Atenolol
Atenolol, Tenoretic, Tenormin (atenolol) is a small molecule pharmaceutical. Atenolol was first approved as Tenormin on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Atenolol, Tenormin (discontinued: Atenolol, Tenormin)
CombinationsAtenolol chlorthalidone, Tenoretic (discontinued: Atenolol chlorthalidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORMIN | TWi Pharmaceuticals | N-018240 RX | 1982-01-01 | 3 products, RLD, RS |
Show 1 discontinued
Atenolol
+
Chlorthalidone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORETIC 100 | TWi Pharmaceuticals | N-018760 RX | 1984-06-08 | 1 products, RLD, RS |
| TENORETIC 50 | TWi Pharmaceuticals | N-018760 RX | 1984-06-08 | 1 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atenolol | ANDA | 2025-04-18 |
| atenolol and chlorthalidone | ANDA | 2024-11-25 |
| atenolol scopolamine | unapproved drug other | 2014-10-15 |
| tenoretic | New Drug Application | 2024-01-31 |
| tenormin | New Drug Application | 2024-08-05 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB03: Atenolol
— C07AB11: S-atenolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB03: Atenolol and thiazides
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB03: Atenolol and other diuretics
— C07CB53: Atenolol and other diuretics, combinations
— C07D: Beta blocking agents, thiazides and other diuretics
— C07DB: Beta blocking agents, selective, thiazides and other diuretics
— C07DB01: Atenolol, thiazides and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
HCPCS
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Clinical
Clinical Trials
346 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 3 | 20 | 20 | 12 | 12 | 64 |
| Hypertension | D006973 | EFO_0000537 | I10 | 5 | 10 | 11 | 27 | 10 | 60 |
| Hyperuricemia | D033461 | — | — | 2 | 15 | 6 | 5 | 5 | 31 |
| Syndrome | D013577 | — | — | 2 | 12 | 7 | 3 | 2 | 25 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 5 | 5 | 1 | 7 | 7 | 24 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 4 | 2 | 11 | 3 | 3 | 22 |
| Chronic renal insufficiency | D051436 | — | N18 | 5 | 4 | — | 3 | 4 | 15 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 1 | 6 | 6 | 1 | 14 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 6 | 2 | 6 | — | 13 |
| Healthy volunteers/patients | — | — | — | 8 | 1 | — | 1 | 3 | 13 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 6 | 17 | 2 | — | 1 | 23 |
| Lymphoma | D008223 | — | C85.9 | 5 | 12 | 2 | — | 1 | 18 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | 11 | 1 | — | — | 14 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 3 | 8 | 2 | — | 1 | 13 |
| Neoplasms | D009369 | — | C80 | 1 | 4 | 2 | — | 1 | 8 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 2 | 2 | — | 1 | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 2 | — | 1 | 4 |
| Tumor lysis syndrome | D015275 | — | E88.3 | — | 1 | 2 | — | — | 3 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | 1 | — | 2 | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 3 | 3 | — | — | 3 |
Show 39 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 7 | — | — | 1 | 10 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 7 | — | — | — | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 5 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | 5 | — | — | — | 6 |
| Preleukemia | D011289 | — | — | 2 | 5 | — | — | — | 6 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 5 | — | — | 1 | 6 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | 5 | — | — | — | 5 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | — | 5 | — | — | — | 5 |
| Plasmacytoma | D010954 | — | C90.3 | 2 | 2 | — | — | — | 4 |
Show 50 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | 2 | 3 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 2 | — | — | — | — | 2 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Fasting | D005215 | EFO_0002756 | — | 1 | — | — | — | — | 1 |
| Vasodilation | D014664 | — | — | 1 | — | — | — | — | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | — | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | 1 | — | — | — | — | 1 |
| Intestinal diseases | D007410 | — | K63.9 | 1 | — | — | — | — | 1 |
Show 5 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | — | — | — | 1 | 1 |
| Wasting syndrome | D019282 | — | — | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | — | R64 | — | — | — | — | 1 | 1 |
| Rheumatic diseases | D012216 | — | M79.0 | — | — | — | — | 1 | 1 |
| Rheumatic fever | D012213 | EFO_1001160 | I00-I02 | — | — | — | — | 1 | 1 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 1 | 1 |
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | — | — | 1 | 1 |
| Exercise test | D005080 | EFO_0004328 | — | — | — | — | — | 1 | 1 |
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atenolol |
| INN | atenolol |
| Description | Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines, a monocarboxylic acid amide and a propanolamine. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NCC(O)COc1ccc(CC(N)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 29122-68-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL24 |
| ChEBI ID | 2904 |
| PubChem CID | 2249 |
| DrugBank | DB00335 |
| UNII ID | 50VV3VW0TI (ChemIDplus, GSRS) |
Target
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Alternate
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Estimated US medical usage
Atenolol
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Atenolol
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Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Trends
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Safety
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Adverse Events
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21,884 adverse events reported
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