Acyclovir
Acyclovir, Sitavig, Xerese, Zovirax (acyclovir) is a small molecule pharmaceutical. Acyclovir was first approved as Zovirax on 1982-03-29. It is used to treat aids-related opportunistic infections, chickenpox, epstein-barr virus infections, herpes genitalis, and herpes labialis amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Acyclovir, Zovirax (discontinued: Acyclovir, Avaclyr, Zovirax)
CombinationsXerese
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acyclovir
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZOVIRAX | Bausch Health Companies | N-018604 RX | 1982-03-29 | 1 products, RLD, RS |
| ZOVIRAX | Bausch Health Companies | N-021478 RX | 2002-12-30 | 1 products, RLD |
Show 4 discontinued
Acyclovir sodium
Acyclovir
+
Hydrocortisone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XERESE | Bausch Health Companies | N-022436 RX | 2009-07-31 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acyclovir | ANDA | 2025-06-11 |
| acyclovir sodium | ANDA | 2025-05-29 |
| acyclovir suspension | ANDA | 2023-11-03 |
| acyclovir valacyclovir valacyclovir hydrochloride | ANDA | 2023-06-29 |
| averteax | OTC monograph not final | 2014-03-08 |
| lornamead | OTC monograph final | 2013-03-06 |
| lypsyl honeyberry | OTC monograph final | 2018-12-27 |
| lypsyl vanilla plum | OTC monograph not final | 2013-12-13 |
| sitavig | New Drug Application | 2020-06-11 |
| sitivig | New Drug Application | 2014-03-13 |
Show 3 more
Indications
FDA
EMA
Show 14 more
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ACYCLOVIR, AVACLYR, FERA PHARMS LLC | |||
| 2026-03-29 | ODE-235 | ||
ACYCLOVIR, ACYCLOVIR, ALEMBIC | |||
| 2024-06-12 | CGT | ||
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06B: Chemotherapeutics for topical use
— D06BB: Antivirals, topical
— D06BB03: Aciclovir
— D06BB53: Aciclovir, combinations
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB01: Aciclovir
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD03: Aciclovir
HCPCS
Code | Description |
|---|---|
| J0133 | Injection, acyclovir, 5 mg |
Clinical
Clinical Trials
187 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Herpes simplex | D006561 | — | B00 | 6 | 12 | 22 | 8 | 18 | 62 |
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 6 | 7 | 3 | 18 | 35 |
| Infections | D007239 | EFO_0000544 | — | 2 | 1 | 7 | 2 | 14 | 26 |
| Communicable diseases | D003141 | — | — | 1 | — | 4 | 2 | 12 | 19 |
| Herpes labialis | D006560 | EFO_1001347 | B00.1 | 2 | 5 | 7 | 1 | 2 | 17 |
| Herpes genitalis | D006558 | EFO_0007282 | A60 | — | 2 | 3 | 5 | 3 | 13 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | 2 | 2 | 5 | 9 |
| Keratitis | D007634 | — | H16 | — | — | 2 | 2 | 3 | 7 |
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 3 | — | 1 | 1 | — | 5 |
| Sclerosis | D012598 | — | — | 3 | — | 1 | 1 | — | 5 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Acquired immunodeficiency syndrome | D000163 | EFO_0000765 | B20 | — | — | 3 | — | 6 | 9 |
| Virus diseases | D014777 | — | B34 | 2 | — | 1 | — | 3 | 6 |
| Ulcer | D014456 | MPATH_579 | — | — | 2 | 1 | — | 2 | 4 |
| Chickenpox | D002644 | EFO_0007204 | B01 | — | 1 | 1 | — | 1 | 3 |
| Varicella zoster virus infection | D000073618 | — | — | — | — | 1 | — | 2 | 3 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 2 | — | — | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | 1 | 2 |
| Carcinoma | D002277 | — | C80.0 | — | 1 | 1 | — | — | 2 |
| Vertigo | D014717 | — | H81.39 | — | 2 | 1 | — | — | 2 |
| Herpes simplex encephalitis | D020803 | — | B00.4 | — | — | 1 | — | 1 | 2 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 4 | — | — | — | 4 |
| Lung neoplasms | D008175 | — | C34.90 | — | 4 | — | — | — | 4 |
| Multiple myeloma | D009101 | — | C90.0 | 1 | 2 | — | — | — | 3 |
| Plasma cell neoplasms | D054219 | — | — | 1 | 2 | — | — | — | 3 |
| Lymphoma | D008223 | — | C85.9 | 1 | 2 | — | — | — | 2 |
| Prostatic neoplasms | D011471 | — | C61 | — | 2 | — | — | — | 2 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | — | 1 | — | — | 1 | 2 |
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | 1 | 2 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | — | — | 1 | 2 |
| Simplexvirus | D018139 | — | — | 2 | 1 | — | — | — | 2 |
Show 33 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 2 | 3 |
| Chronic progressive multiple sclerosis | D020528 | EFO_0003840 | — | 3 | — | — | — | — | 3 |
| Premature birth | D047928 | EFO_0003917 | O60 | 1 | — | — | — | 1 | 2 |
| Glioma | D005910 | EFO_0000520 | — | 2 | — | — | — | — | 2 |
| Facial paralysis | D005158 | — | G51.0 | 1 | — | — | — | 1 | 2 |
| Bell palsy | D020330 | EFO_0007167 | G51.0 | 1 | — | — | — | 1 | 2 |
| Paralysis | D010243 | — | — | 1 | — | — | — | 1 | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Infectious pregnancy complications | D011251 | — | — | 1 | — | — | — | — | 1 |
Show 6 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Herpesviridae infections | D006566 | EFO_0007309 | B00.4 | — | — | — | — | 4 | 4 |
| Neuralgia | D009437 | EFO_0009430 | — | — | — | — | — | 3 | 3 |
| Lymphatic diseases | D008206 | — | — | — | — | — | — | 3 | 3 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | — | — | — | 3 | 3 |
| Postherpetic neuralgia | D051474 | — | — | — | — | — | — | 2 | 2 |
| Cesarean section | D002585 | — | — | — | — | — | — | 2 | 2 |
| Papillomaviridae | D027383 | — | — | — | — | — | — | 1 | 1 |
| Papilloma | D010212 | — | — | — | — | — | — | 1 | 1 |
| Aseptic meningitis | D008582 | EFO_1000823 | G03.0 | — | — | — | — | 1 | 1 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | — | 1 | 1 |
Show 38 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acyclovir |
| INN | aciclovir |
| Description | Aciclovir, also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection. It can be taken by mouth, applied as a cream, or injected.
|
| Classification | Small molecule |
| Drug class | antivirals: antivirals (acyclovir type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2c(ncn2COCCO)c(=O)[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 59277-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL184 |
| ChEBI ID | 2453 |
| PubChem CID | 2022 |
| DrugBank | DB00787 |
| UNII ID | X4HES1O11F (ChemIDplus, GSRS) |
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Acyclovir
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Additional graphs summarizing 68,035 documents
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Safety
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Adverse Events
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37,587 adverse events reported
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