Eliquis(apixaban)
Apixaban, Eliquis (apixaban) is a small molecule pharmaceutical. Apixaban was first approved as Eliquis on 2011-05-18. It is used to treat pulmonary embolism and venous thrombosis in the USA. It has been approved in Europe to treat arthroplasty, stroke, and venous thromboembolism. The pharmaceutical is active against coagulation factor X.
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Commercial
Therapeutic Areas
Trade Name
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Apixaban, Eliquis (discontinued: Apixaban)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Apixaban
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ELIQUIS SPRINKLE | Bristol Myers Squibb | N-220073 RX | 2025-04-17 | 1 products, RLD, RS |
| ELIQUIS | Bristol Myers Squibb | N-202155 RX | 2012-12-28 | 3 products, RLD, RS |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| venous thrombosis | — | D020246 | I82.40 |
| pulmonary embolism | EFO_0003827 | D011655 | I26 |
Agency Specific
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Clinical
Clinical Trials
447 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 3 | 12 | 17 | 29 | 109 | 169 |
| Thrombosis | D013927 | — | — | 7 | 8 | 23 | 17 | 29 | 82 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 8 | 13 | 10 | 16 | 30 | 74 |
| Thromboembolism | D013923 | — | — | 9 | 12 | 6 | 12 | 33 | 70 |
| Hemorrhage | D006470 | MP_0001914 | R58 | 2 | 3 | 12 | 5 | 23 | 45 |
| Stroke | D020521 | EFO_0000712 | I63.9 | 1 | 2 | 12 | 8 | 22 | 44 |
| Venous thrombosis | D020246 | — | I82.40 | 1 | 4 | 17 | 9 | 12 | 41 |
| Embolism | D004617 | — | — | 3 | 3 | 13 | 3 | 14 | 34 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | 4 | 2 | 12 | 4 | 10 | 31 |
| Ischemic stroke | D000083242 | — | — | 1 | 1 | 5 | 4 | 17 | 27 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | 4 | — | 3 | 7 |
| Cerebral hemorrhage | D002543 | — | — | — | 2 | 4 | — | 1 | 7 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | 5 | 6 |
| Aortic valve stenosis | D001024 | EFO_0000266 | — | — | — | 3 | — | 2 | 5 |
| Wounds and injuries | D014947 | — | T14.8 | — | 1 | 1 | — | 2 | 4 |
| Intracranial thrombosis | D020767 | — | — | — | — | 3 | — | 1 | 4 |
| Patent foramen ovale | D054092 | — | Q21.12 | — | 1 | 2 | — | 1 | 4 |
| Renal insufficiency | D051437 | — | N19 | 1 | — | 1 | — | 1 | 3 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | 1 | 1 | — | 1 | 3 |
| Traumatic intracranial hemorrhage | D020198 | — | — | — | — | 3 | — | — | 3 |
Show 51 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 11 | 3 | — | — | — | 14 |
| Nephrotic syndrome | D009404 | EFO_0004255 | N04 | 3 | 1 | — | — | — | 3 |
| Nephrosis | D009401 | — | — | 3 | 1 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 1 | 1 | — | — | — | 2 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | 1 | 1 | — | — | — | 2 |
| Replacement arthroplasty knee | D019645 | — | — | — | 1 | — | — | 1 | 2 |
| Spinal cord injuries | D013119 | EFO_1001919 | — | — | 1 | — | — | 1 | 2 |
| Female genital neoplasms | D005833 | — | — | — | 1 | — | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | — | 1 | — | — | 1 | 2 |
| Fasting | D005215 | EFO_0002756 | — | 1 | 1 | — | — | — | 2 |
Show 19 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Embolism and thrombosis | D016769 | — | — | 2 | — | — | — | 1 | 3 |
| Coagulation protein disorders | D020147 | — | — | 2 | — | — | — | 1 | 3 |
| Vascular diseases | D014652 | EFO_0004264 | I77 | 1 | — | — | — | 1 | 2 |
| Membranous glomerulonephritis | D015433 | EFO_0004254 | N03.2 | 1 | — | — | — | — | 1 |
| Peritoneal dialysis | D010530 | — | — | 1 | — | — | — | — | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | 1 | — | — | — | — | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | — | — | — | — | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | 1 | — | — | — | — | 1 |
| Proteinuria | D011507 | — | R80 | 1 | — | — | — | — | 1 |
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Show 3 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Postoperative hemorrhage | D019106 | — | — | — | — | — | — | 4 | 4 |
| Heart valve diseases | D006349 | EFO_0009551 | I08 | — | — | — | — | 3 | 3 |
| Postthrombotic syndrome | D054070 | EFO_0007452 | I87.0 | — | — | — | — | 3 | 3 |
| Arterial occlusive diseases | D001157 | EFO_0009085 | — | — | — | — | — | 2 | 2 |
| Thrombophilia | D019851 | — | D68.59 | — | — | — | — | 2 | 2 |
| Postoperative complications | D011183 | — | — | — | — | — | — | 2 | 2 |
| Coronary disease | D003327 | — | — | — | — | — | — | 2 | 2 |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 2 | 2 |
| Therapeutic chemoembolization | D016461 | — | — | — | — | — | — | 2 | 2 |
| Postphlebitic syndrome | D011186 | — | I87.0 | — | — | — | — | 2 | 2 |
Show 37 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Apixaban |
| INN | apixaban |
| Description | Apixaban is a pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a pyrazolopyridine, a member of piperidones, a lactam and an aromatic ether. |
| Classification | Small molecule |
| Drug class | antithrombotics, blood coagulation factor XA inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 503612-47-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL231779 |
| ChEBI ID | 72296 |
| PubChem CID | 10182969 |
| DrugBank | DB06605 |
| UNII ID | 3Z9Y7UWC1J (ChemIDplus, GSRS) |
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Eliquis – Bristol Myers Squibb
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Eliquis – Pfizer
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Apixaban
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Trends
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Safety
Black-box Warning
Black-box warning for: Apixaban, Eliquis
Adverse Events
Top Adverse Reactions
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158,504 adverse events reported
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