Asoprisnil
Asoprisnil is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target progesterone receptor.
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Commercial
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Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leiomyoma | D007889 | HP_0000131 | D25 | — | 3 | 6 | — | — | 9 |
| Myofibroma | D047708 | — | — | — | 3 | 6 | — | — | 9 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | 6 | — | — | 6 |
| Metrorrhagia | D008796 | HP_0100608 | N92.1 | — | — | 6 | — | — | 6 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Endometriosis | D004715 | EFO_0001065 | N80 | — | 3 | — | — | — | 3 |
| Postmenopause | D017698 | — | — | — | 2 | — | — | — | 2 |
| Amenorrhea | D000568 | — | N91.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Asoprisnil |
| INN | asoprisnil |
| Description | Asoprisnil (INN; developmental code name J-867) is a synthetic, steroidal selective progesterone receptor modulator that was under development by Schering and TAP Pharmaceutical Products for the treatment of uterine fibroids. In 2005, phase III clinical trials were discontinued due to endometrial changes in patients.
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| Classification | Small molecule |
| Drug class | steriodal compounds acting on progesterone receptors (excluding-gest- compounds); selective progesterone receptor modulators (SPRM) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COC[C@]1(OC)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@@H](c3ccc(/C=N/O)cc3)C[C@@]21C |
Identifiers
| PDB | — |
| CAS-ID | 199396-76-4 |
| RxCUI | — |
| ChEMBL ID | CHEMBL267431 |
| ChEBI ID | — |
| PubChem CID | 9577221 |
| DrugBank | — |
| UNII ID | 72W09924WP (ChemIDplus, GSRS) |
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Additional graphs summarizing 266 documents
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Safety
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Adverse Events
0 adverse events reported
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