Therapeutic Area | MeSH |
---|---|
cardiovascular diseases | D002318 |
signs and symptoms pathological conditions | D013568 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
NORLIQVA | CMP Pharma | N-214439 RX | 2022-02-24 | 1 products, RLD, RS |
NORVASC | Viatris | N-019787 RX | 1992-07-31 | 3 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CADUET | Pharmacia & Upjohn | N-021540 RX | 2004-01-30 | 11 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
CONSENSI | Purple Biotech | N-210045 DISCN | 2018-05-31 | 3 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TRIBENZOR | Cosette Pharmaceuticals | N-200175 RX | 2010-07-23 | 5 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
AZOR | Cosette Pharmaceuticals | N-022100 RX | 2007-09-26 | 4 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
PRESTALIA | Adhera Therapeutics | N-205003 RX | 2015-01-21 | 3 products, RLD, RS |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
TWYNSTA | Boehringer Ingelheim | N-022401 DISCN | 2009-10-16 | 4 products, RLD |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
AMVAZ | Dr Reddys Laboratories | N-021435 DISCN | 2003-10-31 | 3 products |
Brand Name | Status | Last Update |
---|---|---|
amlobenz | ANDA | 2010-04-09 |
amlodipine | ANDA | 2022-01-28 |
amlodipine and atorvastatin | NDA authorized generic | 2023-10-31 |
amlodipine and benazepril hydrochloride | ANDA | 2024-01-08 |
amlodipine and benazepril hydrochloride amlodipine besylate | ANDA | 2021-08-10 |
amlodipine and olmesartan medoxomil | ANDA | 2023-08-21 |
amlodipine and valsartan | ANDA | 2023-12-14 |
amlodipine besylate | ANDA | 2024-02-13 |
amlodipine besylate and olmesartran medoxomil | ANDA | 2023-01-23 |
amlodipine besylate and atorvastatin calcium | NDA authorized generic | 2023-10-31 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
coronary artery disease | — | D003324 | I25.1 |
hypertension | EFO_0000537 | D006973 | I10 |
variant angina pectoris | — | D000788 | I20.1 |
Patent | Expires | Flag | FDA Information |
---|---|---|---|
Amlodipine Besylate, Norliqva, Cmp Dev Llc | |||
11253474 | 2041-02-24 | DP | U-3309, U-3310, U-3311 |
11458095 | 2041-02-24 | DP | U-3309, U-3310, U-3311 |
11723866 | 2041-02-24 | DP | U-3309, U-3310, U-3311 |
Amlodipine Benzoate, Katerzia, Azurity | |||
10799453 | 2039-04-11 | DP | |
10695329 | 2037-10-16 | DP | |
10894039 | 2037-10-06 | U-3, U-185 | |
10952998 | 2037-10-06 | DP | |
10959991 | 2037-10-06 | U-39, U-158 | |
11364230 | 2037-10-06 | DP | |
11471409 | 2037-10-06 | U-3447, U-3448 | |
11484498 | 2037-10-06 | DP | |
11701326 | 2037-10-06 | DP | |
Amlodipine Besylate / Celecoxib, Consensi, Purple Biotech | |||
10350171 | 2038-06-14 | DP | |
10925835 | 2038-06-14 | U-2410 | |
10945960 | 2038-06-14 | DP | |
9408837 | 2030-02-28 | U-2410 | |
9662315 | 2029-05-22 | DP | U-2410 |
Aliskiren Hemifumarate / Amlodipine Besylate, Tekamlo, Novartis | |||
8613949 | 2029-12-21 | DP | |
Amlodipine Besylate / Perindopril Arginine, Prestalia, Adhera | |||
7846961 | 2029-10-05 | DS, DP | U-3 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypertension | D006973 | EFO_0000537 | I10 | 55 | 32 | 122 | 151 | 49 | 402 |
Essential hypertension | D000075222 | — | I10 | 4 | 12 | 28 | 17 | 8 | 65 |
Hyperlipidemias | D006949 | HP_0003077 | E78.5 | 13 | 1 | 7 | 3 | — | 24 |
Dyslipidemias | D050171 | HP_0003119 | — | 5 | — | 6 | 7 | 1 | 19 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | 2 | 12 | 1 | 16 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | 3 | 5 | 4 | 12 |
Cardiovascular diseases | D002318 | HP_0001626 | — | 1 | 1 | 3 | 3 | 4 | 12 |
Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 1 | 1 | 1 | 7 | 1 | 11 |
