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Drug ReportsAmpicillin
Ampicillin
Ampicillin, Unasyn (ampicillin) is a small molecule pharmaceutical. Ampicillin was first approved as Polycillin-n on 1982-01-01. It is used to treat actinomycosis, bacillary dysentery, bacterial endocarditis, bacterial infections, and bacterial meningitis amongst others in the USA.
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Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
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1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
digestive system diseasesD004066
respiratory tract diseasesD012140
nervous system diseasesD009422
urogenital diseasesD000091642
cardiovascular diseasesD002318
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
wounds and injuriesD014947
Trade Name
FDA
EMA
Ampicillin (discontinued: Ampicillin, Omnipen-n, Penbritin-s, Polycillin-n, Totacillin-n)
Combinations
Ampicillin sulbactam, Ampicillin trihydrate, Unasyn (discontinued: Amcill, Ampicillin sulbactam, Ampicillin trihydrate, Omnipen (ampicillin), Penbritin, Pfizerpen-a, Polycillin, Polycillin-prb, Principen, Principen w/ probenecid, Probampacin, Totacillin, Unasyn)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Ampicillin
+
Ampicillin trihydrate
Tradename
Company
Number
Date
Products
PRINCIPEN '250'Bristol Myers SquibbN-050056 DISCN1982-01-01
1 products, RLD
PRINCIPEN '500'Bristol Myers SquibbN-050056 DISCN1982-01-01
1 products, RLD
POLYCILLINBristol Myers SquibbN-050093 DISCN1982-01-01
1 products
POLYCILLINBristol Myers SquibbN-050308 DISCN1982-01-01
4 products
POLYCILLINBristol Myers SquibbN-050310 DISCN1982-01-01
2 products
PENBRITINWyethN-050019 DISCN1982-01-01
3 products
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Ampicillin sodium
Tradename
Company
Number
Date
Products
POLYCILLIN-NBristol Myers SquibbN-050309 DISCN1982-01-01
5 products
PENBRITIN-SWyethN-050072 DISCN1982-01-01
6 products, RLD
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Ampicillin sodium
+
Sulbactam sodium
Tradename
Company
Number
Date
Products
UNASYNPfizerN-050608 RX1986-12-31
3 products, RLD, RS
Show 1 discontinued
Ampicillin
+
Ampicillin trihydrate
+
Probenecid
Tradename
Company
Number
Date
Products
PRINCIPEN W/ PROBENECIDBristol Myers SquibbN-050488 DISCN1982-01-01
1 products
POLYCILLIN-PRBBristol Myers SquibbN-050457 DISCN1982-01-01
1 products
Hide discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
ampicillinANDA2026-05-12
ampicillin ampicillin sodiumANDA2025-07-31
ampicillin and sulbactamANDA2026-06-10
ampicillin sodiumANDA2025-10-02
ampicillin sodium and sulbactam sodiumANDA2025-11-28
unasynNew Drug Application2025-05-14
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
respiratory tract infections—D012141J06.9
urinary tract infectionsEFO_0003103D014552N39.0
pneumococcal infectionsEFO_0000772D011008J13
infectious pregnancy complications—D011251—
bacterial infections—D001424A49
gonorrheaDOID_7551D006069A54
bacterial skin diseases—D017192—
escherichia coli infectionsEFO_1001318D004927B96.20
soft tissue infections—D018461—
bacillary dysentery—D004405A03
Show 16 more
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
— J01: Antibacterials for systemic use
— J01C: Beta-lactam antibacterials, penicillins
— J01CA: Penicillins with extended spectrum
— J01CA01: Ampicillin
— J01CA51: Ampicillin, combinations
— J01CR: Combinations of penicillins, incl. beta-lactamase inhibitors
— J01CR01: Ampicillin and beta-lactamase inhibitor
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AA: Antibiotics, ophthalmologic
— S01AA19: Ampicillin
HCPCS
Code
Description
J0290
Injection, ampicillin sodium, 500 mg
J0295
Injection, ampicillin sodium/sulbactam sodium, per 1.5 gm
Clinical
Clinical Trials
962 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PneumoniaD011014EFO_0003106J18—11125
TonsillitisD014069————11—2
SinusitisD012852EFO_0007486J32———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Bacterial pneumoniaD018410EFO_1001272J15.9—11——2
Chronic bronchitisD029481—J42——1——1
BronchitisD001991—J40——1——1
Acute diseaseD000208————1——1
Otitis mediaD010033EFO_0004992H66.9——1——1
OtitisD010031————1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SepsisD018805EFO_0001420A41.9—1———1
ToxemiaD014115———1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients———1————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Community-acquired pneumoniaD000098968——————11
AbscessD000038EFO_0003030—————11
PeritonitisD010538EFO_0008588K65————11
Lung abscessD008169EFO_1001362J85.2————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAmpicillin
INNampicillin
Description
Ampicillin is a penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-phenylacetamido group. It has a role as an antibacterial drug. It is a penicillin, a penicillin allergen and a beta-lactam antibiotic. It is a conjugate acid of an ampicillin(1-).
Classification
Small molecule
Drug classpenicillins
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O
Identifiers
PDB—
CAS-ID69-53-4
RxCUI—
ChEMBL IDCHEMBL174
ChEBI ID28971
PubChem CID6249
DrugBankDB00415
UNII ID7C782967RD (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
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Estimated US medical usage
Ampicillin
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Ampicillin
+
Sulbactam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 233,210 documents
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Safety
Black-box Warning
Black-box warning for: Ampicillin
Adverse Events
Top Adverse Reactions
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6,876 adverse events reported
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