Amifostine
Ethyol (amifostine) is a small molecule pharmaceutical. Amifostine was first approved as Ethyol on 1995-12-08. It is used to treat experimental radiation injuries in the USA.
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Amifostine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ETHYOL | Cosette Pharmaceuticals | N-020221 DISCN | 1995-12-08 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| ethyol | New Drug Application | 2023-11-02 |
Indications
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Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| experimental radiation injuries | — | D011833 | — |
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HCPCS
Code | Description |
|---|---|
| J0207 | Injection, amifostine, 500 mg |
Clinical
Clinical Trials
84 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | — | — | — | 1 | — | 1 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | 1 | — | 1 |
| Mucositis | D052016 | EFO_1001898 | — | — | — | — | 1 | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Amifostine |
| INN | amifostine |
| Description | Amifostine is an organic thiophosphate that is the S-phospho derivative of 2-[(3-aminopropyl)amino]ethanethiol. A prodrug for the free thiol, WR-1065, which is used as a cytoprotectant in cancer chemotherapy and radiotherapy. It has a role as a prodrug, a radiation protective agent and an antioxidant. It is a diamine and an organic thiophosphate. It is functionally related to a cysteamine. |
| Classification | Small molecule |
| Drug class | phosphoro-derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | NCCCNCCSP(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 20537-88-6 |
| RxCUI | 1545987 |
| ChEMBL ID | CHEMBL1006 |
| ChEBI ID | 2636 |
| PubChem CID | 2141 |
| DrugBank | DB01143 |
| UNII ID | ILA426L95O (ChemIDplus, GSRS) |
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Ethyol – Cumberland Pharmaceuticals
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847 adverse events reported
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