Lopurin, Duzallo(allopurinol)
Allopurinol, Aloprim, Duzallo, Lopurin, Zyloprim (allopurinol) is a small molecule pharmaceutical. Allopurinol was first approved as Lopurin on 1982-01-01. It is used to treat gout in the USA. It has been approved in Europe to treat gout. The pharmaceutical is active against xanthine dehydrogenase/oxidase.
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Commercial
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Trade Name
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Allopurinol, Aloprim, Lopurin, Zyloprim (discontinued: Allopurinol, Lopurin)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol sodium
Allopurinol
Allopurinol
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Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUZALLO | Ironwood Pharmaceuticals | N-209203 DISCN | 2017-08-18 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| allopurinol | ANDA | 2025-11-26 |
| allopurinol sodium | ANDA | 2022-03-01 |
| aloprim | New Drug Application | 2022-02-18 |
| zyloprim | ANDA | 2018-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| gout | EFO_0004274 | D006073 | M10 |
| hyperuricemia | — | D033461 | — |
Agency Specific
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Clinical
Clinical Trials
220 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Gout | D006073 | EFO_0004274 | M10 | 3 | 20 | 21 | 13 | 12 | 66 |
| Hyperuricemia | D033461 | — | — | 2 | 16 | 8 | 7 | 5 | 36 |
| Chronic renal insufficiency | D051436 | — | N18 | 3 | 3 | — | 2 | 4 | 12 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 2 | 1 | 1 | 1 | 7 | 12 |
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | 4 | 1 | 3 | 2 | 1 | 10 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | 6 | 1 | 3 | — | 9 |
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | 6 | 2 | 1 | — | 8 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | — | 1 | 4 | 1 | 1 | 6 |
| Nephrolithiasis | D053040 | — | N20.0 | — | 1 | 1 | 3 | — | 5 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | 1 | — | 4 | — | 5 |
Show 32 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 5 | 16 | 1 | — | 1 | 21 |
| Lymphoma | D008223 | — | C85.9 | 6 | 13 | 1 | — | 1 | 18 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 5 | 9 | 2 | — | 1 | 15 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 4 | 4 | 2 | — | 1 | 9 |
| Syndrome | D013577 | — | — | — | 5 | 2 | — | 1 | 8 |
| Burkitt lymphoma | D002051 | — | C83.7 | 1 | 5 | 1 | — | — | 7 |
| Arthritis | D001168 | EFO_0005856 | M05-M14 | 1 | 3 | 4 | — | — | 7 |
| Neoplasms | D009369 | — | C80 | 1 | 5 | 1 | — | — | 6 |
| Joint diseases | D007592 | — | M12.9 | — | 2 | 4 | — | — | 6 |
| Musculoskeletal diseases | D009140 | — | — | — | — | 5 | — | — | 5 |
Show 38 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myelodysplastic syndromes | D009190 | — | D46 | 3 | 7 | — | — | 1 | 10 |
| Lymphoid leukemia | D007945 | — | C91 | 3 | 7 | — | — | — | 9 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 6 | — | — | 1 | 8 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 3 | 6 | — | — | — | 7 |
| Multiple myeloma | D009101 | — | C90.0 | 2 | 5 | — | — | — | 7 |
| Myeloproliferative disorders | D009196 | — | D47.1 | 2 | 5 | — | — | — | 6 |
| Plasma cell neoplasms | D054219 | — | — | 2 | 3 | — | — | — | 5 |
| Follicular lymphoma | D008224 | — | C82 | 2 | 4 | — | — | — | 5 |
| Myeloid leukemia | D007951 | — | C92 | — | 5 | — | — | — | 5 |
| Preleukemia | D011289 | — | — | — | 4 | — | — | — | 4 |
Show 48 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 6 | — | — | — | — | 6 |
| Heart disease risk factors | D000082742 | — | — | 3 | — | — | — | — | 3 |
| Vasoconstriction | D014661 | — | — | 2 | — | — | — | — | 2 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | 1 | — | — | — | — | 1 |
| Graft vs host disease | D006086 | — | D89.81 | 1 | — | — | — | — | 1 |
| Sezary syndrome | D012751 | — | C84.1 | 1 | — | — | — | — | 1 |
| Leukemia myeloid chronic atypical bcr-abl negative | D054438 | — | C92.2 | 1 | — | — | — | — | 1 |
| Large-cell lymphoma anaplastic | D017728 | — | C84.6 | 1 | — | — | — | — | 1 |
| Immunoblastic lymphadenopathy | D007119 | EFO_1001350 | C86.5 | 1 | — | — | — | — | 1 |
| Mycosis fungoides | D009182 | — | C84.0 | 1 | — | — | — | — | 1 |
Show 11 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Apnea | D001049 | — | R06.81 | — | — | — | — | 2 | 2 |
| Rheumatic fever | D012213 | EFO_1001160 | I00-I02 | — | — | — | — | 1 | 1 |
| Patient compliance | D010349 | — | — | — | — | — | — | 1 | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 1 | 1 |
| Eisenmenger complex | D004541 | — | I27.83 | — | — | — | — | 1 | 1 |
| Stevens-johnson syndrome | D013262 | EFO_0004276 | L51.1 | — | — | — | — | 1 | 1 |
| Pancreatitis | D010195 | EFO_0000278 | K85 | — | — | — | — | 1 | 1 |
| Endoscopic retrograde cholangiopancreatography | D002760 | — | — | — | — | — | — | 1 | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | — | — | — | — | 1 | 1 |
| Fetal growth retardation | D005317 | EFO_0000495 | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Allopurinol |
| INN | allopurinol |
| Description | Allopurinol is a bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. It has a role as a radical scavenger, a gout suppressant, an antimetabolite and an EC 1.17.3.2 (xanthine oxidase) inhibitor. It is an organic heterobicyclic compound and a nucleobase analogue. It derives from a hydride of a 1H-pyrazolo[4,3-d]pyrimidine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1ncnc2[nH]ncc12 |
Identifiers
| PDB | — |
| CAS-ID | 315-30-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1467 |
| ChEBI ID | 40279 |
| PubChem CID | 135401907 |
| DrugBank | DB00437 |
| UNII ID | 63CZ7GJN5I (ChemIDplus, GSRS) |
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Allopurinol
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Safety
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26,336 adverse events reported
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