Therapeutic Area | MeSH |
---|---|
neoplasms | D009369 |
signs and symptoms pathological conditions | D013568 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CINVANTI | Heron Therapeutics | N-209296 RX | 2017-11-09 | 1 products, RLD, RS |
APONVIE | Heron Therapeutics | N-216457 RX | 2022-09-16 | 1 products, RLD, RS |
EMEND | Merck KGaA | N-021549 RX | 2003-03-26 | 2 products, RLD, RS |
EMEND | Merck Sharp & Dohme | N-207865 RX | 2015-12-17 | 1 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
aponvie | New Drug Application | 2023-09-14 |
aprepitant | ANDA | 2020-12-24 |
aprepitant aprepitant | ANDA | 2022-07-08 |
cinvanti | New Drug Application | 2023-09-14 |
emend | New Drug Application | 2023-12-01 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Aprepitant, Aponvie, Heron Theraps Inc | |||
9561229 | 2035-09-18 | DP | U-2161, U-3440 |
9808465 | 2035-09-18 | U-2161, U-3440 | |
9974742 | 2035-09-18 | DP | |
9974793 | 2035-09-18 | DP | |
9974794 | 2035-09-18 | DP | U-2161, U-3440 |
10500208 | 2035-09-18 | DP | |
10624850 | 2035-09-18 | U-2161, U-3440 | |
10953018 | 2035-09-18 | U-2161, U-3440 | |
11173118 | 2035-09-18 | DP | |
Aprepitant, Emend, Merck | |||
8258132 | 2027-09-26 | DP | U-901, U-1743, U-1916 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Vomiting | D014839 | HP_0002013 | R11.1 | 8 | 25 | 28 | 10 | 15 | 85 |
Nausea | D009325 | HP_0002018 | R11.0 | 2 | 13 | 6 | 6 | 7 | 34 |
Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | 2 | 2 | 3 | 14 | 9 | 29 |
Neoplasms | D009369 | — | C80 | 2 | 2 | 4 | 2 | 4 | 13 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 1 | 4 | 2 | 2 | 11 |
Lymphoma | D008223 | — | C85.9 | — | 1 | — | 2 | 4 | 7 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | 1 | 4 | 6 |
Leukemia | D007938 | — | C95 | — | — | — | 2 | 3 | 5 |
Pruritus | D011537 | HP_0000989 | L29 | — | 2 | — | 1 | 1 | 4 |
Healthy volunteers/patients | — | — | — | 3 | — | — | 1 | — | 4 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 9 | — | — | 9 |
Myeloproliferative disorders | D009196 | — | D47.1 | — | — | 1 | — | 3 | 4 |
Multiple myeloma | D009101 | — | C90.0 | 2 | 2 | 1 | — | — | 4 |
Non-small-cell lung carcinoma | D002289 | — | — | — | 2 | 1 | — | 1 | 4 |
Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | 1 | — | — | 3 |
Colorectal neoplasms | D015179 | — | — | — | 1 | 1 | — | 1 | 3 |
Nasopharyngeal neoplasms | D009303 | — | — | 1 | — | 1 | — | — | 2 |
Gastrointestinal neoplasms | D005770 | — | C26.9 | — | — | 1 | — | 1 | 2 |
Female genital neoplasms | D005833 | — | — | — | — | 1 | — | — | 1 |
Germ cell and embryonal neoplasms | D009373 | — | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myelodysplastic syndromes | D009190 | — | D46 | — | 1 | — | — | 3 | 4 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 2 | — | — | 1 | 4 |
Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 3 | — | — | — | 3 |
Marijuana abuse | D002189 | EFO_0007191 | F12 | 1 | 2 | — | — | — | 3 |
Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 1 | — | — | 1 | 3 |
Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | — | 2 |
Hypertension | D006973 | EFO_0000537 | I10 | — | 1 | — | — | 1 | 2 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | 1 | 2 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 2 | — | — | — | 2 |
Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hiv infections | D015658 | EFO_0000764 | B20 | 3 | — | — | — | — | 3 |
Opioid-related disorders | D009293 | EFO_0005611 | F11 | 2 | — | — | — | — | 2 |
Nasopharyngeal carcinoma | D000077274 | — | — | 1 | — | — | — | — | 1 |
Traumatic brain injuries | D000070642 | — | S06 | 1 | — | — | — | — | 1 |
Tobacco use disorder | D014029 | — | F17 | 1 | — | — | — | — | 1 |
Heroin dependence | D006556 | EFO_0004240 | — | 1 | — | — | — | — | 1 |
Substance-related disorders | D019966 | EFO_0003890 | F13 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Plasma cell neoplasms | D054219 | — | — | — | — | — | — | 3 | 3 |
Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
Neuroblastoma | D009447 | EFO_0000621 | — | — | — | — | — | 2 | 2 |
Trophoblastic neoplasms | D014328 | — | — | — | — | — | — | 2 | 2 |
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | — | — | — | 1 | 1 |
Genetic polymorphism | D011110 | — | — | — | — | — | — | 1 | 1 |
Thromboembolism | D013923 | HP_0001907 | — | — | — | — | — | 1 | 1 |
Brenner tumor | D001948 | — | — | — | — | — | — | 1 | 1 |
Endometrioid carcinoma | D018269 | — | — | — | — | — | — | 1 | 1 |
Fallopian tube neoplasms | D005185 | — | — | — | — | — | — | 1 | 1 |
Drug common name | Aprepitant |
INN | aprepitant |
Description | Aprepitant is a morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. It has a role as an antidepressant, an antiemetic, a peripheral nervous system drug, a neurokinin-1 receptor antagonist and a substance P receptor antagonist. It is a member of triazoles, a member of morpholines, a cyclic acetal and a member of (trifluoromethyl)benzenes. |
Classification | Small molecule |
Drug class | tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
PDB | — |
CAS-ID | 170729-80-3 |
RxCUI | — |
ChEMBL ID | CHEMBL1471 |
ChEBI ID | 499361 |
PubChem CID | 135413536 |
DrugBank | DB00673 |
UNII ID | 1NF15YR6UY (ChemIDplus, GSRS) |