Aticaprant
Aticaprant is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | 1 | 5 | — | — | 6 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | 5 | — | — | 6 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | 1 | 5 | — | — | 6 |
| Anhedonia | D059445 | — | R45.84 | — | — | 4 | — | — | 4 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Smoking | D012907 | EFO_0004318 | — | — | 2 | — | — | — | 2 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 3 | — | — | — | — | 3 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aticaprant |
| INN | aticaprant |
| Description | Aticaprant, also known by its developmental codes JNJ-67953964, CERC-501, and LY-2456302, is a κ-opioid receptor (KOR) antagonist which is under development for the treatment of major depressive disorder. A regulatory application for approval of the medication is expected to be submitted by 2025. Aticaprant is taken by mouth.
|
| Classification | Small molecule |
| Drug class | kappa opiod receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cc(C)cc([C@@H]2CCCN2Cc2ccc(Oc3ccc(C(N)=O)cc3F)cc2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1174130-61-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1921847 |
| ChEBI ID | — |
| PubChem CID | 44129648 |
| DrugBank | DB12341 |
| UNII ID | DE4G8X55F5 (ChemIDplus, GSRS) |
Target
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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