Atenolol
Atenolol, Tenoretic, Tenormin (atenolol) is a small molecule pharmaceutical. Atenolol was first approved as Tenormin on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Tenormin (generic drugs available since 1988-07-15)
CombinationsTenoretic (generic drugs available since 1988-07-15)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atenolol
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORMIN | Almatica Pharma | N-018240 RX | 1982-01-01 | 3 products, RLD, RS |
Show 1 discontinued
Atenolol
+
Chlorthalidone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TENORETIC 100 | Almatica Pharma | N-018760 RX | 1984-06-08 | 1 products, RLD, RS |
| TENORETIC 50 | Almatica Pharma | N-018760 RX | 1984-06-08 | 1 products, RLD |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atenolol | ANDA | 2024-02-14 |
| atenolol and chlorthalidone | ANDA | 2024-01-16 |
| atenolol scopolamine | unapproved drug other | 2014-10-15 |
| tenoretic | New Drug Application | 2023-08-31 |
| tenormin | New Drug Application | 2023-08-31 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C07: Beta-adrenergic blocking agents
— C07A: Beta blocking agents
— C07AB: Beta blocking agents, selective
— C07AB03: Atenolol
— C07AB11: S-atenolol
— C07B: Beta blocking agents and thiazides
— C07BB: Beta blocking agents, selective, and thiazides
— C07BB03: Atenolol and thiazides
— C07C: Beta blocking agents and other diuretics
— C07CB: Beta blocking agents, selective, and other diuretics
— C07CB03: Atenolol and other diuretics
— C07CB53: Atenolol and other diuretics, combinations
— C07D: Beta blocking agents, thiazides and other diuretics
— C07DB: Beta blocking agents, selective, thiazides and other diuretics
— C07DB01: Atenolol, thiazides and other diuretics
— C07F: Beta blocking agents, other combinations
— C07FB: Beta blocking agents and calcium channel blockers
— C07FB03: Atenolol and nifedipine
HCPCS
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Clinical
Clinical Trials
128 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 4 | 3 | 8 | 23 | 9 | 46 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 7 | 2 | 2 | 11 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 4 | 5 | — | 9 |
| Marfan syndrome | D008382 | Orphanet_558 | Q87.4 | — | 2 | 5 | 1 | — | 8 |
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | 1 | 3 | 7 |
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | — | 1 | 1 | 4 | 6 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | 2 | 2 | 5 |
| Blood pressure | D001794 | EFO_0004325 | — | 1 | — | — | 3 | — | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | 1 | 2 | 1 | 4 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | 3 | — | 4 |
Show 24 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Left ventricular hypertrophy | D017379 | EFO_0003896 | — | — | — | 3 | — | — | 3 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | 1 | 2 |
| Cerebral small vessel diseases | D059345 | — | — | — | — | 1 | — | — | 1 |
| Mitral valve stenosis | D008946 | EFO_0007372 | — | — | — | 1 | — | — | 1 |
| Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | 1 | — | — | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | — | 1 | — | — | 1 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | — | 1 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | 1 | — | — | 1 |
| Hemangioma | D006391 | — | D18.0 | — | — | 1 | — | — | 1 |
| Medication adherence | D055118 | EFO_0006344 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pheochromocytoma | D010673 | — | — | — | 1 | — | — | — | 1 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | 1 | — | — | — | 1 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | 1 | — | — | — | 1 |
| Vestibular diseases | D015837 | EFO_0009691 | H81 | — | 1 | — | — | — | 1 |
| Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | 1 | — | — | — | 1 |
| Orthostatic intolerance | D054971 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 2 | — | — | — | — | 2 |
| Morbid obesity | D009767 | EFO_0001074 | — | 1 | — | — | — | — | 1 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 2 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Aneurysm | D000783 | HP_0002617 | I72.9 | — | — | — | — | 1 | 1 |
| Cachexia | D002100 | HP_0004326 | R64 | — | — | — | — | 1 | 1 |
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | — | 1 | 1 |
| Exercise test | D005080 | EFO_0004328 | — | — | — | — | — | 1 | 1 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | — | — | — | — | 1 | 1 |
| Orthognathic surgery | D057909 | — | — | — | — | — | — | 1 | 1 |
| Pregnancy rate | D018873 | — | — | — | — | — | — | 1 | 1 |
| Low cardiac output | D002303 | — | — | — | — | — | — | 1 | 1 |
Show 4 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atenolol |
| INN | atenolol |
| Description | Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines, a monocarboxylic acid amide and a propanolamine. |
| Classification | Small molecule |
| Drug class | beta-blockers (propranolol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(C)NCC(O)COc1ccc(CC(N)=O)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 29122-68-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL24 |
| ChEBI ID | 2904 |
| PubChem CID | 2249 |
| DrugBank | DB00335 |
| UNII ID | 50VV3VW0TI (ChemIDplus, GSRS) |
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Estimated US medical usage
Atenolol
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Atenolol
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Chlorthalidone
Total medical expenditures per year (USD, in millions)
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Trends
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Safety
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Adverse Events
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19,136 adverse events reported
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