Alosetron
Alosetron, Lotronex (alosetron) is a small molecule pharmaceutical. Alosetron was first approved as Lotronex on 2000-02-09. It is used to treat abdominal pain, diarrhea, and irritable bowel syndrome in the USA.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Alosetron, Lotronex (discontinued: Alosetron)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alosetron hydrochloride
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| LOTRONEX | Sebela Pharmaceuticals | N-021107 RX | 2000-02-09 | 2 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| alosetron | ANDA | 2025-10-01 |
| alosetron hydrochloride | ANDA | 2025-09-09 |
| lotronex | New Drug Application | 2019-05-03 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| irritable bowel syndrome | EFO_0000555 | D043183 | K58 |
| diarrhea | — | D003967 | R19.7 |
| abdominal pain | EFO_0003766 | D015746 | R10.9 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
5 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | 1 | 2 | 1 | 1 | 5 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Alosetron |
| INN | alosetron |
| Description | Alosetron is a pyrido[4,3-b]indole compound having a 5-methyl-1H-imidazol-4-ylmethyl group at the 2-position. It has a role as a serotonergic antagonist, an antiemetic and a gastrointestinal drug. It is a pyridoindole and a member of imidazoles. |
| Classification | Small molecule |
| Drug class | serotonin 5-HT3 receptor antagonists |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O |
Identifiers
| PDB | — |
| CAS-ID | 122852-42-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1110 |
| ChEBI ID | 253342 |
| PubChem CID | 2099 |
| DrugBank | DB00969 |
| UNII ID | 13Z9HTH115 (ChemIDplus, GSRS) |
Target
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Financial
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Estimated US medical usage
Alosetron
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,088 documents
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Safety
Black-box Warning
Black-box warning for: Alosetron, Alosetron hydrochloride, Lotronex
Adverse Events
Top Adverse Reactions
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818 adverse events reported
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