Arbaclofen
Arbaclofen is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target gamma-aminobutyric acid type B receptor subunit 1.
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Commercial
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Clinical
Clinical Trials
37 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 1 | — | 1 |
| Hemiplegia | D006429 | — | G81.0 | — | — | — | 1 | — | 1 |
| Opioid-related disorders | D009293 | EFO_0005611 | F11 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Autism spectrum disorder | D000067877 | — | F84.0 | — | 5 | 2 | — | 1 | 8 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 2 | 4 | 1 | — | 1 | 8 |
| Fragile x syndrome | D005600 | — | Q99.2 | — | 2 | 3 | — | 2 | 7 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | — | — | 6 | — | — | 6 |
| Muscle spasticity | D009128 | — | — | — | — | 5 | — | — | 5 |
| Charcot-marie-tooth disease | D002607 | EFO_0004148 | G60.0 | — | — | 3 | — | — | 3 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | — | — | 1 | — | 1 | 2 |
| Nerve compression syndromes | D009408 | — | — | — | — | 1 | — | — | 1 |
| Tooth diseases | D014076 | — | — | — | — | 1 | — | — | 1 |
| Hereditary sensory and motor neuropathy | D015417 | — | G60.0 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | 3 | — | — | — | 3 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 2 | — | — | — | 2 |
| Peptic esophagitis | D004942 | EFO_1001095 | — | — | 1 | — | — | — | 1 |
| Social adjustment | D012917 | — | — | — | 1 | — | — | — | 1 |
| Back pain | D001416 | — | M54 | — | 1 | — | — | — | 1 |
| 22q11 deletion syndrome | D058165 | Orphanet_567 | D82.1 | — | 1 | — | — | — | 1 |
| Asperger syndrome | D020817 | EFO_0003757 | F84.5 | — | 1 | — | — | — | 1 |
| Alcohol drinking | D000428 | EFO_0004329 | — | — | 1 | — | — | — | 1 |
| Mental disorders | D001523 | EFO_0000677 | F91.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syndrome | D013577 | — | — | — | — | — | — | 1 | 1 |
| Cerebral palsy | D002547 | — | G80 | — | — | — | — | 1 | 1 |
| Dystonic disorders | D020821 | — | G24 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Arbaclofen |
| INN | arbaclofen |
| Description | Arbaclofen placarbil (/ɑːrˈbækloʊfɛn pləˈkɑːrbɪl/ ar-BAK-loh-fen plə-KAR-bil, also known as XP19986) is a prodrug of R-baclofen. Arbaclofen placarbil possesses more favorable pharmacokinetic profile than baclofen, with less fluctuations in plasma drug levels. It was being developed as a potential treatment for patients with GERD and spasticity due to multiple sclerosis; however, in May 2013 XenoPort announced the termination of development because of unsuccessful results in phase III clinical trials.
|
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NC[C@H](CC(=O)O)c1ccc(Cl)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 69308-37-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL301742 |
| ChEBI ID | — |
| PubChem CID | 11281011 |
| DrugBank | DB08891 |
| UNII ID | NYU6UTW25B (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
GABBR1
GABBR1
Organism
Homo sapiens
Gene name
GABBR1
Gene synonyms
GPRC3A
NCBI Gene ID
Protein name
gamma-aminobutyric acid type B receptor subunit 1
Protein synonyms
GABA-B receptor, R1 subunit, gamma-aminobutyric acid (GABA) B receptor, 1, seven transmembrane helix receptor
Uniprot ID
Mouse ortholog
Gabbr1 (54393)
gamma-aminobutyric acid type B receptor subunit 1 (Q9WV18)
Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
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