Tecentriq(atezolizumab)
Tecentriq (atezolizumab) is an antibody pharmaceutical. Atezolizumab was first approved as Tecentriq on 2016-05-18. It is used to treat non-small-cell lung carcinoma and urinary bladder neoplasms in the USA. It has been approved in Europe to treat breast neoplasms, non-small-cell lung carcinoma, small cell lung carcinoma, transitional cell carcinoma, and urologic neoplasms. The pharmaceutical is active against programmed cell death 1 ligand 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Tecentriq
CombinationsTecentriq hybreza
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tecentriq | Biologic Licensing Application | 2024-11-20 |
| tecentriq hybreza | Biologic Licensing Application | 2024-09-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-small-cell lung carcinoma | — | D002289 | — |
| hepatocellular carcinoma | — | D006528 | C22.0 |
| urinary bladder neoplasms | — | D001749 | C67 |
| melanoma | — | D008545 | — |
| small cell lung carcinoma | — | D055752 | — |
| alveolar soft part sarcoma | — | D018234 | — |
| extravasation of diagnostic and therapeutic materials | — | D005119 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
atezolizumab, Tecentriq, Genentech, Inc. | |||
| 2029-12-09 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9022 | Injection, atezolizumab, 10 mg |
Clinical
Clinical Trials
1520 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 6 | 18 | 21 | 2 | 6 | 49 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 6 | 18 | 17 | 1 | 3 | 40 |
| Neoplasms | D009369 | — | C80 | 15 | 21 | 7 | 1 | 1 | 38 |
| Adenocarcinoma | D000230 | — | — | 3 | 6 | 2 | 1 | — | 10 |
| Adenocarcinoma of lung | D000077192 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 7 | 19 | 16 | — | 6 | 43 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 12 | 20 | 12 | — | 2 | 41 |
| Triple negative breast neoplasms | D064726 | — | — | 7 | 11 | 8 | — | 1 | 26 |
| Small cell lung carcinoma | D055752 | — | — | 4 | 6 | 5 | — | 4 | 17 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 1 | 5 | 8 | — | 3 | 16 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 2 | 6 | 6 | — | 3 | 15 |
| Colorectal neoplasms | D015179 | — | — | 5 | 9 | 3 | — | — | 15 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | 8 | 3 | — | — | 11 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 3 | 4 | — | — | 10 |
| Transitional cell carcinoma | D002295 | — | — | 2 | 4 | 2 | — | 2 | 9 |
Show 22 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 9 | 8 | — | — | 1 | 12 |
| B-cell lymphoma | D016393 | — | — | 4 | 4 | — | — | 1 | 6 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 1 | 4 | — | — | — | 5 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 5 | 3 | — | — | — | 5 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 3 | 3 | — | — | 1 | 5 |
| Follicular lymphoma | D008224 | — | C82 | 5 | 4 | — | — | — | 5 |
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | — | 4 | — | — | — | 4 |
| Leukemia | D007938 | — | C95 | 3 | 1 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 3 | 1 | — | — | — | 3 |
| Sarcoma | D012509 | — | — | — | 3 | — | — | — | 3 |
Show 42 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | — | — | — | — | 2 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Syndrome | D013577 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atezolizumab |
| INN | atezolizumab |
| Description | Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), small cell lung cancer (SCLC), hepatocellular carcinoma, and alveolar soft part sarcoma. It is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1).
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5XXY:H|heavy chain of atezolizumab fab
EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTMDPGGSHHHHHHHH
>5XXY:L|light chain of atezolizumab fab
DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 5X8L, 5XXY |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707227 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11595 |
| UNII ID | 52CMI0WC3Y (ChemIDplus, GSRS) |
Target
Agency Approved
CD274
CD274
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Tecentriq – Roche
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 33,839 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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30,094 adverse events reported
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