Amorolfine
Amorolfine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Brand Name | Status | Last Update |
|---|---|---|
| amorophen hydrochloride liniment | C200263 | 2024-10-31 |
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Drug
General
| Drug common name | Amorolfine |
| INN | amorolfine |
| Description | Amorolfine is a member of the class of morpholines that is cis-2,6-dimethylmorpholine in which the hydrogen attached to the nitrogen is replaced by a racemic 2-methyl-3-[p-(2-methylbutan-2-yl)phenyl]propyl group. An inhibitor of the action of squalene monooxygenase, Delta(14) reductase and D7-D8 isomerase and an antifungal agent, it is used (generally as its hydrochloride salt) for the topical treatment of fungal nail and skin infections. It has a role as an EC 1.14.13.132 (squalene monooxygenase) inhibitor, an EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor and an EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor. It is a tertiary amino compound and a morpholine antifungal drug. It is a conjugate acid of an amorolfine(1+). |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCC(C)(C)c1ccc(CC(C)CN2C[C@H](C)O[C@H](C)C2)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 78613-35-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL489411 |
| ChEBI ID | 599440 |
| PubChem CID | 54260 |
| DrugBank | — |
| UNII ID | AB0BHP2FH0 (ChemIDplus, GSRS) |
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Safety
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No Black-box warning
Adverse Events
0 adverse events reported
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