Alisertib
Alisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against aurora kinase A.
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Commercial
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Clinical
Clinical Trials
64 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphoma | D008223 | — | C85.9 | 13 | 4 | 1 | — | — | 17 |
| T-cell lymphoma | D016399 | — | — | 3 | 2 | 1 | — | — | 6 |
| T-cell lymphoma peripheral | D016411 | — | — | 2 | 2 | 1 | — | — | 5 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 21 | 4 | — | — | — | 24 |
| Recurrence | D012008 | — | — | 5 | 6 | — | — | — | 11 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 4 | 5 | — | — | — | 8 |
| Mantle-cell lymphoma | D020522 | — | — | 5 | 3 | — | — | — | 7 |
| B-cell lymphoma | D016393 | — | — | 6 | 2 | — | — | — | 7 |
| Adenocarcinoma | D000230 | — | — | 5 | 1 | — | — | 1 | 7 |
| Lung neoplasms | D008175 | HP_0100526 | C34.90 | 4 | 5 | — | — | — | 7 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 3 | 3 | — | — | — | 6 |
| Follicular lymphoma | D008224 | — | C82 | 5 | 2 | — | — | — | 6 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 4 | 3 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Head and neck neoplasms | D006258 | — | — | 2 | — | — | — | — | 2 |
| Gastrointestinal neoplasms | D005770 | — | C26.9 | 2 | — | — | — | — | 2 |
| Digestive system neoplasms | D004067 | — | — | 2 | — | — | — | — | 2 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | — | — | — | — | 2 |
| B-cell chronic lymphocytic leukemia | D015451 | — | C91.1 | 2 | — | — | — | — | 2 |
| Colorectal neoplasms | D015179 | — | — | 1 | — | — | — | — | 1 |
| Mucinous adenocarcinoma | D002288 | — | — | 1 | — | — | — | — | 1 |
| Colonic neoplasms | D003110 | — | C18 | 1 | — | — | — | — | 1 |
| Rectal neoplasms | D012004 | — | — | 1 | — | — | — | — | 1 |
| Cystadenocarcinoma | D003536 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary myelofibrosis | D055728 | — | D47.4 | — | — | — | — | 1 | 1 |
| Megakaryoblastic leukemia acute | D007947 | — | C94.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Alisertib |
| INN | alisertib |
| Description | 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid is a benzazepine. |
| Classification | Small molecule |
| Drug class | serine/threonine kinase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 1028486-01-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL483158 |
| ChEBI ID | — |
| PubChem CID | 24771867 |
| DrugBank | — |
| UNII ID | T66ES73M18 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
EPHA2
EPHA2
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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115 adverse events reported
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