Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Hypertension | D006973 | EFO_0000537 | I10 | 5 | 9 | 6 | 19 | 46 | 84 |
Hyperaldosteronism | D006929 | HP_0011736 | E26 | 1 | 2 | 1 | 4 | 59 | 66 |
Heart failure | D006333 | HP_0001635 | I50 | 2 | 9 | 13 | 8 | 30 | 61 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | 4 | 9 | 9 | 11 | 31 |
Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 2 | 1 | 3 | 8 | 15 |
Chronic renal insufficiency | D051436 | — | N18 | — | 2 | 2 | 4 | 7 | 15 |
Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | 1 | 1 | 3 | 1 | 9 | 14 |
Covid-19 | D000086382 | — | — | — | 2 | 3 | 1 | 9 | 13 |
Cardiovascular diseases | D002318 | HP_0001626 | — | — | 3 | 3 | 2 | 6 | 13 |
Syndrome | D013577 | — | — | 2 | 1 | 1 | 2 | 6 | 12 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Myocardial infarction | D009203 | EFO_0000612 | I21 | — | 1 | 3 | — | 6 | 10 |
Infarction | D007238 | EFO_0009463 | — | — | 1 | 3 | — | 6 | 10 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 2 | 1 | — | — | 3 |
Renin-angiotensin system | D012084 | — | — | 1 | 2 | 1 | — | 1 | 3 |
Ventricular remodeling | D020257 | — | — | — | — | 1 | — | 2 | 3 |
Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | 1 | — | 1 | 2 |
Polycystic kidney diseases | D007690 | HP_0000113 | Q61.3 | — | — | 2 | — | — | 2 |
Coronary disease | D003327 | — | — | — | — | 1 | — | 1 | 2 |
Duchenne muscular dystrophy | D020388 | EFO_0000429 | — | — | — | 1 | — | 1 | 2 |
Muscular dystrophies | D009136 | HP_0003560 | G71.0 | — | — | 1 | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Ventricular dysfunction | D018754 | — | — | — | 1 | — | — | 3 | 4 |
Hiv infections | D015658 | EFO_0000764 | B20 | — | 2 | — | — | 1 | 3 |
Vitamin d deficiency | D014808 | EFO_0003762 | E55 | — | 1 | — | — | 1 | 2 |
Psychological stress | D013315 | — | — | — | 1 | — | — | 1 | 2 |
Wounds and injuries | D014947 | — | T14.8 | — | 1 | — | — | 1 | 2 |
Arrhythmogenic right ventricular dysplasia | D019571 | Orphanet_247 | I42.8 | — | 1 | — | — | — | 1 |
Right ventricular dysfunction | D018497 | — | — | — | 1 | — | — | — | 1 |
Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | — | 1 |
Congenital heart defects | D006330 | HP_0001627 | Q24.9 | — | 1 | — | — | — | 1 |
Tetralogy of fallot | D013771 | HP_0001636 | Q21.3 | — | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Postural orthostatic tachycardia syndrome | D054972 | — | G90.A | 1 | — | — | — | 2 | 3 |
Tachycardia | D013610 | HP_0001649 | R00.0 | 1 | — | — | — | 2 | 3 |
Glucose metabolism disorders | D044882 | — | — | 1 | — | — | — | 1 | 2 |
Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 1 | 2 |
Metabolic diseases | D008659 | EFO_0000589 | E88.9 | 1 | — | — | — | — | 1 |
Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | 1 | — | — | — | — | 1 |
Therapeutic equivalency | D013810 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Adenoma | D000236 | — | — | — | — | — | — | 15 | 15 |
Adrenocortical adenoma | D018246 | — | — | — | — | — | — | 8 | 8 |
Hyperplasia | D006965 | EFO_0000536 | — | — | — | — | — | 6 | 6 |
Congenital adrenal hyperplasia | D000312 | — | E25.0 | — | — | — | — | 6 | 6 |
Adrenogenital syndrome | D047808 | — | E25.9 | — | — | — | — | 6 | 6 |
Cushing syndrome | D003480 | EFO_0003099 | E24 | — | — | — | — | 6 | 6 |
Left ventricular dysfunction | D018487 | — | — | — | — | — | — | 4 | 4 |
Adrenocortical hyperfunction | D000308 | EFO_1000797 | — | — | — | — | — | 4 | 4 |
Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 3 | 3 |
Pituitary acth hypersecretion | D047748 | EFO_1001110 | E24.0 | — | — | — | — | 3 | 3 |
Drug common name | Aldosterone |
INN | aldosterone |
Description | Aldosterone is a pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. It has a role as a human metabolite and a mouse metabolite. It is an 11beta-hydroxy steroid, a 21-hydroxy steroid, a 18-oxo steroid, a 20-oxo steroid, a C21-steroid hormone, a steroid aldehyde, a 3-oxo-Delta(4) steroid, a primary alpha-hydroxy ketone and a mineralocorticoid. It derives from a hydride of a pregnane. |
Classification | Small molecule |
Drug class | steroids (androgens, anabolics); antiandrogens |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C=O)[C@@H](C(=O)CO)CC[C@@H]12 |
PDB | — |
CAS-ID | 52-39-1 |
RxCUI | — |
ChEMBL ID | CHEMBL273453 |
ChEBI ID | 27584 |
PubChem CID | 5839 |
DrugBank | DB04630 |
UNII ID | 4964P6T9RB (ChemIDplus, GSRS) |