Reyataz(atazanavir)
Atazanavir, Evotaz, Reyataz (atazanavir) is a small molecule pharmaceutical. Atazanavir was first approved as Reyataz on 2003-06-20. It is used to treat acquired immunodeficiency syndrome in the USA. It has been approved in Europe to treat HIV infections.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| urogenital diseases | D000091642 |
| immune system diseases | D007154 |
Trade Name
FDA
EMA
Atazanavir, Reyataz (discontinued: Atazanavir, Reyataz)
CombinationsEvotaz
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Atazanavir sulfate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| REYATAZ | Bristol Myers Squibb | N-021567 RX | 2003-06-20 | 2 products, RLD |
| REYATAZ | Bristol Myers Squibb | N-206352 RX | 2014-06-02 | 1 products, RLD, RS |
Show 1 discontinued
Atazanavir sulfate
+
Cobicistat
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| EVOTAZ | Bristol Myers Squibb | N-206353 RX | 2015-01-29 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| atazanavir | ANDA | 2024-04-24 |
| atazanavir sulfate | ANDA | 2024-09-17 |
| evotaz | New Drug Application | 2023-05-12 |
| reyataz | New Drug Application | 2023-11-07 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| acquired immunodeficiency syndrome | EFO_0000765 | D000163 | B20 |
| hiv infections | EFO_0000764 | D015658 | B20 |
Agency Specific
FDA
EMA
No data
ATC Codes
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AE: Protease inhibitors, direct acting antivirals
— J05AE08: Atazanavir
— J05AR: Antivirals for treatment of hiv infections, combinations
— J05AR15: Atazanavir and cobicistat
— J05AR23: Atazanavir and ritonavir
HCPCS
No data
Clinical
Clinical Trials
248 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 22 | 33 | 55 | 40 | 33 | 174 |
| Hiv | D006678 | — | — | 7 | 5 | 11 | 12 | 14 | 47 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | 2 | 9 | 14 | 4 | 8 | 34 |
| Infections | D007239 | EFO_0000544 | — | — | 7 | 8 | 4 | 3 | 20 |
| Immunologic deficiency syndromes | D007153 | HP_0002721 | D84.9 | — | 5 | 10 | 1 | 1 | 14 |
| Hepatitis c | D006526 | — | B19.2 | 3 | 4 | 3 | 2 | 1 | 11 |
| Communicable diseases | D003141 | — | — | — | 4 | 6 | 2 | — | 10 |
| Healthy volunteers/patients | — | — | — | 9 | — | — | 1 | — | 10 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | 3 | 4 | 3 | 1 | 1 | 10 |
| Hiv-1 | D015497 | — | — | 2 | 3 | 2 | 2 | 2 | 10 |
Show 14 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 1 | 2 | 2 | — | 1 | 5 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 1 | 1 | — | 3 | 4 |
| Covid-19 | D000086382 | — | — | — | 3 | 2 | — | — | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | 1 | — | — | 2 |
| Fibrosis | D005355 | — | — | — | 2 | 1 | — | — | 2 |
| Hepatitis b | D006509 | — | — | — | 1 | 1 | — | 1 | 2 |
| Coinfection | D060085 | — | — | — | 2 | 1 | — | — | 2 |
| Hyperlipidemias | D006949 | HP_0003077 | E78.5 | — | — | 2 | — | — | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | 1 | 1 | — | — | 1 |
| Coronavirus infections | D018352 | EFO_0007224 | B34.2 | — | 1 | 1 | — | — | 1 |
Show 5 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Viremia | D014766 | — | B34.9 | — | 2 | — | — | — | 2 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 1 | — | — | — | 2 |
| Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 1 | — | — | — | 1 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hyperbilirubinemia | D006932 | — | — | 1 | — | — | — | 2 | 3 |
| Hematologic neoplasms | D019337 | — | — | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | — | — | 1 |
| Toxoplasmosis | D014123 | EFO_0007517 | B58 | 1 | — | — | — | — | 1 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | — | — | — | 1 |
| Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Nephrolithiasis | D053040 | — | N20.0 | — | — | — | — | 1 | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | — | — | 1 | 1 |
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Hiv seropositivity | D006679 | — | — | — | — | — | — | 1 | 1 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | — | — | — | 1 | 1 |
| Pregnancy | D011247 | EFO_0002950 | Z33.1 | — | — | — | — | 1 | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | — | — | 1 | 1 |
| Female genital diseases | D005831 | EFO_0009549 | N85 | — | — | — | — | 1 | 1 |
| Genital diseases | D000091662 | — | — | — | — | — | — | 1 | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | — | — | 1 | 1 |
Show 6 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atazanavir |
| INN | atazanavir |
| Description | Atazanavir is a heavily substituted carbohydrazide that is an antiretroviral drug of the protease inhibitor (PI) class used to treat infection of human immunodeficiency virus (HIV). It has a role as an antiviral drug and a HIV protease inhibitor. |
| Classification | Small molecule |
| Drug class | antivirals: HIV protease inhibitors (saquinavir type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(-c2ccccn2)cc1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C |
Identifiers
| PDB | — |
| CAS-ID | 198904-31-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1163 |
| ChEBI ID | 37924 |
| PubChem CID | 148192 |
| DrugBank | DB01072 |
| UNII ID | QZU4H47A3S (ChemIDplus, GSRS) |
Target
No data
Variants
No data
Financial
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Reyataz – Bristol Myers Squibb
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Estimated US medical usage
Atazanavir
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 8,762 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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13,992 adverse events reported
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