Tecentriq(atezolizumab)
Tecentriq (atezolizumab) is an antibody pharmaceutical. Atezolizumab was first approved as Tecentriq on 2016-05-18. It is used to treat non-small-cell lung carcinoma and urinary bladder neoplasms in the USA. It has been approved in Europe to treat breast neoplasms, non-small-cell lung carcinoma, small cell lung carcinoma, transitional cell carcinoma, and urologic neoplasms. The pharmaceutical is active against programmed cell death 1 ligand 1.
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Commercial
Therapeutic Areas
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EMA
Tecentriq
Drug Products
FDA
EMA
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tecentriq | Biologic Licensing Application | 2023-05-19 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| non-small-cell lung carcinoma | — | D002289 | — |
| urinary bladder neoplasms | — | D001749 | C67 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
atezolizumab, Tecentriq, Genentech, Inc. | |||
| 2029-12-09 | Orphan excl. | ||
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J9022 | Injection, atezolizumab, 10 mg |
Clinical
Clinical Trials
1418 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | 100 | 143 | 52 | 2 | 31 | 276 |
| Hepatocellular carcinoma | D006528 | — | C22.0 | 24 | 54 | 8 | 2 | 24 | 98 |
| Liver neoplasms | D008113 | EFO_1001513 | C22.0 | 27 | 36 | 11 | 2 | 19 | 83 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 23 | 35 | 7 | 2 | 5 | 56 |
| Interstitial lung diseases | D017563 | HP_0006530 | J84.89 | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 145 | 101 | 8 | — | 15 | 207 |
| Melanoma | D008545 | — | — | 49 | 48 | 5 | — | 14 | 93 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 45 | 51 | 7 | — | 2 | 86 |
| Triple negative breast neoplasms | D064726 | — | — | 33 | 33 | 11 | — | 2 | 62 |
| Colorectal neoplasms | D015179 | — | — | 28 | 31 | 7 | — | — | 54 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 27 | 24 | 5 | — | 4 | 50 |
| Urologic neoplasms | D014571 | — | C64-C68 | 22 | 24 | 4 | — | 6 | 48 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 26 | 25 | 4 | — | 3 | 44 |
| Small cell lung carcinoma | D055752 | — | — | 16 | 22 | 6 | — | 5 | 43 |
| Urinary bladder neoplasms | D001749 | — | C67 | 16 | 29 | 7 | — | — | 43 |
Show 52 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoma | D012509 | — | — | 13 | 14 | — | — | 1 | 21 |
| Squamous cell neoplasms | D018307 | — | — | 7 | 11 | — | — | 1 | 16 |
| Lymphoma | D008223 | — | C85.9 | 12 | 8 | — | — | — | 15 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 14 | 7 | — | — | — | 15 |
| Glioblastoma | D005909 | EFO_0000515 | — | 8 | 9 | — | — | — | 11 |
| Neuroendocrine tumors | D018358 | EFO_1001901 | D3A.8 | 3 | 8 | — | — | — | 9 |
| Biliary tract neoplasms | D001661 | — | C24.9 | 3 | 8 | — | — | — | 8 |
| Rectal neoplasms | D012004 | — | — | 3 | 7 | — | — | 1 | 8 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 8 | 4 | — | — | — | 8 |
| Hodgkin disease | D006689 | — | C81 | 3 | 3 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 1 | — | — | — | — | 1 |
| Leukemia | D007938 | — | C95 | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
| Myeloid leukemia | D007951 | — | C92 | 1 | — | — | — | — | 1 |
| Preleukemia | D011289 | — | — | 1 | — | — | — | — | 1 |
| Bone marrow diseases | D001855 | — | — | 1 | — | — | — | — | 1 |
| Primary myelofibrosis | D055728 | — | D47.4 | 1 | — | — | — | — | 1 |
| Polycythemia | D011086 | EFO_0005804 | D75.1 | 1 | — | — | — | — | 1 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | — | — | — | — | 1 |
Show 8 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 2 | 2 |
| Myocarditis | D009205 | — | I51.4 | — | — | — | — | 2 | 2 |
| Microbiota | D064307 | — | — | — | — | — | — | 2 | 2 |
| Metagenome | D054892 | — | — | — | — | — | — | 2 | 2 |
| Autoimmune diseases | D001327 | HP_0002960 | M30-M36 | — | — | — | — | 2 | 2 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | — | — | — | 1 | 1 |
| Budd-chiari syndrome | D006502 | EFO_1000966 | I82.0 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
| Pericarditis | D010493 | EFO_0007427 | I30 | — | — | — | — | 1 | 1 |
Show 10 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atezolizumab |
| INN | atezolizumab |
| Description | Atezolizumab, sold under the brand name Tecentriq, is a monoclonal antibody medication used to treat urothelial carcinoma, non-small cell lung cancer (NSCLC), triple-negative breast cancer (TNBC), small cell lung cancer (SCLC), hepatocellular carcinoma, and alveolar soft part sarcoma. It is a fully humanized, engineered monoclonal antibody of IgG1 isotype against the protein programmed cell death-ligand 1 (PD-L1).
|
| Classification | Antibody |
| Drug class | monoclonal antibodies |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | >5XXY:H|heavy chain of atezolizumab fab
EVQLVESGGGLVQPGGSLRLSCAASGFTFSDSWIHWVRQAPGKGLEWVAWISPYGGSTYYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCARRHWPGGFDYWGQGTLVTVSAASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWN
SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTMDPGGSHHHHHHHH
>5XXY:L|light chain of atezolizumab fab
DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYLYHPATFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Identifiers
| PDB | 5X8L, 5XXY |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL3707227 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | DB11595 |
| UNII ID | 52CMI0WC3Y (ChemIDplus, GSRS) |
Target
Agency Approved
CD274
CD274
Alternate
No data
Variants
No data
Financial
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Tecentriq – Roche
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Trends
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Safety
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Adverse Events
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13,376 adverse events reported
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