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Drug ReportsAtenolol
Atenolol
Atenolol, Tenoretic, Tenormin (atenolol) is a small molecule pharmaceutical. Atenolol was first approved as Tenormin on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
cardiovascular diseasesD002318
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Atenolol, Tenormin (discontinued: Atenolol, Tenormin)
Combinations
Atenolol chlorthalidone, Tenoretic (discontinued: Atenolol chlorthalidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
Tradename
Company
Number
Date
Products
TENORMINTWi PharmaceuticalsN-018240 RX1982-01-01
3 products, RLD, RS
Show 1 discontinued
Atenolol
+
Chlorthalidone
Tradename
Company
Number
Date
Products
TENORETIC 100TWi PharmaceuticalsN-018760 RX1984-06-08
1 products, RLD, RS
TENORETIC 50TWi PharmaceuticalsN-018760 RX1984-06-08
1 products, RLD
Labels
FDA
EMA
Brand Name
Status
Last Update
atenololANDA2025-04-07
atenolol and chlorthalidoneANDA2024-11-25
atenolol scopolamineunapproved drug other2014-10-15
tenoreticNew Drug Application2024-01-31
tenorminNew Drug Application2024-08-05
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
atrial fibrillationEFO_0000275D001281I48.0
heart failureEFO_0003144D006333I50
hypertensionEFO_0000537D006973I10
myocardial infarctionEFO_0000612D009203I21
angina pectorisEFO_0003913D000787I20
atrial flutterEFO_0003911D001282—
ventricular tachycardia—D017180I47.2
ventricular fibrillationEFO_0004287D014693I49.01
supraventricular tachycardia—D013617I47.1
glomerulonephritis—D005921N05
Show 3 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB03: Atenolol
— C07AB11: S-atenolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB03: Atenolol and thiazides
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB03: Atenolol and other diuretics
— C07CB53: Atenolol and other diuretics, combinations
— C07D: Beta blocking agents, thiazides and other diuretics
— C07DB: Beta blocking agents, selective, thiazides and other diuretics
— C07DB01: Atenolol, thiazides and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
HCPCS
No data
Clinical
Clinical Trials
130 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HypertensionD006973EFO_0000537I10—11——1
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938—C951————1
Precursor cell lymphoblastic leukemia-lymphomaD054198—C91.01————1
Philadelphia chromosomeD010677——1————1
Lymphoid leukemiaD007945—C911————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAtenolol
INNatenolol
Description
Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines, a monocarboxylic acid amide and a propanolamine.
Classification
Small molecule
Drug classbeta-blockers (propranolol type)
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC(C)NCC(O)COc1ccc(CC(N)=O)cc1
Identifiers
PDB—
CAS-ID29122-68-7
RxCUI—
ChEMBL IDCHEMBL24
ChEBI ID2904
PubChem CID2249
DrugBankDB00335
UNII ID50VV3VW0TI (ChemIDplus, GSRS)
Target
Agency Approved
ADRB1
ADRB1
Organism
Homo sapiens
Gene name
ADRB1
Gene synonyms
ADRB1R, B1AR
NCBI Gene ID
153
Protein name
beta-1 adrenergic receptor
Protein synonyms
adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor
Uniprot ID
P08588
Mouse ortholog
Adrb1 (11554)
beta-1 adrenergic receptor (P34971)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Atenolol
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Atenolol
+
Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 18,254 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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21,884 adverse events reported
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