Aspartame
Aspartame is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Brand Name | Status | Last Update |
|---|---|---|
| discount drug mart eye drops advanced relief | OTC monograph final | 2023-03-20 |
| equalactin laxative | C200263 | 2024-12-18 |
| equaline | OTC monograph not final | 2019-02-15 |
| equaline 12 hour decongestant | ANDA | 2023-08-03 |
| equaline acetaminophen | C200263 | 2024-11-13 |
| equaline adult tussin | C200263 | 2024-11-10 |
| equaline advanced relief eye drops | C200263 | 2023-12-20 |
| equaline all day allergy | ANDA | 2023-08-02 |
| equaline allergy | C200263 | 2024-09-29 |
| equaline allergy relief | ANDA | 2024-12-10 |
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Clinical
Clinical Trials
90 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 1 | 1 | — | — | 2 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | 2 | — | — | 2 |
| Sclerosis | D012598 | — | — | — | — | 2 | — | — | 2 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | — | — | 1 | — | — | 1 |
| Neoplasms | D009369 | — | C80 | — | — | 1 | — | — | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | 1 | — | — | 1 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | — | — | 1 | — | — | 1 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | — | — | 1 | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | 1 | — | — | 1 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
| Neoplasm metastasis | D009362 | EFO_0009708 | — | — | 1 | — | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | — | 1 | — | — | — | 1 |
| Nephritis | D009393 | — | N05 | — | 1 | — | — | — | 1 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aspartame |
| INN | aspartame |
| Description | Aspartame is a dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. It has a role as a sweetening agent, a nutraceutical, a micronutrient, a xenobiotic, an environmental contaminant, an apoptosis inhibitor and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is a dipeptide, a carboxylic acid and a methyl ester. It is functionally related to a L-aspartic acid and a methyl L-phenylalaninate. It is a tautomer of an aspartame zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 22839-47-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL171679 |
| ChEBI ID | 2877 |
| PubChem CID | 134601 |
| DrugBank | DB00168 |
| UNII ID | Z0H242BBR1 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,562 adverse events reported
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