Eliquis(apixaban)
Apixaban, Eliquis (apixaban) is a small molecule pharmaceutical. Apixaban was first approved as Eliquis on 2011-05-18. It is used to treat pulmonary embolism and venous thrombosis in the USA. It has been approved in Europe to treat arthroplasty, stroke, and venous thromboembolism. The pharmaceutical is active against coagulation factor X.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Apixaban, Eliquis (discontinued: Apixaban)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Apixaban
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ELIQUIS SPRINKLE | Bristol Myers Squibb | N-220073 RX | 2025-04-17 | 1 products, RLD, RS |
| ELIQUIS | Bristol Myers Squibb | N-202155 RX | 2012-12-28 | 3 products, RLD, RS |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| venous thrombosis | — | D020246 | I82.40 |
| pulmonary embolism | EFO_0003827 | D011655 | I26 |
Agency Specific
FDA
EMA
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HCPCS
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Clinical
Clinical Trials
481 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 3 | 7 | 7 | 23 | 39 |
| Thrombosis | D013927 | — | — | 5 | 6 | 10 | 4 | 6 | 29 |
| Thromboembolism | D013923 | — | — | 4 | 4 | — | 4 | 10 | 22 |
| Embolism | D004617 | — | — | — | 3 | 9 | 2 | 5 | 17 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | 3 | 3 | — | 2 | 8 | 16 |
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | 2 | 8 | 1 | 2 | 12 |
| Venous thrombosis | D020246 | — | I82.40 | — | 3 | 9 | 1 | 1 | 12 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 1 | 4 | 1 | 1 | 6 |
| Chronic kidney failure | D007676 | EFO_0003884 | N18.6 | 1 | 1 | 1 | 1 | 1 | 5 |
| Syndrome | D013577 | — | — | — | 2 | 1 | 2 | — | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | 1 | 1 | — | — | 2 |
| Embolic stroke | D000083262 | — | — | — | — | 2 | — | — | 2 |
| Cerebral infarction | D002544 | — | I63 | — | — | 1 | — | — | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | 1 | — | — | 1 |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 1 | — | — | 1 |
| Coronary artery bypass | D001026 | EFO_0003776 | — | — | 1 | 1 | — | — | 1 |
| Leukemia | D007938 | — | C95 | — | — | 1 | — | — | 1 |
| Lymphoma | D008223 | — | C85.9 | — | — | 1 | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | — | 1 | — | — | 1 |
| Lymphoid leukemia | D007945 | — | C91 | — | — | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | — | 2 | — | — | — | 2 |
| Thrombocytopenia | D013921 | HP_0001873 | D69.6 | — | 1 | — | — | — | 1 |
| Patent foramen ovale | D054092 | — | Q21.12 | — | 1 | — | — | — | 1 |
| Paradoxical embolism | D019320 | EFO_1001308 | — | — | 1 | — | — | — | 1 |
| Female genital neoplasms | D005833 | — | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 5 | — | — | — | — | 5 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Crush injuries | D000071576 | — | T14.8 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal insufficiency | D051437 | — | N19 | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Apixaban |
| INN | apixaban |
| Description | Apixaban is a pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases. It has a role as an anticoagulant and an EC 3.4.21.6 (coagulation factor Xa) inhibitor. It is a pyrazolopyridine, a member of piperidones, a lactam and an aromatic ether. |
| Classification | Small molecule |
| Drug class | antithrombotics, blood coagulation factor XA inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(-n2nc(C(N)=O)c3c2C(=O)N(c2ccc(N4CCCCC4=O)cc2)CC3)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 503612-47-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL231779 |
| ChEBI ID | 72296 |
| PubChem CID | 10182969 |
| DrugBank | DB06605 |
| UNII ID | 3Z9Y7UWC1J (ChemIDplus, GSRS) |
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Eliquis – Bristol Myers Squibb
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Eliquis – Pfizer
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Estimated US medical usage
Apixaban
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Trends
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Safety
Black-box Warning
Black-box warning for: Apixaban, Eliquis
Adverse Events
Top Adverse Reactions
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172,121 adverse events reported
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