Lopurin, Duzallo(allopurinol)
Allopurinol, Aloprim, Duzallo, Lopurin, Zyloprim (allopurinol) is a small molecule pharmaceutical. Allopurinol was first approved as Lopurin on 1982-01-01. It is used to treat gout in the USA. It has been approved in Europe to treat gout. The pharmaceutical is active against xanthine dehydrogenase/oxidase.
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Commercial
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Trade Name
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Allopurinol, Aloprim, Lopurin, Zyloprim (discontinued: Allopurinol, Lopurin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol sodium
Allopurinol
Allopurinol
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Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUZALLO | Ironwood Pharmaceuticals | N-209203 DISCN | 2017-08-18 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| allopurinol | ANDA | 2024-11-06 |
| allopurinol sodium | ANDA | 2022-03-01 |
| aloprim | New Drug Application | 2022-02-18 |
| zyloprim | New Drug Application | 2023-09-25 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| gout | EFO_0004274 | D006073 | M10 |
| hyperuricemia | HP_0002149 | D033461 | — |
Agency Specific
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Clinical
Clinical Trials
215 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 3 | 20 | 20 | 12 | 12 | 64 |
| Hyperuricemia | D033461 | HP_0002149 | — | 2 | 15 | 6 | 5 | 5 | 31 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 4 | 4 | 1 | 5 | 7 | 21 |
| Syndrome | D013577 | — | — | 2 | 10 | 2 | 2 | 1 | 16 |
| Chronic renal insufficiency | D051436 | — | N18 | 4 | 3 | — | 2 | 4 | 13 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | 4 | 2 | 3 | 1 | 1 | 10 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 6 | 1 | 3 | — | 9 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 7 | 2 | 1 | — | 9 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | 1 | 3 | 2 | 1 | 6 |
| Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | 1 | 2 | 1 | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 6 | 17 | 2 | — | 1 | 23 |
| Lymphoma | D008223 | — | C85.9 | 5 | 12 | 2 | — | 1 | 18 |
| Lymphoid leukemia | D007945 | — | C91 | 4 | 11 | 2 | — | — | 15 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | — | 3 | 8 | 2 | — | 1 | 13 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 1 | 2 | 2 | — | 1 | 6 |
| Neoplasms | D009369 | — | C80 | 1 | 4 | 1 | — | — | 6 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | 2 | — | 1 | 4 |
| Tumor lysis syndrome | D015275 | — | E88.3 | — | 1 | 2 | — | — | 3 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | 3 | 3 | — | — | 3 |
| Fibrosis | D005355 | — | — | — | 3 | 3 | — | — | 3 |
Show 29 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 7 | — | — | 1 | 10 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 1 | 7 | — | — | — | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 5 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | 5 | — | — | — | 6 |
| Preleukemia | D011289 | — | — | 2 | 5 | — | — | — | 6 |
| Myeloid leukemia acute | D015470 | — | C92.0 | — | 5 | — | — | 1 | 6 |
| Burkitt lymphoma | D002051 | — | C83.7 | — | 5 | — | — | — | 5 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | — | 5 | — | — | — | 5 |
| Plasmacytoma | D010954 | — | C90.3 | 2 | 2 | — | — | — | 4 |
Show 46 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | HP_0012393 | T78.40 | 1 | — | — | — | — | 1 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Fasting | D005215 | EFO_0002756 | — | 1 | — | — | — | — | 1 |
| Vasodilation | D014664 | — | — | 1 | — | — | — | — | 1 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | 1 | — | — | — | — | 1 |
| Inflammatory bowel diseases | D015212 | EFO_0003767 | — | 1 | — | — | — | — | 1 |
| Intestinal diseases | D007410 | HP_0002242 | K63.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Rheumatic diseases | D012216 | — | M79.0 | — | — | — | — | 1 | 1 |
| Rheumatic fever | D012213 | EFO_1001160 | I00-I02 | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | HP_0000855 | — | — | — | — | — | 1 | 1 |
| Liver transplantation | D016031 | EFO_0010682 | — | — | — | — | — | 1 | 1 |
| Pathologic constriction | D003251 | — | — | — | — | — | — | 1 | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 1 | 1 |
| Eisenmenger complex | D004541 | — | I27.83 | — | — | — | — | 1 | 1 |
| Stevens-johnson syndrome | D013262 | EFO_0004276 | L51.1 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | HP_0001733 | K85 | — | — | — | — | 1 | 1 |
| Endoscopic retrograde cholangiopancreatography | D002760 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Allopurinol |
| INN | allopurinol |
| Description | Allopurinol is a bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. It has a role as a radical scavenger, a gout suppressant, an antimetabolite and an EC 1.17.3.2 (xanthine oxidase) inhibitor. It is an organic heterobicyclic compound and a nucleobase analogue. It derives from a hydride of a 1H-pyrazolo[4,3-d]pyrimidine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1ncnc2[nH]ncc12 |
Identifiers
| PDB | — |
| CAS-ID | 315-30-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1467 |
| ChEBI ID | 40279 |
| PubChem CID | 135401907 |
| DrugBank | DB00437 |
| UNII ID | 63CZ7GJN5I (ChemIDplus, GSRS) |
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Allopurinol
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Safety
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23,479 adverse events reported
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