Atrasentan
Atrasentan is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against endothelin-1 receptor. In addition, it is known to target endothelin receptor type B.
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Commercial
Therapeutic Areas
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Trade Name
FDA
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vanrafia | New Drug Application | 2025-04-02 |
Indications
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Agency Specific
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ATC Codes
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Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | — | 3 | 4 | — | — | 6 |
| Adenocarcinoma | D000230 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atrasentan |
| INN | atrasentan |
| Description | Atrasentan is a member of pyrrolidines. |
| Classification | Small molecule |
| Drug class | endothelin receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 173937-91-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL9194 |
| ChEBI ID | — |
| PubChem CID | 159594 |
| DrugBank | DB06199 |
| UNII ID | V6D7VK2215 (ChemIDplus, GSRS) |
Target
Agency Approved
EDNRA
EDNRA
Organism
Homo sapiens
Gene name
EDNRA
Gene synonyms
ETA, ETRA
NCBI Gene ID
Protein name
endothelin-1 receptor
Protein synonyms
endothelin receptor subtype A, Endothelin receptor type A, endothelin-1-specific receptor, ET-A, ETA-R, G protein-coupled receptor, hET-AR
Uniprot ID
Mouse ortholog
Ednra (13617)
endothelin-1 receptor (Q91VV2)
Alternate
EDNRB
EDNRB
Variants
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 1,434 documents
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Safety
Black-box Warning
Black-box warning for: Vanrafia
Adverse Events
Top Adverse Reactions
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18 adverse events reported
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