Atenolol
Atenolol, Tenoretic, Tenormin (atenolol) is a small molecule pharmaceutical. Atenolol was first approved as Tenormin on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Atenolol, Tenormin (discontinued: Atenolol, Tenormin)
CombinationsAtenolol chlorthalidone, Tenoretic (discontinued: Atenolol chlorthalidone)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORMIN | TWi Pharmaceuticals | N-018240 RX | 1982-01-01 | 3 products, RLD, RS |
Show 1 discontinued
Atenolol
+
Chlorthalidone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORETIC 100 | TWi Pharmaceuticals | N-018760 RX | 1984-06-08 | 1 products, RLD, RS |
| TENORETIC 50 | TWi Pharmaceuticals | N-018760 RX | 1984-06-08 | 1 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atenolol | ANDA | 2026-10-15 |
| atenolol and chlorthalidone | ANDA | 2026-10-05 |
| atenolol scopolamine | unapproved drug other | 2014-10-15 |
| tenormin | New Drug Application | 2025-09-18 |
Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB03: Atenolol
— C07AB11: S-atenolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB03: Atenolol and thiazides
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB03: Atenolol and other diuretics
— C07CB53: Atenolol and other diuretics, combinations
— C07D: Beta blocking agents, thiazides and other diuretics
— C07DB: Beta blocking agents, selective, thiazides and other diuretics
— C07DB01: Atenolol, thiazides and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
HCPCS
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Clinical
Clinical Trials
362 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 4 | 21 | 21 | 14 | 13 | 70 |
| Hypertension | D006973 | EFO_0000537 | I10 | 5 | 9 | 12 | 28 | 11 | 62 |
| Hyperuricemia | D033461 | — | — | 2 | 16 | 8 | 8 | 6 | 38 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 4 | 1 | 11 | 4 | 3 | 22 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 6 | 2 | 8 | — | 15 |
| Chronic renal insufficiency | D051436 | — | N18 | 4 | 4 | — | 3 | 5 | 15 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 3 | 2 | 1 | 3 | 7 | 15 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | 1 | 1 | 5 | 6 | 1 | 13 |
| Healthy volunteers/patients | — | — | — | 8 | 1 | — | 1 | 3 | 13 |
| Syndrome | D013577 | — | — | — | 4 | 4 | 1 | 2 | 11 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 15 | 1 | — | 1 | 20 |
| Lymphoma | D008223 | — | C85.9 | 5 | 12 | 1 | — | 1 | 16 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 5 | 9 | 2 | — | 1 | 15 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 4 | 2 | — | 1 | 9 |
| Neoplasms | D009369 | — | C80 | 1 | 5 | 2 | — | 1 | 8 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | 5 | 1 | — | — | 7 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | 3 | 4 | — | — | 7 |
| Joint diseases | D007592 | — | M12.9 | — | 2 | 4 | — | — | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 2 | 1 | — | 2 | 5 |
| Musculoskeletal diseases | D009140 | — | — | — | — | 5 | — | — | 5 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 7 | — | — | 1 | 10 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 7 | — | — | 1 | 9 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 6 | — | — | — | 8 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 6 | — | — | — | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 5 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | 5 | — | — | — | 6 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | — | — | — | 5 |
| B-cell lymphoma marginal zone | D018442 | — | C88.4 | 2 | 4 | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 4 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | — | 5 | — | — | — | 5 |
Show 51 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 2 | — | — | — | — | 2 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 1 | — | — | — | — | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 1 | — | — | — | — | 1 |
| Immunoblastic lymphadenopathy | D007119 | EFO_1001350 | C86.5 | 1 | — | — | — | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
| Hairy cell leukemia | D007943 | — | C91.4 | 1 | — | — | — | — | 1 |
Show 14 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 2 | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | — | — | — | 2 | 2 |
| Apnea | D001049 | — | R06.81 | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Thoracic aortic aneurysm | D017545 | EFO_0004282 | — | — | — | — | — | 1 | 1 |
| Multiple endocrine neoplasia type 1 | D018761 | — | E31.21 | — | — | — | — | 1 | 1 |
| Weight loss | D015431 | — | — | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | — | R64 | — | — | — | — | 1 | 1 |
| Rheumatic fever | D012213 | EFO_1001160 | I00-I02 | — | — | — | — | 1 | 1 |
| Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atenolol |
| INN | atenolol |
| Description | Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines, a monocarboxylic acid amide and a propanolamine. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NCC(O)COc1ccc(CC(N)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 29122-68-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL24 |
| ChEBI ID | 2904 |
| PubChem CID | 2249 |
| DrugBank | DB00335 |
| UNII ID | 50VV3VW0TI (ChemIDplus, GSRS) |
Target
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Estimated US medical usage
Atenolol
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Atenolol
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Chlorthalidone
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Safety
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Adverse Events
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22,811 adverse events reported
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