Alovudine
Alovudine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
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Clinical
Clinical Trials
89 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | 3 | — | 1 | 8 | 14 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 9 | 5 | — | — | 6 | 18 |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 4 | 3 | — | — | 6 | 12 |
| Non-small-cell lung carcinoma | D002289 | — | — | 2 | 4 | — | — | 4 | 9 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 2 | 4 | — | — | 4 | 9 |
| Carcinoma | D002277 | — | C80.0 | 4 | 1 | — | — | 1 | 6 |
| Melanoma | D008545 | — | — | 2 | 2 | — | — | 1 | 5 |
| Head and neck neoplasms | D006258 | — | — | 1 | 1 | — | — | 3 | 5 |
| Central nervous system neoplasms | D016543 | — | — | 3 | 1 | — | — | 2 | 5 |
| Nervous system neoplasms | D009423 | — | — | 2 | 1 | — | — | 2 | 4 |
| Sarcoma | D012509 | — | — | 4 | 2 | — | — | — | 4 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Renal cell carcinoma | D002292 | EFO_0000376 | — | 2 | — | — | — | — | 2 |
| Hypoxia | D000860 | HP_0012418 | R09.02 | 1 | — | — | — | — | 1 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors | D018242 | — | — | 1 | — | — | — | — | 1 |
| Primitive neuroectodermal tumors peripheral | D018241 | — | — | 1 | — | — | — | — | 1 |
| Neuroectodermal tumors | D017599 | — | — | 1 | — | — | — | — | 1 |
| Salivary gland neoplasms | D012468 | EFO_0003826 | D11 | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | — | — | — | — | 1 |
| Squamous cell carcinoma | D002294 | — | — | 1 | — | — | — | — | 1 |
| Verrucous carcinoma | D018289 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | — | — | 3 | 3 |
| Myeloproliferative disorders | D009196 | — | D47.1 | — | — | — | — | 2 | 2 |
| Essential thrombocythemia | D013920 | — | D47.3 | — | — | — | — | 2 | 2 |
| Primary myelofibrosis | D055728 | — | D47.4 | — | — | — | — | 2 | 2 |
| Thrombocytosis | D013922 | HP_0001894 | D75.83 | — | — | — | — | 2 | 2 |
| Esophageal neoplasms | D004938 | — | C15 | — | — | — | — | 2 | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | — | — | — | — | 1 | 1 |
| Hodgkin disease | D006689 | — | C81 | — | — | — | — | 1 | 1 |
| Nasopharyngeal carcinoma | D000077274 | — | — | — | — | — | — | 1 | 1 |
| Nasopharyngeal neoplasms | D009303 | — | — | — | — | — | — | 1 | 1 |
Show 13 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Alovudine |
| INN | alovudine |
| Description | Alovudine is a pyrimidine 2',3'-dideoxyribonucleoside. |
| Classification | Small molecule |
| Drug class | antineoplastics; antivirals (zidovudine group) (exception: edoxudine) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O |
Identifiers
| PDB | — |
| CAS-ID | 25526-93-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL105318 |
| ChEBI ID | — |
| PubChem CID | 33039 |
| DrugBank | DB06198 |
| UNII ID | PG53R0DWDQ (ChemIDplus, GSRS) |
Target
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Safety
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