PharmaKB logo
Company Reports
Company Reports
Drug Reports
Drug Reports
Disease Reports
Disease Reports
AboutPricing
Drug ReportsAtorvastatin
Atorvastatin
Atorvaliq, Atorvastatin, Caduet, Lipitor, Lypqozet (atorvastatin) is a small molecule pharmaceutical. Atorvastatin was first approved as Lipitor on 1996-12-17. It is used to treat coronary artery disease, hypercholesterolemia, hyperlipoproteinemias, and hypertriglyceridemia in the USA. The pharmaceutical is active against 3-hydroxy-3-methylglutaryl-Coenzyme A reductase.
Download report
Favorite
Top Prescription Drugs
Top 200 Pharmaceuticals by Retail Sales
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Plot placeholder
Mock data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
nutritional and metabolic diseasesD009750
Trade Name
FDA
EMA
Atorvaliq, Atorvastatin, Lipitor (discontinued: Atorvastatin)
Combinations
Amlodipine besylate atorvastatin, Caduet, Lypqozet (discontinued: Amlodipine besylate atorvastatin, Liptruzet)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atorvastatin calcium
+
Ezetimibe
Tradename
Company
Number
Date
Products
LIPTRUZETOrganonN-200153 DISCN2013-05-03
4 products, RLD
Hide discontinued
Atorvastatin calcium
Tradename
Company
Number
Date
Products
ATORVALIQCMP PharmaN-213260 RX2023-02-01
1 products, RLD, RS
LIPITORUpjohnN-020702 RX1996-12-17
4 products, RLD
Amlodipine besylate
+
Atorvastatin calcium
Tradename
Company
Number
Date
Products
CADUETPharmacia & UpjohnN-021540 RX2004-01-30
11 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
amlodipine and atorvastatinANDA2025-05-23
amlodipine besylate and atorvastatin calciumANDA2021-02-16
atorvastatin calciumANDA2025-05-28
caduetNew Drug Application2025-03-03
lipitorNew Drug Application2024-04-15
lypqozetANDA2024-01-24
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Atorvastatin Calcium, Atorvaliq, Cmp Dev Llc
113695672037-06-07DP
116541062037-06-07DPU-3612, U-3613
ATC Codes
C: Cardiovascular system drugs
C10: Lipid modifying agents
C10A: Lipid modifying agents, plain
C10AA: Hmg coa reductase inhibitors, plain lipid modifying drugs
C10AA05: Atorvastatin
C10B: Lipid modifying agents, combinations
C10BA: Combinations of various lipid modifying agents
C10BA05: Atorvastatin and ezetimibe
C10BA08: Atorvastatin and omega-3 fatty acids
C10BX: Lipid modifying agents in combination with other drugs
C10BX03: Atorvastatin and amlodipine
C10BX06: Atorvastatin, acetylsalicylic acid and ramipril
C10BX08: Atorvastatin and acetylsalicylic acid
C10BX11: Atorvastatin, amlodipine and perindopril
C10BX12: Atorvastatin, acetylsalicylic acid and perindopril
C10BX15: Atorvastatin and perindopril
C10BX18: Atorvastatin, amlodipine and ramipril
HCPCS
No data
Clinical
Clinical Trials
1119 clinical trials
View more details
Plot placeholder
Mock data
Subscribe for the real data
Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypercholesterolemiaD006937309140
Coronary diseaseD00332774112
Coronary artery diseaseD003324I25.165112
Myocardial ischemiaD017202EFO_1001375I20-I2564111
Heart diseasesD006331EFO_0003777I51.96219
AtherosclerosisD050197EFO_0003914I25.1246
Cardiovascular diseasesD002318EFO_0000319I98213
Metabolic syndromeD024821EFO_0000195E88.810213
ArteriosclerosisD001161EFO_0009086I7011
Indications Phases 3
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HyperlipidemiasD006949EFO_0003774E78.511
HyperlipoproteinemiasD00695111
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
Drug common nameAtorvastatin
INNatorvastatin
Description
Atorvastatin is a dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. It has a role as an environmental contaminant and a xenobiotic. It is an aromatic amide, a member of monofluorobenzenes, a statin (synthetic), a dihydroxy monocarboxylic acid and a member of pyrroles. It is functionally related to a heptanoic acid. It is a conjugate acid of an atorvastatin(1-).
Classification
Small molecule
Drug classenzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O
Identifiers
PDB
CAS-ID134523-00-5
RxCUI
ChEMBL IDCHEMBL1487
ChEBI ID39548
PubChem CID60823
DrugBankDB01076
UNII IDA0JWA85V8F (ChemIDplus, GSRS)
Target
Agency Approved
HMGCR
HMGCR
Organism
Homo sapiens
Gene name
HMGCR
Gene synonyms
NCBI Gene ID
Protein name
3-hydroxy-3-methylglutaryl-Coenzyme A reductase
Protein synonyms
3-hydroxy-3-methylglutaryl CoA reductase (NADPH), HMG-CoA reductase, hydroxymethylglutaryl-CoA reductase
Uniprot ID
Mouse ortholog
Hmgcr (15357)
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Q5U4I2)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
£
Caduet Pfizer
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Liptruzet Organon
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Lipitor Viatris
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Lipitor Pfizer
Plot placeholder
Mock data
Subscribe for the real data
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Estimated US medical usage
Atorvastatin
+
Amlodipine
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Atorvastatin
Total medical expenditures per year (USD, in millions)
Plot placeholder
Mock data
Subscribe for the real data
Number of persons purchased
Plot placeholder
Mock data
Subscribe for the real data
Number of purchases
Plot placeholder
Mock data
Subscribe for the real data
Refill frequency
Plot placeholder
Mock data
Subscribe for the real data
Price per prescription (USD)
Plot placeholder
Mock data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Plot placeholder
Mock data
Subscribe for the real data
Additional graphs summarizing 50,629 documents
View more details
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Plot placeholder
Mock data
Subscribe for the real data
134,796 adverse events reported
View more details
© 2020-2025 Collaborative Drug Discovery Inc. (CDD) | Terms of Use