Aspartame
Aspartame is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| discount drug mart eye drops advanced relief | OTC monograph final | 2023-03-20 |
| equalactin laxative | C200263 | 2023-12-18 |
| equaline | OTC monograph not final | 2019-02-15 |
| equaline 12 hour decongestant | ANDA | 2023-08-03 |
| equaline acetaminophen | C200263 | 2024-10-02 |
| equaline adult tussin | OTC monograph final | 2023-08-21 |
| equaline advanced relief eye drops | C200263 | 2023-12-20 |
| equaline all day allergy | ANDA | 2023-08-02 |
| equaline allergy | C200263 | 2024-09-29 |
| equaline allergy relief | ANDA | 2023-07-24 |
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Clinical
Clinical Trials
88 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Colonoscopy | D003113 | — | — | — | — | — | 1 | 1 | 2 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | — | — | — | 1 | — | — | 1 |
| Pyruvate dehydrogenase complex deficiency disease | D015325 | EFO_0007459 | E74.4 | — | — | 1 | — | — | 1 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | 1 | 1 | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | 1 | 1 | — | — | 1 |
| Child nutrition disorders | D015362 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | 1 | — | — | 5 | 7 |
| Xerostomia | D014987 | — | K11.7 | 1 | 1 | — | — | 2 | 3 |
| Sjogren's syndrome | D012859 | EFO_0000699 | M35.0 | 1 | 1 | — | — | 1 | 2 |
| Ototoxicity | D000081015 | — | — | — | 1 | — | — | — | 1 |
| Mucositis | D052016 | EFO_1001898 | — | — | 1 | — | — | — | 1 |
| Glioblastoma | D005909 | EFO_0000515 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv | D006678 | — | — | 1 | — | — | — | — | 1 |
| Bronchiectasis | D001987 | HP_0002110 | J47 | 1 | — | — | — | — | 1 |
| Escherichia coli infections | D004927 | EFO_1001318 | B96.20 | 1 | — | — | — | — | 1 |
| Gastroenteritis | D005759 | EFO_1001463 | K52.9 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Dental plaque | D003773 | — | — | 1 | — | — | — | — | 1 |
| Hydrogen-ion concentration | D006863 | — | — | 1 | — | — | — | — | 1 |
| Salivation | D012472 | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | — | — | — | — | 13 | 13 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 7 | 7 |
| Overweight | D050177 | — | E66.3 | — | — | — | — | 7 | 7 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 6 | 6 |
| Glucose intolerance | D018149 | HP_0000833 | R73.03 | — | — | — | — | 5 | 5 |
| Body weight | D001835 | EFO_0004338 | — | — | — | — | — | 5 | 5 |
| Insulin resistance | D007333 | HP_0000855 | — | — | — | — | — | 5 | 5 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | — | — | — | 4 | 4 |
| Weight loss | D015431 | HP_0001824 | — | — | — | — | — | 3 | 3 |
| Feeding behavior | D005247 | — | — | — | — | — | — | 3 | 3 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aspartame |
| INN | aspartame |
| Description | Aspartame is a dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. It has a role as a sweetening agent, a nutraceutical, a micronutrient, a xenobiotic, an environmental contaminant, an apoptosis inhibitor and an EC 3.1.3.1 (alkaline phosphatase) inhibitor. It is a dipeptide, a carboxylic acid and a methyl ester. It is functionally related to a L-aspartic acid and a methyl L-phenylalaninate. It is a tautomer of an aspartame zwitterion. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 22839-47-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL171679 |
| ChEBI ID | 2877 |
| PubChem CID | 134601 |
| DrugBank | DB00168 |
| UNII ID | Z0H242BBR1 (ChemIDplus, GSRS) |
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Safety
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Adverse Events
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2,365 adverse events reported
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