Atenolol - PharmaKB

Atenolol

Atenolol, Tenoretic, Tenormin (atenolol) is a small molecule pharmaceutical. Atenolol was first approved as Tenormin on 1982-01-01. It is used to treat angina pectoris, atrial fibrillation, atrial flutter, heart failure, and hypertension amongst others in the USA. The pharmaceutical is active against beta-1 adrenergic receptor. In addition, it is known to target beta-2 adrenergic receptor.

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Events Timeline

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Events

FDA approval date

EMA approval date

Patent expiration date

Study first post date

Last update post date

Start date

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Completion date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
cardiovascular diseases	D002318
signs and symptoms pathological conditions	D013568

Trade Name

FDA

EMA

Atenolol, Tenormin (discontinued: Atenolol, Tenormin)

Combinations

Atenolol chlorthalidone, Tenoretic (discontinued: Atenolol chlorthalidone)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Atenolol

Tradename	Company	Number	Date	Products
TENORMIN	TWi Pharmaceuticals	N-018240 RX	1982-01-01	3 products, RLD, RS

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Atenolol

Chlorthalidone

Tradename	Company	Number	Date	Products
TENORETIC 100	TWi Pharmaceuticals	N-018760 RX	1984-06-08	1 products, RLD, RS
TENORETIC 50	TWi Pharmaceuticals	N-018760 RX	1984-06-08	1 products, RLD

Labels

FDA

EMA

Brand Name	Status	Last Update
atenolol	ANDA	2025-10-01
atenolol and chlorthalidone	ANDA	2025-09-25
atenolol scopolamine	unapproved drug other	2014-10-15
tenoretic	New Drug Application	2024-01-31
tenormin	New Drug Application	2024-08-05

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
atrial fibrillation	EFO_0000275	D001281	I48.0
heart failure	EFO_0003144	D006333	I50
hypertension	EFO_0000537	D006973	I10
myocardial infarction	EFO_0000612	D009203	I21
angina pectoris	EFO_0003913	D000787	I20
atrial flutter	EFO_0003911	D001282	—
ventricular tachycardia	—	D017180	I47.2
ventricular fibrillation	EFO_0004287	D014693	I49.01
supraventricular tachycardia	—	D013617	I47.1
glomerulonephritis	—	D005921	N05

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Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

C: Cardiovascular system drugs

— C07: Beta-adrenergic blocking agents

— C07A: Beta blocking agents

— C07AB: Beta blocking agents, selective

— C07AB03: Atenolol

— C07AB11: S-atenolol

— C07B: Beta blocking agents and thiazides

— C07BB: Beta blocking agents, selective, and thiazides

— C07BB03: Atenolol and thiazides

— C07C: Beta blocking agents and other diuretics

— C07CB: Beta blocking agents, selective, and other diuretics

— C07CB03: Atenolol and other diuretics

— C07CB53: Atenolol and other diuretics, combinations

— C07D: Beta blocking agents, thiazides and other diuretics

— C07DB: Beta blocking agents, selective, thiazides and other diuretics

— C07DB01: Atenolol, thiazides and other diuretics

— C07F: Beta blocking agents, other combinations

— C07FB: Beta blocking agents and calcium channel blockers

— C07FB03: Atenolol and nifedipine

HCPCS

No data

Clinical

Clinical Trials

131 clinical trials

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Indications Phases 4

No data

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Hypertension	D006973	EFO_0000537	I10	1	1	1	—	—	3

Indications Phases 2

No data

Indications Phases 1

No data

Indications Without Phase

No data

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	Atenolol
INN	atenolol
Description	Atenolol is an ethanolamine compound having a (4-carbamoylmethylphenoxy)methyl group at the 1-position and an N-isopropyl substituent. It has a role as a beta-adrenergic antagonist, an anti-arrhythmia drug, an antihypertensive agent, a sympatholytic agent, a xenobiotic and an environmental contaminant. It is a member of ethanolamines, a monocarboxylic acid amide and a propanolamine.
Classification	Small molecule
Drug class	beta-blockers (propranolol type)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(C)NCC(O)COc1ccc(CC(N)=O)cc1

Identifiers

PDB	—
CAS-ID	29122-68-7
RxCUI	—
ChEMBL ID	CHEMBL24
ChEBI ID	2904
PubChem CID	2249
DrugBank	DB00335
UNII ID	50VV3VW0TI (ChemIDplus, GSRS)

Target

Agency Approved

ADRB1

Organism

Homo sapiens

Gene name

ADRB1

Gene synonyms

ADRB1R, B1AR

NCBI Gene ID

153

Protein name

beta-1 adrenergic receptor

Protein synonyms

adrenergic, beta-1-, receptor, Beta-1 adrenoceptor, Beta-1 adrenoreceptor

Uniprot ID

P08588

Mouse ortholog

Adrb1 (11554)

beta-1 adrenergic receptor (P34971)

Alternate

No data

Variants

No data

Financial

Revenue by drug

€

₣

No data

Estimated US medical usage

Atenolol

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Atenolol

Chlorthalidone

Total medical expenditures per year (USD, in millions)

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Number of persons purchased

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Number of purchases

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Refill frequency

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Price per prescription (USD)

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Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Additional graphs summarizing 18,866 documents

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Safety

Black-box Warning

No Black-box warning

Adverse Events

Top Adverse Reactions

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22,336 adverse events reported

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