Therapeutic Area | MeSH |
---|---|
respiratory tract diseases | D012140 |
cardiovascular diseases | D002318 |
Tradename | Company | Number | Date | Products |
---|---|---|---|---|
LETAIRIS | Gilead Sciences | N-022081 RX | 2007-06-15 | 2 products, RLD, RS |
Brand Name | Status | Last Update |
---|---|---|
ambrisentan | ANDA | 2024-01-30 |
letairis | New Drug Application | 2020-12-17 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
pulmonary hypertension | EFO_0001361 | D006976 | I27.20 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 4 | 10 | 10 | 5 | 5 | 31 |
Pulmonary arterial hypertension | D000081029 | — | — | 1 | 1 | 7 | 5 | 8 | 21 |
Systemic scleroderma | D012595 | EFO_0000717 | M34 | — | 1 | — | 2 | 2 | 5 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 2 | — | 1 | — | 3 |
Autonomic nervous system diseases | D001342 | EFO_0009532 | G90 | — | — | — | 1 | — | 1 |
Connective tissue diseases | D003240 | EFO_1001986 | M35 | — | — | — | 1 | — | 1 |
Dyspnea | D004417 | HP_0002094 | R06.0 | — | — | — | 1 | — | 1 |
Heart failure | D006333 | HP_0001635 | I50 | — | — | — | 1 | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Covid-19 | D000086382 | — | U07.1 | — | 2 | 1 | — | — | 2 |
Hypertension | D006973 | EFO_0000537 | I10 | — | — | 2 | — | — | 2 |
Altitude sickness | D000532 | EFO_1000782 | T70.29 | 1 | 1 | 1 | — | — | 2 |
Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 1 | 1 | — | 1 | 2 |
Idiopathic pulmonary fibrosis | D054990 | — | J84.112 | — | — | 2 | — | — | 2 |
Vascular diseases | D014652 | EFO_0004264 | I77 | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Acute kidney injury | D058186 | HP_0001919 | N17 | — | 2 | — | — | — | 2 |
Hypoxia | D000860 | HP_0012418 | R09.02 | — | 1 | — | — | — | 1 |
Portal hypertension | D006975 | EFO_0000666 | K76.6 | — | 1 | — | — | — | 1 |
Ascites | D001201 | HP_0001541 | R18 | — | 1 | — | — | — | 1 |
Hypoplastic left heart syndrome | D018636 | — | Q23.4 | — | 1 | — | — | — | 1 |
Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
Hepatorenal syndrome | D006530 | — | K76.7 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | 1 | — | — | — | — | 1 |
Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | — | — | — | — | 1 |
Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Familial primary pulmonary hypertension | D065627 | — | I27.0 | — | — | — | — | 1 | 1 |
Drug interactions | D004347 | — | — | — | — | — | — | 1 | 1 |
Ischemia | D007511 | EFO_0000556 | — | — | — | — | — | 1 | 1 |
Ulcer | D014456 | MPATH_579 | — | — | — | — | — | 1 | 1 |
Drug common name | Ambrisentan |
INN | ambrisentan |
Description | Ambrisentan is a diarylmethane. |
Classification | Small molecule |
Drug class | endothelin receptor antagonists |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | COC(c1ccccc1)(c1ccccc1)[C@H](Oc1nc(C)cc(C)n1)C(=O)O |
PDB | — |
CAS-ID | 177036-94-1 |
RxCUI | — |
ChEMBL ID | CHEMBL1111 |
ChEBI ID | — |
PubChem CID | 6918493 |
DrugBank | DB06403 |
UNII ID | HW6NV07QEC (ChemIDplus, GSRS) |