Apokyn, Ixense(apomorphine)
Apokyn, Apomorphine, Ixense, Taluvian, Uprima (apomorphine) is a small molecule pharmaceutical. Apomorphine was first approved as Uprima on 2001-05-28. It is used to treat parkinson disease in the USA. It has been approved in Europe to treat erectile dysfunction. The pharmaceutical is active against D(3) dopamine receptor, D(4) dopamine receptor, and D(2) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 2B, alpha-2B adrenergic receptor, transient receptor potential cation channel subfamily A member 1, D(1A) dopamine receptor, D(1B) dopamine receptor, 5-hydroxytryptamine receptor 2A, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 2C, alpha-2A adrenergic receptor, and alpha-2C adrenergic receptor.
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Patent expiration date
Study first post date
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Apokyn, Apomorphine (discontinued: Apokyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Apomorphine hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| APOKYN | MDD US Operations | N-021264 RX | 2004-04-20 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| apokyn | New Drug Application | 2024-10-10 |
| apomorphine hydrocloride | ANDA | 2022-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| parkinson disease | EFO_0002508 | D010300 | G20 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
APOMORPHINE HYDROCHLORIDE, KYNMOBI, SUNOVION PHARMS INC | |||
| 2023-05-21 | NP | ||
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Apomorphine Hydrochloride, Kynmobi, Sunovion Pharms Inc | |||
| 10449146 | 2036-04-19 | U-2825 | |
| 10959943 | 2036-04-19 | U-2825 | |
| 8414922 | 2031-12-16 | DP | U-2825 |
| 8846074 | 2031-12-16 | DP | U-2825 |
| 11419769 | 2031-12-16 | DP | U-2825 |
| 9044475 | 2030-06-11 | DP | |
| 9283219 | 2030-06-11 | DP | U-2825 |
| 9326981 | 2030-06-11 | U-2825 | |
| 9669019 | 2030-06-11 | DP | U-2825 |
| 9669021 | 2030-06-11 | U-2825 | |
| 10420763 | 2030-06-11 | DP | U-2825 |
| 10821074 | 2029-08-07 | DP | |
| 8603514 | 2024-04-03 | DP | |
| 8765167 | 2024-02-20 | DP | |
| 8663687 | 2023-02-02 | DP | |
HCPCS
Code | Description |
|---|---|
| J0364 | Injection, apomorphine hydrochloride, 1 mg |
Clinical
Clinical Trials
60 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 15 | 18 | 6 | 10 | 48 |
| Motor disorders | D000068079 | — | — | — | — | — | 2 | — | 2 |
| Low back pain | D017116 | HP_0003419 | M54.5 | — | — | — | 1 | — | 1 |
| Sleep wake disorders | D012893 | — | G47 | — | — | — | 1 | — | 1 |
| Parasomnias | D020447 | — | G47.5 | — | — | — | 1 | — | 1 |
| Vomiting | D014839 | HP_0002013 | R11.1 | — | — | — | 1 | — | 1 |
| Nausea | D009325 | HP_0002018 | R11.0 | — | — | — | 1 | — | 1 |
| Restless legs syndrome | D012148 | EFO_0004270 | G25.81 | — | — | — | 1 | — | 1 |
| Psychomotor agitation | D011595 | — | — | — | — | — | 1 | — | 1 |
| Syndrome | D013577 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Consciousness disorders | D003244 | — | — | — | 2 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hallucinations | D006212 | HP_0000738 | F06.0 | — | 1 | — | — | — | 1 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | — | 1 |
| Traumatic brain injuries | D000070642 | — | S06 | — | 1 | — | — | — | 1 |
| Brain injuries | D001930 | — | S06.9 | — | 1 | — | — | — | 1 |
| Persistent vegetative state | D018458 | — | R40.3 | — | 1 | — | — | — | 1 |
| Parkinsonian disorders | D020734 | HP_0001300 | G20.C | — | 1 | — | — | — | 1 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sleepiness | D000077260 | — | R40.0 | — | — | — | — | 1 | 1 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | — | — | — | 1 | 1 |
| Progressive supranuclear palsy | D013494 | EFO_0002512 | G23.1 | — | — | — | — | 1 | 1 |
| Corticobasal degeneration | D000088282 | — | — | — | — | — | — | 1 | 1 |
| Epilepsy | D004827 | EFO_0000474 | G40.9 | — | — | — | — | 1 | 1 |
| Generalized epilepsy | D004829 | — | — | — | — | — | — | 1 | 1 |
| Hyperkinesis | D006948 | HP_0000752 | — | — | — | — | — | 1 | 1 |
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | — | — | — | — | 1 | 1 |
| Essential tremor | D020329 | EFO_0003108 | G25.0 | — | — | — | — | 1 | 1 |
| Cancer pain | D000072716 | — | G89.3 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Apomorphine |
| INN | — |
| Description | Apomorphine is an aporphine alkaloid. It has a role as an alpha-adrenergic drug, a serotonergic drug, an antidyskinesia agent, a dopamine agonist, an antiparkinson drug and an emetic. It derives from a hydride of an aporphine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3 |
Target
Alternate
HTR2B
HTR2B
ADRA2B
ADRA2B
TRPA1
TRPA1
DRD1
DRD1
DRD5
DRD5
HTR2A
HTR2A
HTR1A
HTR1A
HTR2C
HTR2C
ADRA2A
ADRA2A
ADRA2C
ADRA2C
Organism
Homo sapiens
Gene name
HTR2B
Gene synonyms
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 2B
Protein synonyms
5-HT 2B receptor, 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled, 5-hydroxytryptamine 2B receptor, Serotonin receptor 2B
Uniprot ID
Mouse ortholog
Htr2b (15559)
5-hydroxytryptamine receptor 2B (Q9QWS2)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Apokyn – Supernus Pharmaceuticals
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Tabular view
Estimated US medical usage
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,787 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8,247 adverse events reported
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