Atomoxetine
Atomoxetine, Strattera (atomoxetine) is a small molecule pharmaceutical. Atomoxetine was first approved as Strattera on 2002-11-26. It is used to treat attention deficit disorder with hyperactivity in the USA. The pharmaceutical is active against sodium-dependent noradrenaline transporter. In addition, it is known to target sodium-dependent serotonin transporter and sodium-dependent dopamine transporter.
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Events
FDA approval date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| mental disorders | D001523 |
Trade Name
FDA
EMA
Atomoxetine (discontinued: Strattera)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atomoxetine | ANDA | 2025-10-02 |
| atomoxetine hydrochloride | ANDA | 2025-10-02 |
| strattera | New Drug Application | 2024-02-28 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| attention deficit disorder with hyperactivity | EFO_0003888 | D001289 | F90 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
No data
Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 2 | 4 | 22 | 25 | 2 | 54 |
| Hyperkinesis | D006948 | — | — | 1 | 4 | 21 | 18 | 1 | 44 |
| Dyslexia | D004410 | EFO_0005424 | F81.0 | — | — | — | 4 | — | 4 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 1 | 1 | — | 2 | — | 3 |
| Attention deficit and disruptive behavior disorders | D019958 | — | F91.3 | — | — | 2 | 1 | — | 3 |
| Oppositional defiant disorder | D000096865 | — | — | — | — | 2 | 1 | — | 3 |
| Anxiety disorders | D001008 | EFO_0006788 | F41.1 | — | 1 | 1 | 1 | — | 2 |
| Social phobia | D000072861 | EFO_1001917 | F40.1 | — | 1 | 1 | 1 | — | 2 |
| Depression | D003863 | — | F33.9 | — | — | — | 1 | — | 1 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Alzheimer disease | D000544 | EFO_0000249 | F03 | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Substance-related disorders | D019966 | EFO_0003890 | F13 | — | 1 | — | — | 1 | 2 |
| Cocaine-related disorders | D019970 | — | F14 | — | 1 | — | — | — | 1 |
| Huntington disease | D006816 | Orphanet_399 | G10 | — | 1 | — | — | — | 1 |
| Chorea | D002819 | EFO_0004152 | G25.5 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Fetal alcohol spectrum disorders | D063647 | — | Q86.0 | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | — | 1 | 1 |
| Transient ischemic attack | D002546 | EFO_0003764 | G45.9 | — | — | — | — | 1 | 1 |
| Cognitive dysfunction | D060825 | — | G31.84 | — | — | — | — | 1 | 1 |
| Neurocognitive disorders | D019965 | — | F09 | — | — | — | — | 1 | 1 |
| Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 1 | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atomoxetine |
| INN | atomoxetine |
| Description | Atomoxetine is a secondary amino compound having methyl and 3-(2-methylphenoxy)-3-phenylpropan-1-yl substituents. It has a role as an adrenergic uptake inhibitor, an antidepressant, a xenobiotic and an environmental contaminant. It is an aromatic ether, a secondary amino compound and a member of toluenes. |
| Classification | Small molecule |
| Drug class | antidepressants (fluoxetine type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CNCC[C@@H](Oc1ccccc1C)c1ccccc1 |
Identifiers
| PDB | — |
| CAS-ID | 83015-26-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL641 |
| ChEBI ID | 127342 |
| PubChem CID | 54841 |
| DrugBank | DB00289 |
| UNII ID | ASW034S0B8 (ChemIDplus, GSRS) |
Target
Agency Approved
SLC6A2
SLC6A2
Organism
Homo sapiens
Gene name
SLC6A2
Gene synonyms
NAT1, NET1, SLC6A5
NCBI Gene ID
Protein name
sodium-dependent noradrenaline transporter
Protein synonyms
NET, neurotransmitter transporter, Norepinephrine transporter, solute carrier family 6 (neurotransmitter transporter), member 2, solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2, Solute carrier family 6 member 2, solute carrier family 6 member 5
Uniprot ID
Mouse ortholog
Slc6a2 (20538)
sodium-dependent noradrenaline transporter (Q6QU62)
Alternate
SLC6A4
SLC6A4
SLC6A3
SLC6A3
Organism
Homo sapiens
Gene name
SLC6A4
Gene synonyms
HTT, SERT
NCBI Gene ID
Protein name
sodium-dependent serotonin transporter
Protein synonyms
5-hydroxytryptamine (serotonin) transporter, 5HT transporter, 5HTT, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4, Solute carrier family 6 member 4
Uniprot ID
Mouse ortholog
Slc6a4 (15567)
sodium-dependent serotonin transporter (Q60857)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Strattera – Eli Lilly
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Tabular view
Estimated US medical usage
Atomoxetine
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 7,708 documents
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Safety
Black-box Warning
Black-box warning for: Atomoxetine, Atomoxetine hydrochloride, Strattera
Adverse Events
Top Adverse Reactions
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23,809 adverse events reported
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