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AboutPricing
Drug ReportsAtovaquone
Atovaquone
Atovaquone, Malarone, Mepron (atovaquone) is a small molecule pharmaceutical. Atovaquone was first approved as Mepron on 1992-11-25. It is used to treat cerebral toxoplasmosis, malaria, and pneumocystis pneumonia in the USA. It is known to target Cytochrome b.
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FDA approval date
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Study first post date
Last update post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
nervous system diseasesD009422
Trade Name
FDA
EMA
Atovaquone, Mepron (discontinued: Atovaquone, Mepron)
Combinations
Atovaquone proguanil, Malarone
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atovaquone
+
Proguanil hydrochloride
Tradename
Company
Number
Date
Products
MALARONEGSKN-021078 RX2000-07-14
1 products, RLD, RS
MALARONE PEDIATRICGSKN-021078 RX2000-07-14
1 products, RLD
Atovaquone
Tradename
Company
Number
Date
Products
MEPRONGSKN-020500 RX1995-02-08
1 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
atovaquoneANDA2025-11-07
atovaquone and proguanil hclNDA authorized generic2023-10-23
atovaquone and proguanil hydrochlorideANDA2024-07-01
atovaquone and proguanil hydrochloride atovaquone and proguanil hydrochloride pediatricANDA2019-12-31
atovaquone oral suspensionANDA2024-02-15
malaroneNew Drug Application2023-11-14
mepronNew Drug Application2023-07-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
malariaEFO_0001068D008288B54
cerebral toxoplasmosisEFO_0007200D016781B58.2
pneumocystis pneumoniaEFO_0007448D011020B59
falciparum malariaEFO_0007444D016778B50
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
P: Antiparasitic products, insecticides and repellents
— P01: Antiprotozoals
— P01A: Agents against amoebiasis and other protozoal diseases
— P01AX: Other agents against amoebiasis and other protozoal diseases in atc
— P01AX06: Atovaquone
— P01B: Antimalarials
— P01BB: Biguanide antimalarials
— P01BB51: Proguanil and atovaquone
HCPCS
No data
Clinical
Clinical Trials
57 clinical trials
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
MalariaD008288EFO_0001068B541————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAtovaquone
INNatovaquone
Description
Atovaquone is a naphthoquinone compound having a 4-(4-chlorophenyl)cyclohexyl group at the 2-position and a hydroxy substituent at the 3-position. It has a role as an antimalarial, an antifungal agent, an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor and an EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor. It is a member of monochlorobenzenes and a hydroxy-1,4-naphthoquinone.
Classification
Small molecule
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
O=C1C(O)=C([C@H]2CC[C@H](c3ccc(Cl)cc3)CC2)C(=O)c2ccccc21
Identifiers
PDB—
CAS-ID95233-18-4
RxCUI—
ChEMBL IDCHEMBL1450
ChEBI ID575568
PubChem CID74989
DrugBankDB01117
UNII IDY883P1Z2LT (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MT-CYB
MT-CYB
Organism
Plasmodium falciparum
Gene name
MT-CYB
Gene synonyms
COB, CYTB, MTCYB
NCBI Gene ID
—
Protein name
Cytochrome b
Protein synonyms
Complex III subunit 3, Complex III subunit III, Cytochrome b-c1 complex subunit 3, Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Uniprot ID
Q02768
Mouse ortholog
—
—
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Atovaquone – Amneal Pharmaceuticals
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Estimated US medical usage
Atovaquone
+
Proguanil
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,826 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,846 adverse events reported
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