Tecentriq(atezolizumab)
Tecentriq (atezolizumab) is an antibody pharmaceutical. Atezolizumab was first approved as Tecentriq on 2016-05-18. It is used to treat alveolar soft part sarcoma, hepatocellular carcinoma, melanoma, non-small-cell lung carcinoma, and small cell lung carcinoma amongst others in the USA. It has been approved in Europe to treat breast neoplasms, non-small-cell lung carcinoma, small cell lung carcinoma, transitional cell carcinoma, and urologic neoplasms. The pharmaceutical is active against programmed cell death 1 ligand 1.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Tecentriq
CombinationsTecentriq hybreza
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tecentriq | Biologic Licensing Application | 2024-11-20 |
| tecentriq hybreza | Biologic Licensing Application | 2024-09-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-small-cell lung carcinoma | — | D002289 | — |
| hepatocellular carcinoma | — | D006528 | C22.0 |
| urinary bladder neoplasms | — | D001749 | C67 |
| melanoma | — | D008545 | — |
| small cell lung carcinoma | — | D055752 | — |
| alveolar soft part sarcoma | — | D018234 | — |
| extravasation of diagnostic and therapeutic materials | — | D005119 | — |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
atezolizumab, Tecentriq, Genentech, Inc. | |||
| 2029-12-09 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9022 | Injection, atezolizumab, 10 mg |
Clinical
Clinical Trials
1577 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Carcinoma | D002277 | — | C80.0 | 8 | 18 | — | 1 | 1 | 28 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 2 | 6 | — | 1 | — | 9 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 1 | 6 | 1 | 1 | — | 9 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 3 | 8 | 1 | — | — | 10 |
| Triple negative breast neoplasms | D064726 | — | — | 2 | 4 | 1 | — | — | 7 |
| Adenocarcinoma | D000230 | — | — | 2 | 5 | 1 | — | — | 7 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 3 | 2 | 1 | — | — | 5 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 3 | 1 | 1 | — | — | 4 |
| Colonic neoplasms | D003110 | — | C18 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 13 | 20 | — | — | — | 30 |
| Lung neoplasms | D008175 | — | C34.90 | 7 | 19 | — | — | — | 23 |
| Neoplasms | D009369 | — | C80 | 15 | 7 | — | — | — | 21 |
| Prostatic neoplasms | D011471 | — | C61 | 4 | 5 | — | — | — | 8 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | 3 | 5 | — | — | — | 8 |
| Melanoma | D008545 | — | — | 6 | 2 | — | — | — | 8 |
| Squamous cell carcinoma | D002294 | — | — | 2 | 5 | — | — | — | 7 |
| Urologic neoplasms | D014571 | — | C64-C68 | 3 | 4 | — | — | 1 | 7 |
| Transitional cell carcinoma | D002295 | — | — | 2 | 5 | — | — | 1 | 7 |
| Colorectal neoplasms | D015179 | — | — | 3 | 3 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 2 | — | — | — | — | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
| Urogenital neoplasms | D014565 | EFO_0003863 | D07 | 1 | — | — | — | — | 1 |
| Urologic diseases | D014570 | — | N39.9 | 1 | — | — | — | — | 1 |
| Neoplasms by histologic type | D009370 | — | — | 1 | — | — | — | — | 1 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | 1 | — | — | — | — | 1 |
| Esophageal neoplasms | D004938 | — | C15 | 1 | — | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
| Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | 1 | — | — | — | — | 1 |
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atezolizumab |
| INN | atezolizumab |
| Description | Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), small cell lung cancer (SCLC), hepatocellular carcinoma, and alveolar soft part sarcoma. It is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1).
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5XXY:H|heavy chain of atezolizumab fab
EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTMDPGGSHHHHHHHH
>5XXY:L|light chain of atezolizumab fab
DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 5X8L, 5XXY |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707227 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11595 |
| UNII ID | 52CMI0WC3Y (ChemIDplus, GSRS) |
Target
Agency Approved
CD274
CD274
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Tecentriq – Roche
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 36,915 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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29,747 adverse events reported
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