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AboutPricing
Drug ReportsAlprazolam
Alprazolam
Alprazolam, Xanax (alprazolam) is a small molecule pharmaceutical. Alprazolam was first approved as Xanax on 1982-01-01. It is used to treat agoraphobia, depressive disorder, and panic disorder in the USA. It is known to target gamma-aminobutyric acid receptor subunit alpha-2, gamma-aminobutyric acid receptor subunit alpha-1, gamma-aminobutyric acid receptor subunit alpha-5, and gamma-aminobutyric acid receptor subunit alpha-3.
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Events Timeline
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FDA approval date
EMA approval date
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Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
mental disordersD001523
Trade Name
FDA
EMA
Alprazolam, Xanax (discontinued: Alprazolam, Niravam)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alprazolam
Tradename
Company
Number
Date
Products
XANAXUpjohnN-018276 RX1982-01-01
4 products, RLD, RS
XANAX XRUpjohnN-021434 RX2003-01-17
4 products, RLD, RS
Show 1 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
alprazolamANDA2027-07-31
alprazolam c-ivANDA2025-01-22
alprazolam intensol2006-01-04
alprazolam xrNDA authorized generic2011-04-12
gabazolamineunapproved drug other2011-08-18
gabazolamine-0.5unapproved drug other2011-08-01
niravamNew Drug Application2011-04-19
sentrazolam amunapproved drug other2011-08-01
xanaxNew Drug Application2023-04-12
xanax xrNew Drug Application2010-04-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
panic disorderEFO_0004262D016584F41.0
depressive disorderEFO_1002014D003866F32.A
agoraphobiaEFO_1001872D000379F40.0
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
N: Nervous system drugs
— N05: Psycholeptics
— N05B: Anxiolytics
— N05BA: Benzodiazepine derivative anxiolytics
— N05BA12: Alprazolam
HCPCS
No data
Clinical
Clinical Trials
103 clinical trials
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AnxietyD001007EFO_0005230F41.12————2
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAlprazolam
INNalprazolam
Description
Alprazolam is a member of the class of triazolobenzodiazepines that is 4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine carrying methyl, phenyl and chloro substituents at positions 1, 6 and 8 respectively. Alprazolam is only found in individuals that have taken this drug. It has a role as an anxiolytic drug, an anticonvulsant, a muscle relaxant, a sedative, a GABA agonist and a xenobiotic. It is a triazolobenzodiazepine and an organochlorine compound.
Classification
Small molecule
Drug classBenzodiazepine
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
Cc1nnc2n1-c1ccc(Cl)cc1C(c1ccccc1)=NC2
Identifiers
PDB—
CAS-ID28981-97-7
RxCUI—
ChEMBL IDCHEMBL661
ChEBI ID2611
PubChem CID2118
DrugBankDB00404
UNII IDYU55MQ3IZY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
BRD4
BRD4
Organism
Homo sapiens
Gene name
BRD4
Gene synonyms
HUNK1
NCBI Gene ID
23476
Protein name
bromodomain-containing protein 4
Protein synonyms
chromosome-associated protein, female sterile homeotic related gene 4, mitotic chromosome-associated protein, Protein HUNK1
Uniprot ID
O60885
Mouse ortholog
Brd4 (57261)
bromodomain-containing protein 4 (Q9ESU6)
Variants
No data
Financial
Revenue by drug
$
€
£
â‚£
Xanax – Viatris
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Xanax – Pfizer
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Estimated US medical usage
Alprazolam
Total medical expenditures per year (USD, in millions)
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Number of persons purchased
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Number of purchases
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Refill frequency
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Price per prescription (USD)
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 10,068 documents
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Safety
Black-box Warning
Black-box warning for: Alprazolam, Alprazolam c-iv, Xanax
Adverse Events
Top Adverse Reactions
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65,846 adverse events reported
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