Aminophylline
Aminophylline (aminophylline) is a small molecule pharmaceutical. Aminophylline was first approved as Aminophyllin on 1982-01-01. It is used to treat apnea, asthma, bradycardia, bronchial spasm, and bronchitis amongst others in the USA. The pharmaceutical is active against adenosine receptor A2b and adenosine receptor A2a. In addition, it is known to target adenosine receptor A1 and adenosine receptor A3.
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Commercial
Trade Name
FDA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| aminophylline | ANDA | 2024-02-01 |
Indications
FDA
EMA
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA05: Aminophylline
— R03DA55: Aminophylline, combinations
— R03DB: Xanthines and adrenergics
— R03DB05: Aminophylline and adrenergics
HCPCS
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Clinical
Clinical Trials
46 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acute kidney injury | D058186 | HP_0001919 | N17 | 2 | 3 | 3 | 1 | 2 | 8 |
| Post-dural puncture headache | D051299 | — | — | — | — | 1 | 1 | 3 | 5 |
| Anesthesia | D000758 | — | — | — | 1 | — | 2 | — | 3 |
| Coronary artery disease | D003324 | — | I25.1 | — | — | — | 1 | 1 | 2 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | 1 | 1 | 2 |
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | — | 1 |
| Heart block | D006327 | — | I45.89 | — | — | — | 1 | — | 1 |
| Inferior wall myocardial infarction | D056989 | EFO_1000983 | — | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Asthma | D001249 | EFO_0000270 | J45 | — | — | 1 | — | 2 | 3 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | 1 | — | — | — | 1 |
| Heart arrest | D006323 | EFO_0009492 | I46 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Altitude sickness | D000532 | EFO_1000782 | T70.29 | 2 | — | — | — | — | 2 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | — | 1 |
| Premature obstetric labor | D007752 | — | O60 | 1 | — | — | — | — | 1 |
| Urinary bladder neoplasms | D001749 | — | C67 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cystic fibrosis | D003550 | EFO_0000390 | E84 | — | — | — | — | 4 | 4 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | — | 1 | 1 |
| Cough | D003371 | HP_0012735 | R05 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aminophylline |
| INN | aminophylline |
| Description | Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN |
Identifiers
| PDB | — |
| CAS-ID | 317-34-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1370561 |
| ChEBI ID | — |
| PubChem CID | 9433 |
| DrugBank | DB01223 |
| UNII ID | 27Y3KJK423 (ChemIDplus, GSRS) |
Target
Variants
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Financial
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Estimated US medical usage
Aminophylline
Total medical expenditures per year (USD, in millions)
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Trends
PubMed Central
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Additional graphs summarizing 6,190 documents
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Safety
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Adverse Events
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691 adverse events reported
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