Therapeutic Area | MeSH |
---|---|
cardiovascular diseases | D002318 |
nutritional and metabolic diseases | D009750 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CADUET | Pharmacia & Upjohn | N-021540 RX | 2004-01-30 | 11 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
ATORVALIQ | CMP Pharma | N-213260 RX | 2023-02-01 | 1 products, RLD, RS |
LIPITOR | Upjohn | N-020702 RX | 1996-12-17 | 4 products, RLD |
Brand Name | Status | Last Update |
---|---|---|
amlodipine and atorvastatin | NDA authorized generic | 2023-10-31 |
amlodipine besylate and atorvastatin calcium | NDA authorized generic | 2023-10-31 |
atorvastatin calcium | ANDA | 2024-02-09 |
caduet | New Drug Application | 2023-08-30 |
lipitor | New Drug Application | 2023-02-15 |
lypqozet | ANDA | 2024-01-24 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypercholesterolemia | D006937 | HP_0003124 | — | 9 | 23 | 78 | 42 | 17 | 169 |
Dyslipidemias | D050171 | HP_0003119 | — | 8 | 15 | 27 | 31 | 10 | 90 |
Coronary artery disease | D003324 | — | I25.1 | — | 3 | 15 | 34 | 14 | 65 |
Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 11 | 12 | 27 | 8 | 5 | 61 |
Healthy volunteers/patients | — | — | — | 48 | 1 | — | 6 | 3 | 58 |
Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 8 | 10 | 18 | 12 | 48 |
Hypertension | D006973 | EFO_0000537 | I10 | 6 | 4 | 7 | 20 | 7 | 43 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 2 | 2 | 10 | 17 | 8 | 38 |
Atherosclerosis | D050197 | EFO_0003914 | I25.1 | 1 | 2 | 10 | 16 | 10 | 38 |
Acute coronary syndrome | D054058 | EFO_0005672 | — | 2 | 1 | 6 | 13 | 7 | 29 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 9 | 1 | — | — | 11 |
Covid-19 | D000086382 | — | U07.1 | 1 | 2 | 6 | — | 2 | 10 |
Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | 1 | 7 | — | 2 | 10 |
Prostatic neoplasms | D011471 | — | C61 | 1 | 4 | 2 | — | 2 | 9 |
Chronic periodontitis | D055113 | EFO_0006343 | K05.3 | — | 8 | 7 | — | — | 8 |
Neoplasms | D009369 | — | C80 | 2 | 3 | 2 | — | — | 6 |
Hiv | D006678 | — | O98.7 | 1 | 2 | 1 | — | 1 | 5 |
Subdural hematoma chronic | D020200 | — | — | — | 2 | 1 | — | 1 | 4 |
Myelodysplastic syndromes | D009190 | — | D46 | 1 | 2 | 1 | — | — | 4 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 2 | 1 | — | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | 2 | — | — | 2 | 5 |
Non-alcoholic fatty liver disease | D065626 | EFO_0003095 | K75.81 | 1 | 2 | — | — | 2 | 5 |
Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 3 | 2 | — | — | — | 4 |
Percutaneous coronary intervention | D062645 | — | — | 1 | 1 | — | — | 2 | 3 |
Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | 1 | — | — | 2 | 3 |
Cardiotoxicity | D066126 | EFO_1001482 | — | — | 3 | — | — | — | 3 |
Mucocutaneous lymph node syndrome | D009080 | EFO_0004246 | M30.3 | 2 | 2 | — | — | — | 3 |
Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | 2 | 3 |
Balloon angioplasty coronary | D015906 | EFO_0003951 | — | — | 2 | — | — | 1 | 3 |
Pathologic constriction | D003251 | — | — | 1 | 1 | — | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Drug interactions | D004347 | — | — | 3 | — | — | — | 1 | 4 |
Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | — | — | — | 1 | 2 |
Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
Infections | D007239 | EFO_0000544 | — | 1 | — | — | — | 1 | 2 |
Hereditary nonpolyposis colorectal neoplasms | D003123 | EFO_0007354 | — | 1 | — | — | — | — | 1 |
Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | 1 | — | — | — | — | 1 |
Lipodystrophy | D008060 | HP_0009125 | E88.1 | 1 | — | — | — | — | 1 |
Hiv seronegativity | D018023 | — | — | 1 | — | — | — | — | 1 |
Hemorrhage | D006470 | MP_0001914 | R58 | 1 | — | — | — | — | 1 |
Epilepsy | D004827 | EFO_0000474 | G40.9 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Medication adherence | D055118 | EFO_0006344 | — | — | — | — | — | 2 | 2 |
Delirium | D003693 | — | R41.0 | — | — | — | — | 2 | 2 |
Asymptomatic diseases | D058070 | — | — | — | — | — | — | 2 | 2 |
Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 2 | 2 |
Aneurysm | D000783 | HP_0002617 | I72.9 | — | — | — | — | 2 | 2 |
Diastolic heart failure | D054144 | EFO_1000899 | I50.30 | — | — | — | — | 2 | 2 |
Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | — | — | — | 1 | 1 |
Coronary occlusion | D054059 | — | I21 | — | — | — | — | 1 | 1 |
Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 1 | 1 |
Intracranial embolism | D020766 | EFO_1000991 | I66 | — | — | — | — | 1 | 1 |
Drug common name | Atorvastatin |
INN | atorvastatin |
Description | Atorvastatin is a dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. It has a role as an environmental contaminant and a xenobiotic. It is an aromatic amide, a member of monofluorobenzenes, a statin (synthetic), a dihydroxy monocarboxylic acid and a member of pyrroles. It is functionally related to a heptanoic acid. It is a conjugate acid of an atorvastatin(1-). |
Classification | Small molecule |
Drug class | enzyme inhibitors: antihyperlipidemics (HMG-CoA inhibitors) |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CC(C)c1c(C(=O)Nc2ccccc2)c(-c2ccccc2)c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)O |
PDB | — |
CAS-ID | 134523-00-5 |
RxCUI | — |
ChEMBL ID | CHEMBL1487 |
ChEBI ID | 39548 |
PubChem CID | 60823 |
DrugBank | DB01076 |
UNII ID | A0JWA85V8F (ChemIDplus, GSRS) |