Emend(aprepitant)
Aponvie, Aprepitant, Cinvanti, Emend (aprepitant) is a small molecule pharmaceutical. Aprepitant was first approved as Emend on 2003-03-26. It has been approved in Europe to treat neoplasms, postoperative nausea and vomiting, and vomiting. The pharmaceutical is active against substance-P receptor.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| neoplasms | D009369 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Aponvie, Aprepitant, Cinvanti, Emend (discontinued: Emend)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aprepitant
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| APONVIE | Heron Therapeutics | N-216457 RX | 2022-09-16 | 1 products, RLD, RS |
| CINVANTI | Heron Therapeutics | N-209296 RX | 2017-11-09 | 1 products, RLD, RS |
| EMEND | Merck & Co | N-021549 RX | 2003-03-26 | 2 products, RLD, RS |
| EMEND | Merck & Co | N-207865 RX | 2015-12-17 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aponvie | New Drug Application | 2024-03-13 |
| aprepitant | ANDA | 2024-09-09 |
| aprepitant aprepitant | ANDA | 2025-06-13 |
| cinvanti | New Drug Application | 2024-03-13 |
| emend | New Drug Application | 2024-07-05 |
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Aprepitant, Aponvie, Heron Theraps Inc | |||
| 9561229 | 2035-09-18 | DP | U-2161, U-3440 |
| 9808465 | 2035-09-18 | U-2161, U-3440 | |
| 9974742 | 2035-09-18 | DP | |
| 9974793 | 2035-09-18 | DP | |
| 9974794 | 2035-09-18 | DP | U-2161, U-3440 |
| 10500208 | 2035-09-18 | DP | |
| 10624850 | 2035-09-18 | U-2161, U-3440 | |
| 10953018 | 2035-09-18 | U-2161, U-3440 | |
| 11173118 | 2035-09-18 | DP | |
| Aprepitant, Emend, Merck | |||
| 8258132 | 2027-09-26 | DP | U-901, U-1743, U-1916 |
Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vomiting | D014839 | — | R11.1 | 5 | 11 | 11 | 11 | 5 | 43 |
| Nausea | D009325 | — | R11.0 | 1 | 10 | 9 | 10 | 5 | 35 |
| Postoperative nausea and vomiting | D020250 | EFO_0004888 | — | 2 | 2 | 3 | 3 | 2 | 12 |
| Lymphoma | D008223 | — | C85.9 | — | — | — | 1 | 2 | 3 |
| Neoplasms | D009369 | — | C80 | 1 | — | — | 2 | — | 3 |
| Leukemia | D007938 | — | C95 | — | 2 | — | 1 | — | 3 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | — | 1 | 2 | — | 3 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | 1 | — | 2 |
| Uterine neoplasms | D014594 | EFO_0003859 | C55 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | — | — | 9 | — | — | 9 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | — | 9 | — | — | 9 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | — | — | 9 | — | — | 9 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | — | 1 | — | — | 2 |
| Germ cell and embryonal neoplasms | D009373 | — | — | — | — | 1 | — | — | 1 |
| Plasma cell neoplasms | D054219 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 2 | — | — | — | 2 |
| Myeloid leukemia | D007951 | — | C92 | — | 2 | — | — | — | 2 |
| Lung neoplasms | D008175 | — | C34.90 | — | 1 | — | — | — | 1 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 1 | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | — | 1 | — | — | — | 1 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | — | — | — | 1 |
| Melanoma | D008545 | — | — | — | 1 | — | — | — | 1 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | 1 | — | — | — | 1 |
| Cholangiocarcinoma | D018281 | — | C22.1 | — | 1 | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | — | 1 |
Show 5 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | — | — | — | 1 | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 1 | 1 |
| Sarcoma | D012509 | — | — | — | — | — | — | 1 | 1 |
| Narcotic-related disorders | D000079524 | — | — | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aprepitant |
| INN | aprepitant |
| Description | Aprepitant is a morpholine-based antiemetic, which is or the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. It has a role as an antidepressant, an antiemetic, a peripheral nervous system drug, a neurokinin-1 receptor antagonist and a substance P receptor antagonist. It is a member of triazoles, a member of morpholines, a cyclic acetal and a member of (trifluoromethyl)benzenes. |
| Classification | Small molecule |
| Drug class | tachykinin (neurokinin) receptor antagonists: NK1 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | C[C@@H](O[C@H]1OCCN(Cc2n[nH]c(=O)[nH]2)[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 |
Identifiers
| PDB | — |
| CAS-ID | 170729-80-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1471 |
| ChEBI ID | 499361 |
| PubChem CID | 135413536 |
| DrugBank | DB00673 |
| UNII ID | 1NF15YR6UY (ChemIDplus, GSRS) |
Target
Agency Approved
TACR1
TACR1
Organism
Homo sapiens
Gene name
TACR1
Gene synonyms
NK1R, TAC1R
NCBI Gene ID
Protein name
substance-P receptor
Protein synonyms
neurokinin receptor 1, NK-1 receptor, NK-1R, Tachykinin receptor 1, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
Uniprot ID
Mouse ortholog
Tacr1 (21336)
substance-P receptor (Q8BYR7)
Alternate
No data
Variants
No data
Financial
Revenue by drug
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Cinvanti – Heron Therapeutics /de/
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Emend – Merck & Co
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Aponvie – Heron Therapeutics /de/
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Estimated US medical usage
Aprepitant
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 6,267 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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9,552 adverse events reported
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