Emend(aprepitant)
Aponvie, Aprepitant, Cinvanti, Emend (aprepitant) is a small molecule pharmaceutical. Aprepitant was first approved as Emend on 2003-03-26. It has been approved in Europe to treat neoplasms, postoperative nausea and vomiting, and vomiting. The pharmaceutical is active against substance-P receptor.
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Target
Variants
Financial
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Safety
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
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Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Aponvie, Aprepitant, Cinvanti, Emend (discontinued: Emend)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aprepitant
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| APONVIE | Heron Therapeutics | N-216457 RX | 2022-09-16 | 1 products, RLD, RS |
| CINVANTI | Heron Therapeutics | N-209296 RX | 2017-11-09 | 1 products, RLD, RS |
| EMEND | Merck & Co | N-021549 RX | 2003-03-26 | 2 products, RLD, RS |
| EMEND | Merck & Co | N-207865 RX | 2015-12-17 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aponvie | New Drug Application | 2024-03-13 |
| aprepitant | ANDA | 2024-09-09 |
| aprepitant aprepitant | ANDA | 2024-10-02 |
| cinvanti | New Drug Application | 2024-03-13 |
| emend | New Drug Application | 2024-07-05 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Aprepitant, Aponvie, Heron Theraps Inc | |||
| 9561229 | 2035-09-18 | DP | U-2161, U-3440 |
| 9808465 | 2035-09-18 | U-2161, U-3440 | |
| 9974742 | 2035-09-18 | DP | |
| 9974793 | 2035-09-18 | DP | |
| 9974794 | 2035-09-18 | DP | U-2161, U-3440 |
| 10500208 | 2035-09-18 | DP | |
| 10624850 | 2035-09-18 | U-2161, U-3440 | |
| 10953018 | 2035-09-18 | U-2161, U-3440 | |
| 11173118 | 2035-09-18 | DP | |
| Aprepitant, Emend, Merck | |||
| 8258132 | 2027-09-26 | DP | U-901, U-1743, U-1916 |
Clinical
No data
Drug
General
| Drug common name | Aprepitant |
| INN | aprepitant |
| Description | Aprepitant is a morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. It has a role as an antidepressant, an antiemetic, a peripheral nervous system drug, a neurokinin-1 receptor antagonist and a substance P receptor antagonist. It is a member of triazoles, a member of morpholines, a cyclic acetal and a member of (trifluoromethyl)benzenes. |
| Classification | Small molecule |
| Drug class | tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 170729-80-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1471 |
| ChEBI ID | 499361 |
| PubChem CID | 135413536 |
| DrugBank | DB00673 |
| UNII ID | 1NF15YR6UY (ChemIDplus, GSRS) |
Target
Agency Approved
TACR1
TACR1
Organism
Homo sapiens
Gene name
TACR1
Gene synonyms
NK1R, TAC1R
NCBI Gene ID
Protein name
substance-P receptor
Protein synonyms
neurokinin receptor 1, NK-1 receptor, NK-1R, Tachykinin receptor 1, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Uniprot ID
Mouse ortholog
Tacr1 (21336)
substance-P receptor (Q8BYR7)
Alternate
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Emend – Merck & Co
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Cinvanti – Heron Therapeutics /de/
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Aponvie – Heron Therapeutics /de/
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Estimated US medical usage
Aprepitant
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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