Adefovir
Adefovir Dipivoxil, Hepsera (adefovir) is a small molecule pharmaceutical. Adefovir was first approved as Hepsera on 2002-09-20. It is used to treat chronic hepatitis b and hepatitis b in the USA. It has been approved in Europe to treat chronic hepatitis b.
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Brand Name | Status | Last Update |
|---|---|---|
| adefovir dipivoxil | ANDA | 2024-09-17 |
| hepsera | New Drug Application | 2009-10-27 |
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147 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis b | D006509 | — | — | 1 | — | 3 | 9 | 2 | 15 |
| Chronic hepatitis b | D019694 | EFO_0004239 | B18.1 | 1 | — | 2 | 9 | — | 12 |
| Hepatitis | D006505 | HP_0012115 | K75.9 | — | — | 3 | 8 | — | 11 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | 3 | 8 | — | 11 |
| Chronic hepatitis | D006521 | — | K73.9 | — | — | 2 | 6 | — | 8 |
| Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | 1 | — | 1 |
| Fibrosis | D005355 | — | — | — | — | — | 1 | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Adefovir |
| INN | adefovir |
| Description | Adefovir is a member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens has been replaced by a 2-(6-amino-9H-purin-9-yl)ethoxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(t-butoxycarbonyloxymethyl) ester (dipivoxil ester) prodrug is used to treat chronic hepatitis B viral infection. It has a role as a HIV-1 reverse transcriptase inhibitor, a drug metabolite, an antiviral drug, a nephrotoxic agent and a DNA synthesis inhibitor. It is a member of 6-aminopurines, an ether and a member of phosphonic acids. It is functionally related to an adenine. It is a conjugate acid of an adefovir(1-). |
| Classification | Small molecule |
| Drug class | antivirals |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1ncnc2c1ncn2CCOCP(=O)(O)O |
Identifiers
| PDB | — |
| CAS-ID | 106941-25-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL484 |
| ChEBI ID | — |
| PubChem CID | 60172 |
| DrugBank | DB00718 |
| UNII ID | 6GQP90I798 (ChemIDplus, GSRS) |
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Hepsera – Gilead Sciences
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Estimated US medical usage
Adefovir
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Safety
Black-box Warning
Black-box warning for: Adefovir dipivoxil, Hepsera
Adverse Events
Top Adverse Reactions
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4,165 adverse events reported
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