Lopurin, Duzallo(allopurinol)
Allopurinol, Aloprim, Duzallo, Lopurin, Zyloprim (allopurinol) is a small molecule pharmaceutical. Allopurinol was first approved as Lopurin on 1982-01-01. It is used to treat gout in the USA. It has been approved in Europe to treat gout. The pharmaceutical is active against xanthine dehydrogenase/oxidase.
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Commercial
Therapeutic Areas
Trade Name
FDA
EMA
Allopurinol, Aloprim, Lopurin, Zyloprim (discontinued: Allopurinol, Lopurin)
Drug Products
FDA
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Allopurinol sodium
Allopurinol
Allopurinol
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Lesinurad
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| DUZALLO | Ironwood Pharmaceuticals | N-209203 DISCN | 2017-08-18 | 2 products, RLD |
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FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| allopurinol | ANDA | 2025-10-02 |
| allopurinol sodium | ANDA | 2022-03-01 |
| aloprim | New Drug Application | 2022-02-18 |
| zyloprim | ANDA | 2018-02-24 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| gout | EFO_0004274 | D006073 | M10 |
| hyperuricemia | — | D033461 | — |
Agency Specific
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Clinical
Clinical Trials
220 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | — | N18 | — | — | — | 1 | — | 1 |
| Gout | D006073 | EFO_0004274 | M10 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Allopurinol |
| INN | allopurinol |
| Description | Allopurinol is a bicyclic structure comprising a pyrazole ring fused to a hydroxy-substituted pyrimidine ring. It has a role as a radical scavenger, a gout suppressant, an antimetabolite and an EC 1.17.3.2 (xanthine oxidase) inhibitor. It is an organic heterobicyclic compound and a nucleobase analogue. It derives from a hydride of a 1H-pyrazolo[4,3-d]pyrimidine. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Oc1ncnc2[nH]ncc12 |
Identifiers
| PDB | — |
| CAS-ID | 315-30-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1467 |
| ChEBI ID | 40279 |
| PubChem CID | 135401907 |
| DrugBank | DB00437 |
| UNII ID | 63CZ7GJN5I (ChemIDplus, GSRS) |
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Estimated US medical usage
Allopurinol
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Additional graphs summarizing 21,180 documents
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Safety
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26,094 adverse events reported
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