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Drug ReportsAspartame
Aspartame
Aspartame is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Events Timeline
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New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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FDA
EMA
Brand Name
Status
Last Update
discount drug mart eye drops advanced reliefOTC monograph final2023-03-20
equalactin laxativeC2002632023-12-18
equalineOTC monograph not final2019-02-15
equaline 12 hour decongestantANDA2023-08-03
equaline acetaminophenC2002632024-11-13
equaline adult tussinC2002632024-11-10
equaline advanced relief eye dropsC2002632023-12-20
equaline all day allergyANDA2023-08-02
equaline allergyC2002632024-09-29
equaline allergy reliefANDA2023-07-24
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Indications
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Clinical
Clinical Trials
88 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ColonoscopyD003113—————112
Indications Phases 3
Indication
MeSH
Ontology
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Ph 2
Ph 3
Ph 4
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Total
Covid-19D000086382————1——1
Pyruvate dehydrogenase complex deficiency diseaseD015325EFO_0007459E74.4——1——1
SepsisD018805HP_0100806A41.9—11——1
MalnutritionD044342EFO_0008572E40-E46—11——1
Child nutrition disordersD015362———11——1
Indications Phases 2
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Ontology
ICD-10
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Healthy volunteers/patients———21——57
XerostomiaD014987—K11.711——23
Sjogren's syndromeD012859EFO_0000699M35.011——12
OtotoxicityD000081015———1———1
MucositisD052016EFO_1001898——1———1
GlioblastomaD005909EFO_0000515——1———1
Indications Phases 1
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HivD006678——1————1
BronchiectasisD001987HP_0002110J471————1
Escherichia coli infectionsD004927EFO_1001318B96.201————1
GastroenteritisD005759EFO_1001463K52.91————1
PharmacokineticsD010599——1————1
Dental plaqueD003773——1————1
Hydrogen-ion concentrationD006863——1————1
SalivationD012472——1————1
Indications Without Phase
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ObesityD009765EFO_0001073E66.9————1313
Type 2 diabetes mellitusD003924EFO_0001360E11————77
OverweightD050177—E66.3————77
Diabetes mellitusD003920HP_0000819E08-E13————66
Glucose intoleranceD018149HP_0000833R73.03————55
Body weightD001835EFO_0004338—————55
Insulin resistanceD007333HP_0000855—————55
Metabolic syndromeD024821EFO_0000195E88.810————44
Weight lossD015431HP_0001824—————33
Feeding behaviorD005247——————33
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAspartame
INNaspartame
Description
Aspartame is a dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. It has a role as a sweetening agent, a nutraceutical, a micronutrient, a xenobiotic, an environmental contaminant, an apoptosis inhibitor and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is a dipeptide, a carboxylic acid and a methyl ester. It is functionally related to a L-aspartic acid and a methyl L-phenylalaninate. It is a tautomer of an aspartame zwitterion.
Classification
Small molecule
Drug class—
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Structure (InChI/SMILES or Protein Sequence)
COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O
Identifiers
PDB—
CAS-ID22839-47-0
RxCUI—
ChEMBL IDCHEMBL171679
ChEBI ID2877
PubChem CID134601
DrugBankDB00168
UNII IDZ0H242BBR1 (ChemIDplus, GSRS)
Target
No data
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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2,365 adverse events reported
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