Tavneos(avacopan)
Tavneos (avacopan) is a small molecule pharmaceutical. Avacopan was first approved as Tavneos on 2021-10-07. It is used to treat anti-neutrophil cytoplasmic antibody-associated vasculitis in the USA. It has been approved in Europe to treat microscopic polyangiitis. It is known to target C5a anaphylatoxin chemotactic receptor 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Tavneos
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Avacopan
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TAVNEOS | Chemocentryx | N-214487 RX | 2021-10-07 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tavneos | New Drug Application | 2024-12-10 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| anti-neutrophil cytoplasmic antibody-associated vasculitis | — | D056648 | I77.82 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
AVACOPAN, TAVNEOS, CHEMOCENTRYX | |||
| 2028-10-07 | ODE-377 | ||
| 2026-10-07 | NCE | ||
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasculitis | D014657 | EFO_0006803 | M31 | 5 | 2 | 2 | 2 | 2 | 13 |
| Anti-neutrophil cytoplasmic antibody-associated vasculitis | D056648 | — | I77.82 | 4 | 1 | 1 | 2 | 2 | 10 |
Indications Phases 3
No data
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 2 | — | — | — | 3 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | 2 | — | — | — | 2 |
| Glomerulonephritis | D005921 | — | N05 | — | 1 | — | — | — | 1 |
| Hidradenitis suppurativa | D017497 | — | L73.2 | — | 1 | — | — | — | 1 |
| Hidradenitis | D016575 | — | — | — | 1 | — | — | — | 1 |
| Hemolytic-uremic syndrome | D006463 | — | D59.3 | — | 1 | — | — | — | 1 |
| Hemolysis | D006461 | — | — | — | 1 | — | — | — | 1 |
| Syndrome | D013577 | — | — | — | 1 | — | — | — | 1 |
| Atypical hemolytic uremic syndrome | D065766 | — | — | — | 1 | — | — | — | 1 |
| Azotemia | D053099 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Electrocardiography | D004562 | EFO_0004327 | — | 1 | — | — | — | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | 1 | — | — | — | — | 1 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Granulomatosis with polyangiitis | D014890 | EFO_0005297 | M31.3 | — | — | — | — | 1 | 1 |
| Microscopic polyangiitis | D055953 | EFO_1000784 | M31.7 | — | — | — | — | 1 | 1 |
| Systemic vasculitis | D056647 | — | — | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Avacopan |
| INN | avacopan |
| Description | Avacopan, sold under the brand name Tavneos, is a medication used to treat anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Avacopan is a complement 5a receptor antagonist and a cytochrome P450 3A4 inhibitor.
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| Classification | Small molecule |
| Drug class | complement receptor antagonists/complement inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(NC(=O)[C@H]2CCCN(C(=O)c3c(C)cccc3F)[C@H]2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 1346623-17-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3989871 |
| ChEBI ID | — |
| PubChem CID | 49841217 |
| DrugBank | DB15011 |
| UNII ID | O880NM097T (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
C5AR1
C5AR1
Organism
Homo sapiens
Gene name
C5AR1
Gene synonyms
C5AR, C5R1
NCBI Gene ID
Protein name
C5a anaphylatoxin chemotactic receptor 1
Protein synonyms
C5a anaphylatoxin chemotactic receptor, C5a anaphylatoxin receptor, C5a ligand, C5a-R, C5aR, CD88, complement component 5a receptor 1
Uniprot ID
Mouse ortholog
C5ar1 (12273)
C5a anaphylatoxin chemotactic receptor 1 (Q3TZ86)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,414 adverse events reported
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