Asunaprevir
Asunaprevir is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical
Clinical Trials
116 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | — | B19.2 | 12 | 16 | 12 | 3 | 10 | 52 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | 1 | 12 | 10 | 2 | 8 | 32 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | 1 | 8 | 6 | 2 | 6 | 22 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | 6 | 6 | 1 | 7 | 20 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | — | 1 | 15 | 16 |
| Respiratory distress syndrome | D012128 | EFO_1000637 | J80 | — | — | — | 1 | 4 | 5 |
| Newborn respiratory distress syndrome | D012127 | — | P22 | — | — | — | 1 | 4 | 5 |
| Respiratory insufficiency | D012131 | HP_0002093 | J96.9 | — | — | 1 | 1 | 2 | 4 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | 1 | 3 | 4 |
| Cheyne-stokes respiration | D002639 | — | R06.3 | — | — | — | 1 | 3 | 4 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepacivirus | D016174 | — | — | 1 | 1 | 3 | — | — | 5 |
| Hepatitis b | D006509 | — | — | — | 1 | 2 | — | — | 3 |
| Self efficacy | D020377 | — | — | — | — | 1 | — | — | 1 |
| Ventilator weaning | D015300 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | — | 2 | — | — | 21 | 23 |
| Apnea | D001049 | HP_0002104 | R06.81 | — | 2 | — | — | 12 | 14 |
| Chronic hepatitis | D006521 | — | K73.9 | — | 2 | — | — | 4 | 6 |
| Infections | D007239 | EFO_0000544 | — | — | 4 | — | — | — | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | — | — | 2 | 3 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | — | 2 | — | — | — | 2 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 1 | — | — | 1 | 2 |
| Fibrosis | D005355 | — | — | — | 1 | — | — | 1 | 2 |
| Communicable diseases | D003141 | — | — | — | 2 | — | — | — | 2 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 2 | — | — | — | — | 2 |
| Liver failure | D017093 | HP_0001399 | K72.9 | 1 | — | — | — | — | 1 |
| Hepatic insufficiency | D048550 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Central sleep apnea | D020182 | — | G47.31 | — | — | — | — | 10 | 10 |
| Respiratory aspiration | D053120 | EFO_1001839 | — | — | — | — | — | 8 | 8 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | — | — | — | — | 7 | 7 |
| Syndrome | D013577 | — | — | — | — | — | — | 7 | 7 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 5 | 5 |
| Acute lung injury | D055371 | EFO_0004610 | — | — | — | — | — | 4 | 4 |
| Obstructive lung diseases | D008173 | HP_0006536 | — | — | — | — | — | 4 | 4 |
| Artificial respiration | D012121 | — | — | — | — | — | — | 3 | 3 |
| Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | — | — | 3 | 3 |
| Postoperative care | D011182 | — | — | — | — | — | — | 2 | 2 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Asunaprevir |
| INN | asunaprevir |
| Description | Asunaprevir is an oligopeptide. |
| Classification | Small molecule |
| Drug class | antivirals: serine protease inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2ncc(OC)c3ccc(Cl)cc23)CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1 |
Identifiers
| PDB | — |
| CAS-ID | 630420-16-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2105735 |
| ChEBI ID | — |
| PubChem CID | 16076883 |
| DrugBank | DB11586 |
| UNII ID | S9X0KRJ00S (ChemIDplus, GSRS) |
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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80,205 adverse events reported
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