| Liver diseases | D008107 | HP_0002910 | K70-K77 | — | 3 | 2 | 2 | 1 | 8 |
| Anemia | D000740 | HP_0001903 | D64.9 | — | 4 | 1 | 1 | 2 | 7 |
| Fibrosis | D005355 | — | — | — | — | — | 2 | 1 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | 1 | 2 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | 1 | — | 1 | — | 2 |
| End stage liver disease | D058625 | EFO_1001311 | K72.1 | — | — | — | 2 | — | 2 |
| Liver failure | D017093 | HP_0001399 | K72.9 | — | — | — | 2 | — | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Thrombocytopenic purpura | D011696 | — | — | 4 | 2 | 1 | — | — | 7 |
| Purpura | D011693 | HP_0000979 | D69.2 | 4 | 2 | 1 | — | — | 7 |
| Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 2 | — | — | 1 | 3 |
| Blood platelet disorders | D001791 | — | — | — | 2 | — | — | — | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | 1 | 2 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | — | 1 | — | — | 1 | 2 |
| Lymphoma | D008223 | — | C85.9 | — | 1 | — | — | — | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | 1 | — | — | — | 1 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | 1 | — | — | — | 1 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 1 | — | — | — | 1 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | — | 1 | — | — | — | 1 |
| Digestive system neoplasms | D004067 | — | — | — | 1 | — | — | — | 1 |
Show 2 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Umbilical hernia | D006554 | — | Q79.2 | — | — | — | — | 1 | 1 |
| Hernia | D006547 | HP_0100790 | K40-K46 | — | — | — | — | 1 | 1 |
| Pancytopenia | D010198 | HP_0001876 | D61.81 | — | — | — | — | 1 | 1 |
| Bone marrow failure disorders | D000080983 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Avatrombopag |
| INN | avatrombopag |
| Description | Avatrombopag, sold under the brand name Doptelet, is a medication that used for certain conditions that lead to thrombocytopenia (low platelets) such as thrombocytopenia associated with chronic liver disease in adults who are to undergo a planned medical or dental procedure. It was approved for medical use in the United States in May 2018, the European Union in June 2019, and Australia in January 2023.
|
| Classification | Small molecule |
| Drug class | thrombopoetin agonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | O=C(Nc1nc(-c2cc(Cl)cs2)c(N2CCN(C3CCCCC3)CC2)s1)c1cnc(N2CCC(C(=O)O)CC2)c(Cl)c1 |
Identifiers
| PDB | — |
| CAS-ID | 570406-98-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2103883 |
| ChEBI ID | — |
| PubChem CID | 9852519 |
| DrugBank | DB11995 |
| UNII ID | 3H8GSZ4SQL (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
MPL
MPL
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 462 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,484 adverse events reported
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