Hypercholesterolemia | D006937 | HP_0003124 | — | — | — | 4 | 5 | 1 | 10 |
Blood pressure | D001794 | EFO_0004325 | — | 1 | — | — | 8 | 1 | 10 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cognitive dysfunction | D060825 | HP_0001268 | G31.84 | — | 3 | 3 | — | 2 | 7 |
Cerebral hemorrhage | D002543 | — | — | — | — | 2 | — | 1 | 3 |
Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | 1 | 1 | — | 2 | 3 |
Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | 1 | — | 2 | 3 |
Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 1 | 1 | — | 1 | 3 |
Vascular dementia | D015140 | — | F01 | — | — | 1 | — | 1 | 2 |
Iron overload | D019190 | — | — | — | — | 1 | — | 1 | 2 |
Thalassemia | D013789 | EFO_1001996 | D56 | — | 1 | 2 | — | — | 2 |
Hyperaldosteronism | D006929 | HP_0011736 | E26 | — | 1 | 1 | — | — | 2 |
Erectile dysfunction | D007172 | EFO_0004234 | F52.21 | 1 | — | 1 | — | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Insulin resistance | D007333 | HP_0000855 | E88.819 | — | 1 | — | — | 1 | 2 |
Triple negative breast neoplasms | D064726 | — | — | 1 | 2 | — | — | — | 2 |
Abdominal aortic aneurysm | D017544 | EFO_0004214 | — | — | 1 | — | — | 1 | 2 |
Vascular diseases | D014652 | EFO_0004264 | I77 | — | 1 | — | — | 1 | 2 |
Abdominal obesity | D056128 | HP_0001956 | — | — | 1 | — | — | — | 1 |
Nephrotic syndrome | D009404 | EFO_0004255 | N04 | — | 1 | — | — | — | 1 |
Pancreatitis | D010195 | HP_0001733 | K85 | 1 | 1 | — | — | — | 1 |
Dystonic disorders | D020821 | — | G24 | — | 1 | — | — | — | 1 |
Dementia | D003704 | EFO_0003862 | F03 | — | 1 | — | — | — | 1 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Healthy volunteers/patients | — | — | — | 72 | — | — | — | 2 | 74 |
Fasting | D005215 | EFO_0002756 | — | 2 | — | — | — | — | 2 |
Hiv infections | D015658 | EFO_0000764 | B20 | 1 | — | — | — | 1 | 2 |
Drug interactions | D004347 | — | — | 1 | — | — | — | 1 | 2 |
Pharmacokinetics | D010599 | — | — | 1 | — | — | — | 1 | 2 |
Therapeutic equivalency | D013810 | — | — | 2 | — | — | — | — | 2 |
Hiv | D006678 | — | O98.7 | 1 | — | — | — | — | 1 |
Hepatitis c | D006526 | — | B19.2 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Stable angina | D060050 | — | I20.89 | — | — | — | — | 2 | 2 |
Orthostatic hypotension | D007024 | — | I95.1 | — | — | — | — | 1 | 1 |
Delirium | D003693 | — | R41.0 | — | — | — | — | 1 | 1 |
Renal dialysis | D006435 | EFO_0010690 | Z99.2 | — | — | — | — | 1 | 1 |
Morbid obesity | D009767 | EFO_0001074 | — | — | — | — | — | 1 | 1 |
Infertility | D007246 | HP_0000789 | — | — | — | — | — | 1 | 1 |
Renal insufficiency | D051437 | HP_0000083 | N19 | — | — | — | — | 1 | 1 |
Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | — | — | — | 1 | 1 |
Lung diseases | D008171 | HP_0002088 | J98.4 | — | — | — | — | 1 | 1 |
Hyperlipoproteinemia type ii | D006938 | EFO_0004911 | E78.00 | — | — | — | — | 1 | 1 |
Drug common name | Amlodipine |
INN | amlodipine |
Description | Amlodipine is a fully substituted dialkyl 1,4-dihydropyridine-3,5-dicarboxylate derivative, which is used for the treatment of hypertension, chronic stable angina and confirmed or suspected vasospastic angina. It has a role as an antihypertensive agent, a calcium channel blocker and a vasodilator agent. It is a dihydropyridine, a member of monochlorobenzenes, an ethyl ester, a methyl ester and a primary amino compound. |
Classification | Small molecule |
Drug class | phenylpyridine vasodilators; tricyclic compounds |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl |
PDB | — |
CAS-ID | 88150-42-9 |
RxCUI | — |
ChEMBL ID | CHEMBL1491 |
ChEBI ID | 2668 |
PubChem CID | 2162 |
DrugBank | DB00381 |
UNII ID | 1J444QC288 (ChemIDplus, GSRS) |