Almotriptan
Almotriptan (almotriptan) is a small molecule pharmaceutical. Almotriptan was first approved as Axert on 2001-05-07. It is used to treat migraine disorders in the USA. It is known to target 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine receptor 1D.
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Commercial
Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| nervous system diseases | D009422 |
Trade Name
FDA
EMA
Almotriptan (discontinued: Axert)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Almotriptan malate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| AXERT | Johnson & Johnson | N-021001 DISCN | 2001-05-07 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| almotriptan | ANDA | 2025-04-02 |
| almotriptan malate | ANDA | 2017-06-15 |
| axert | New Drug Application | 2012-10-10 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| migraine disorders | EFO_0003821 | D008881 | G43 |
Agency Specific
FDA
EMA
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Patent Expiration
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HCPCS
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Clinical
Clinical Trials
16 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | 2 | 4 | — | 6 |
| Headache | D006261 | — | R51 | — | — | — | 2 | — | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | 1 | — | 1 |
| Secondary headache disorders | D051271 | — | — | — | — | — | 1 | — | 1 |
| Prescription drug overuse | D000067490 | — | — | — | — | — | 1 | — | 1 |
| Migraine without aura | D020326 | EFO_0005296 | G43.0 | — | — | — | 1 | — | 1 |
| Migraine with aura | D020325 | EFO_0005295 | G43.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Almotriptan |
| INN | almotriptan |
| Description | Almotriptan is an indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position. It has a role as a non-steroidal anti-inflammatory drug, a serotonergic agonist and a vasoconstrictor agent. It is a member of indoles, a sulfonamide and a tertiary amine. |
| Classification | Small molecule |
| Drug class | antimigraine agents (5-HT1 receptor agonists); sumatriptan derivatives |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12 |
Identifiers
| PDB | — |
| CAS-ID | 154323-57-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1505 |
| ChEBI ID | 520985 |
| PubChem CID | 123606 |
| DrugBank | DB00918 |
| UNII ID | 1O4XL5SN61 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HTR1B
HTR1B
HTR1D
HTR1D
Organism
Homo sapiens
Gene name
HTR1B
Gene synonyms
HTR1DB
NCBI Gene ID
Protein name
5-hydroxytryptamine receptor 1B
Protein synonyms
5-HT-1D-beta, 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled, S12, Serotonin 1D beta receptor, Serotonin receptor 1B
Uniprot ID
Mouse ortholog
Htr1b (15551)
5-hydroxytryptamine receptor 1B (P28334)
Variants
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Financial
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Estimated US medical usage
Almotriptan
Total medical expenditures per year (USD, in millions)
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 663 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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859 adverse events reported
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