Alovudine
Alovudine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
90 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 2 | — | 1 | 8 | 13 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | 1 | 2 | 1 | — | 3 | 6 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 8 | 4 | — | — | 4 | 15 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 5 | 4 | — | — | 5 | 12 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | — | — | 4 | 9 |
| Melanoma | D008545 | — | — | 2 | 2 | — | — | 1 | 5 |
| Central nervous system neoplasms | D016543 | — | — | 3 | 1 | — | — | 2 | 5 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 2 | — | — | 1 | 4 |
| Lymphoma | D008223 | — | C85.9 | 2 | 2 | — | — | 2 | 4 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | — | — | 3 | 4 |
| Nervous system neoplasms | D009423 | — | — | 2 | 1 | — | — | 1 | 3 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 1 | — | — | 1 | 3 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | — | — | — | — | 2 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 2 | — | — | — | — | 2 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors | D018242 | — | — | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors peripheral | D018241 | — | — | 1 | — | — | — | — | 1 |
| Neuroectodermal tumors | D017599 | — | — | 1 | — | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Verrucous carcinoma | D018289 | — | — | 1 | — | — | — | — | 1 |
| Triple negative breast neoplasms | D064726 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Essential thrombocythemia | D013920 | — | D47.3 | — | — | — | — | 3 | 3 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | — | — | — | 3 | 3 |
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 3 | 3 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 2 | 2 |
| Hodgkin disease | D006689 | — | C81 | — | — | — | — | 2 | 2 |
| Polycythemia vera | D011087 | — | D45 | — | — | — | — | 2 | 2 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | — | — | — | 1 | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | — | — | — | 1 | 1 |
| Pulmonary fibrosis | D011658 | — | J84.10 | — | — | — | — | 1 | 1 |
| Female genital neoplasms | D005833 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Alovudine |
| INN | alovudine |
| Description | Alovudine is a pyrimidine 2',3'-dideoxyribonucleoside. |
| Classification | Small molecule |
| Drug class | antineoplastics; antivirals (zidovudine group) (exception: edoxudine) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O |
Identifiers
| PDB | — |
| CAS-ID | 25526-93-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL105318 |
| ChEBI ID | — |
| PubChem CID | 33039 |
| DrugBank | DB06198 |
| UNII ID | PG53R0DWDQ (ChemIDplus, GSRS) |
Target
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Safety
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