Amifostine
Ethyol (amifostine) is a small molecule pharmaceutical. Amifostine was first approved as Ethyol on 1995-12-08. It is used to treat experimental radiation injuries in the USA.
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Amifostine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ETHYOL | Cosette Pharmaceuticals | N-020221 DISCN | 1995-12-08 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ethyol | New Drug Application | 2023-11-02 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| experimental radiation injuries | — | D011833 | — |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
HCPCS
Code | Description |
|---|---|
| J0207 | Injection, amifostine, 500 mg |
Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Drug-related side effects and adverse reactions | D064420 | — | T88.7 | 7 | 13 | 1 | 1 | — | 19 |
| Head and neck neoplasms | D006258 | — | — | 4 | 13 | 1 | 2 | 1 | 17 |
| Neoplasms | D009369 | — | C80 | 8 | 6 | 1 | 1 | 1 | 16 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 3 | 11 | 1 | 1 | 1 | 15 |
| Lymphoma | D008223 | — | C85.9 | 3 | 4 | — | 1 | — | 7 |
| Mucositis | D052016 | EFO_1001898 | — | — | 3 | — | 1 | — | 4 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 3 | 8 | 1 | — | — | 10 |
| Radiation effects | D011830 | — | — | 3 | 9 | 1 | — | — | 10 |
| Non-small-cell lung carcinoma | D002289 | — | — | — | 4 | 1 | — | — | 5 |
| Multiple myeloma | D009101 | — | C90.0 | 3 | — | 1 | — | — | 4 |
| Plasma cell neoplasms | D054219 | — | — | 3 | — | 1 | — | — | 4 |
| Carcinoma | D002277 | — | C80.0 | 2 | 3 | 1 | — | — | 4 |
| Neurotoxicity syndromes | D020258 | — | G92 | — | 3 | 1 | — | — | 4 |
| Xerostomia | D014987 | — | K11.7 | — | 2 | 1 | — | — | 3 |
| Ovarian epithelial carcinoma | D000077216 | — | — | 1 | 2 | 1 | — | — | 3 |
| Squamous cell carcinoma | D002294 | — | — | 1 | 1 | 1 | — | — | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 2 | 8 | — | — | — | 9 |
| Preleukemia | D011289 | — | — | 2 | 8 | — | — | — | 9 |
| Syndrome | D013577 | — | — | 2 | 8 | — | — | — | 9 |
| Leukemia | D007938 | — | C95 | 6 | 6 | — | — | — | 9 |
| Sarcoma | D012509 | — | — | 2 | 4 | — | — | — | 5 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 4 | — | — | — | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 2 | — | — | — | 3 |
| Myeloid leukemia | D007951 | — | C92 | 2 | 2 | — | — | — | 3 |
| Central nervous system neoplasms | D016543 | — | — | 1 | 2 | — | — | — | 3 |
| Germ cell and embryonal neoplasms | D009373 | — | — | 1 | 2 | — | — | — | 3 |
Show 31 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Plasmacytoma | D010954 | — | C90.3 | 2 | — | — | — | — | 2 |
| Recurrence | D012008 | — | — | 1 | — | — | — | — | 1 |
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 1 | — | — | — | — | 1 |
| Melanoma | D008545 | — | — | 1 | — | — | — | — | 1 |
| Immunoglobulin light-chain amyloidosis | D000075363 | — | — | 1 | — | — | — | — | 1 |
| Amyloidosis | D000686 | EFO_1001875 | E85 | 1 | — | — | — | — | 1 |
| Retinoblastoma | D012175 | — | — | 1 | — | — | — | — | 1 |
| Chordoma | D002817 | EFO_0000334 | — | 1 | — | — | — | — | 1 |
| Fever | D005334 | HP_0001945 | R50.9 | 1 | — | — | — | — | 1 |
| Hyperthermia | D000084462 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Amifostine |
| INN | amifostine |
| Description | Amifostine is an organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. It has a role as a prodrug, a radiation protective agent and an antioxidant. It is a diamine and an organic thiophosphate. It is functionally related to a cysteamine. |
| Classification | Small molecule |
| Drug class | phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCNCCSP(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 20537-88-6 |
| RxCUI | 1545987 |
| ChEMBL ID | CHEMBL1006 |
| ChEBI ID | 2636 |
| PubChem CID | 2141 |
| DrugBank | DB01143 |
| UNII ID | ILA426L95O (ChemIDplus, GSRS) |
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Ethyol – Cumberland Pharmaceuticals
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Additional graphs summarizing 3,508 documents
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Safety
Black-box Warning
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Adverse Events
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845 adverse events reported
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