Amiodarone
Amiodarone, Nexterone, Pacerone (amiodarone) is a small molecule pharmaceutical. Amiodarone was first approved as Cordarone on 1985-12-24. It is used to treat cardiac arrhythmias, supraventricular tachycardia, and ventricular fibrillation in the USA. It is known to target muscarinic acetylcholine receptor M5, potassium voltage-gated channel subfamily A member 7, and sodium channel protein type 5 subunit alpha.
Download report
Favorite
Events Timeline
Commercial
Clinical
Drug
Target
Variants
Financial
Trends
Safety
Events Timeline
5D
1M
3M
6M
YTD
1Y
2Y
5Y
Max
Events
FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
Mock data
Subscribe for the real data
Subscribe for the real data
Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| cardiovascular diseases | D002318 |
| signs and symptoms pathological conditions | D013568 |
Trade Name
FDA
EMA
Nexterone (generic drugs available since 1998-04-30, discontinued: Cordarone)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| amiodarone hci | ANDA | 2022-12-10 |
| amiodarone hcl | ANDA | 2023-03-02 |
| amiodarone hydrochloride | ANDA | 2024-01-28 |
| nexterone | New Drug Application | 2021-09-07 |
| nexterone (amiodarone hci) | New Drug Application | 2020-02-23 |
| pacerone | ANDA | 2024-02-02 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent | Expires | Flag | FDA Information |
|---|---|---|---|
| Amiodarone Hydrochloride, Nexterone, Baxter Hlthcare | |||
| 7635773 | 2029-03-13 | DP | |
HCPCS
Code | Description |
|---|---|
| J0282 | Injection, amiodarone hydrochloride, 30 mg |
Clinical
Clinical Trials
174 clinical trials
View more details
Mock data
Subscribe for the real data
Subscribe for the real data
Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 7 | 26 | 36 | 34 | 102 |
| Ventricular tachycardia | D017180 | — | I47.2 | — | 1 | 4 | 9 | 7 | 21 |
| Cardiac arrhythmias | D001145 | EFO_0004269 | I49.9 | — | 1 | 4 | 3 | 7 | 15 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 2 | 3 | 3 | 8 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | 2 | 2 | 3 | 1 | 7 |
| Ventricular fibrillation | D014693 | HP_0001663 | I49.01 | — | — | 3 | 1 | 1 | 5 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | 1 | 2 | 1 | 4 |
| Septic shock | D012772 | — | A48.3 | — | — | 1 | 2 | 1 | 4 |
| Coronary artery disease | D003324 | — | I25.1 | 1 | — | 2 | 1 | — | 4 |
| Sepsis | D018805 | HP_0100806 | A41.9 | — | — | 1 | 2 | — | 3 |
Show 11 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | 5 | — | 2 | 7 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 4 | — | 2 | 6 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 1 | 3 | — | 1 | 5 |
| Chagas cardiomyopathy | D002598 | EFO_0005529 | — | — | — | 1 | — | 2 | 3 |
| Sudden death cardiac | D016757 | EFO_0004278 | — | — | — | 2 | — | 1 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | 1 | — | 1 | 2 |
| Ebola hemorrhagic fever | D019142 | EFO_0007243 | A98.4 | — | 1 | 1 | — | — | 1 |
| Catheter ablation | D017115 | — | — | — | — | 1 | — | — | 1 |
| Implantable defibrillators | D017147 | EFO_0010674 | — | — | — | 1 | — | — | 1 |
| Hypertrophic cardiomyopathy | D002312 | EFO_0000538 | I42.1 | — | — | 1 | — | — | 1 |
Show 2 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Out-of-hospital cardiac arrest | D058687 | — | — | — | 1 | — | — | 2 | 3 |
| Supraventricular tachycardia | D013617 | HP_0004755 | I47.1 | — | 1 | — | — | 2 | 3 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | — | 1 | — | — | — | 1 |
| Blood pressure | D001794 | EFO_0004325 | — | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | — | — | — | — | 2 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | — | 2 | 2 |
| Hyperuricemia | D033461 | HP_0002149 | — | — | — | — | — | 2 | 2 |
| Phlebitis | D010689 | EFO_1001395 | I80 | — | — | — | — | 2 | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
| Menorrhagia | D008595 | EFO_0003945 | N92.0 | — | — | — | — | 1 | 1 |
| Hemophilia a | D006467 | EFO_0007267 | D66 | — | — | — | — | 1 | 1 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Down syndrome | D004314 | EFO_0001064 | Q90 | — | — | — | — | 1 | 1 |
| Pneumonia | D011014 | EFO_0003106 | — | — | — | — | — | 1 | 1 |
Show 20 more
Epidemiology
Epidemiological information for investigational and approved indications
View more details
Drug
General
| Drug common name | Amiodarone |
| INN | amiodarone |
| Description | Amiodarone is a member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. It has a role as a cardiovascular drug. It is a member of 1-benzofurans, an organoiodine compound, an aromatic ketone and a tertiary amino compound. |
| Classification | Small molecule |
| Drug class | antiarrhythmics: indicates high iodine content |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCc1oc2ccccc2c1C(=O)c1cc(I)c(OCCN(CC)CC)c(I)c1 |
Identifiers
| PDB | — |
| CAS-ID | 1951-25-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL633 |
| ChEBI ID | 2663 |
| PubChem CID | 2157 |
| DrugBank | DB01118 |
| UNII ID | N3RQ532IUT (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
SCN5A
SCN5A
SIRT3
SIRT3
Organism
Homo sapiens
Gene name
SCN5A
Gene synonyms
NCBI Gene ID
Protein name
sodium channel protein type 5 subunit alpha
Protein synonyms
cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit, hH1, Sodium channel protein cardiac muscle subunit alpha, Sodium channel protein type V subunit alpha, sodium channel, voltage-gated, type V, alpha subunit, Voltage-gated sodium channel subunit alpha Nav1.5
Uniprot ID
Mouse ortholog
Scn5a (20271)
sodium channel protein type 5 subunit alpha (Q9JJV9)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
No data
Estimated US medical usage
Amiodarone
Total medical expenditures per year (USD, in millions)
Mock data
Subscribe for the real data
Subscribe for the real data
Number of persons purchased
Mock data
Subscribe for the real data
Subscribe for the real data
Number of purchases
Mock data
Subscribe for the real data
Subscribe for the real data
Refill frequency
Mock data
Subscribe for the real data
Subscribe for the real data
Price per prescription (USD)
Mock data
Subscribe for the real data
Subscribe for the real data
Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
Subscribe for the real data
Subscribe for the real data
Additional graphs summarizing 27,738 documents
View more details
Safety
Black-box Warning
Black-box warning for: Amiodarone hcl, Pacerone
Adverse Events
Top Adverse Reactions
Mock data
Subscribe for the real data
Subscribe for the real data
29,262 adverse events reported
View more details
© 2020-2023 Collaborative Drug Discovery Inc. (CDD) | Terms of Use