Atabecestat
Atabecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target beta-secretase 1 and beta-secretase 2.
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Clinical
Drug
Target
Variants
Financial
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Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Alzheimer disease | D000544 | EFO_0000249 | F03 | 3 | 3 | 1 | — | — | 6 |
| Dementia | D003704 | EFO_0003862 | F03 | 1 | 1 | 1 | — | — | 2 |
| Asymptomatic diseases | D058070 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
No data
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 9 | — | — | — | — | 9 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Atabecestat |
| INN | atabecestat |
| Description | Atabecestat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target beta-secretase 1 and beta-secretase 2. |
| Classification | Small molecule |
| Drug class | enzyme inhibitors: beta secretase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@]1(c2cc(NC(=O)c3ccc(C#N)cn3)ccc2F)C=CSC(N)=N1 |
Identifiers
| PDB | — |
| CAS-ID | 1200493-78-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3916243 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | 2834W8D6GK (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
BACE1
BACE1
BACE2
BACE2
Organism
Homo sapiens
Gene name
BACE1
Gene synonyms
BACE, KIAA1149
NCBI Gene ID
Protein name
beta-secretase 1
Protein synonyms
APP beta-secretase, Asp 2, ASP2, Aspartyl protease 2, beta-site amyloid beta A4 precursor protein-cleaving enzyme, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, beta-site APP-cleaving enzyme, Memapsin-2, Membrane-associated aspartic protease 2, transmembrane aspartic proteinase Asp2
Uniprot ID
Mouse ortholog
Bace1 (23821)
beta-secretase 1 (Q544D0)
Variants
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 235 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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