Atrasentan
Vanrafia (atrasentan) is a small molecule pharmaceutical. Atrasentan was first approved as Vanrafia on 2025-04-02. The pharmaceutical is active against endothelin-1 receptor. In addition, it is known to target endothelin receptor type B.
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FDA approval date
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
Vanrafia
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| vanrafia | New Drug Application | 2025-06-06 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| proteinuria | — | D011507 | R80 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
21 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 7 | 2 | — | 1 | 10 |
| Prostatic neoplasms | D011471 | — | C61 | — | 3 | 5 | — | — | 7 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | — | 5 | 1 | — | — | 6 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | 2 | 1 | — | 1 | 4 |
| Adenocarcinoma | D000230 | — | — | — | 2 | 1 | — | — | 2 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | — | 4 | — | — | — | 4 |
| Albuminuria | D000419 | EFO_0004285 | R80.9 | — | 3 | — | — | — | 3 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | — | — | — | 1 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Fallopian tube neoplasms | D005185 | — | — | — | 1 | — | — | — | 1 |
| Papillary adenocarcinoma | D000231 | — | — | — | 1 | — | — | — | 1 |
| Focal segmental glomerulosclerosis | D005923 | EFO_0004236 | — | — | 1 | — | — | — | 1 |
| Hereditary nephritis | D009394 | EFO_0004128 | Q87.81 | — | 1 | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Central nervous system neoplasms | D016543 | — | — | 1 | — | — | — | — | 1 |
| Nervous system neoplasms | D009423 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atrasentan |
| INN | atrasentan |
| Description | Atrasentan is a member of pyrrolidines. |
| Classification | Small molecule |
| Drug class | endothelin receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCN(CCCC)C(=O)CN1C[C@H](c2ccc3c(c2)OCO3)[C@@H](C(=O)O)[C@@H]1c1ccc(OC)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 173937-91-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL9194 |
| ChEBI ID | — |
| PubChem CID | 159594 |
| DrugBank | DB06199 |
| UNII ID | V6D7VK2215 (ChemIDplus, GSRS) |
Target
Agency Approved
EDNRA
EDNRA
Organism
Homo sapiens
Gene name
EDNRA
Gene synonyms
ETA, ETRA
NCBI Gene ID
Protein name
endothelin-1 receptor
Protein synonyms
endothelin receptor subtype A, Endothelin receptor type A, endothelin-1-specific receptor, ET-A, ETA-R, G protein-coupled receptor, hET-AR
Uniprot ID
Mouse ortholog
Ednra (13617)
endothelin-1 receptor (Q91VV2)
Alternate
EDNRB
EDNRB
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,507 documents
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Safety
Black-box Warning
Black-box warning for: Vanrafia
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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