Acyclovir
Acyclovir, Sitavig, Xerese, Zovirax (acyclovir) is a small molecule pharmaceutical. Acyclovir was first approved as Zovirax on 1982-03-29. It is used to treat aids-related opportunistic infections, chickenpox, epstein-barr virus infections, herpes genitalis, and herpes labialis amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Sitavig, Zovirax (generic drugs available since 1997-04-22, discontinued: Avaclyr, Zovirax)
CombinationsXerese
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acyclovir
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| ZOVIRAX | Bausch Health Companies | N-018604 RX | 1982-03-29 | 1 products, RLD, RS |
| ZOVIRAX | Bausch Health Companies | N-021478 RX | 2002-12-30 | 1 products, RLD |
| SITAVIG | LNHC | N-203791 RX | 2013-04-12 | 1 products, RLD, RS |
Show 4 discontinued
Acyclovir
+
Hydrocortisone
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| XERESE | Bausch Health Companies | N-022436 RX | 2009-07-31 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acyclovir | ANDA | 2024-02-13 |
| acyclovir sodium | ANDA | 2023-07-05 |
| acyclovir suspension | ANDA | 2023-11-03 |
| acyclovir valacyclovir valacyclovir hydrochloride | ANDA | 2023-06-29 |
| acyclovix | ANDA | 2020-09-21 |
| averteax | OTC monograph not final | 2014-03-08 |
| jet-avert motion sickness aid | C200263 | 2023-12-15 |
| lornamead | OTC monograph final | 2013-03-06 |
| lypsyl honeyberry | OTC monograph final | 2018-12-27 |
| lypsyl vanilla plum | OTC monograph not final | 2013-12-13 |
Show 6 more
Indications
FDA
EMA
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ACYCLOVIR, AVACLYR, FERA PHARMS LLC | |||
| 2026-03-29 | ODE-235 | ||
ACYCLOVIR, ACYCLOVIR, ALEMBIC | |||
| 2024-06-12 | CGT | ||
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06B: Chemotherapeutics for topical use
— D06BB: Antivirals, topical
— D06BB03: Aciclovir
— D06BB53: Aciclovir, combinations
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB01: Aciclovir
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD03: Aciclovir
HCPCS
Code | Description |
|---|---|
| J0133 | Injection, acyclovir, 5 mg |
Clinical
Clinical Trials
182 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 3 | 6 | 7 | 3 | 18 | 35 |
| Herpes simplex | D006561 | — | B00 | 4 | 4 | 11 | 1 | 11 | 28 |
| Herpes labialis | D006560 | EFO_1001347 | B00.1 | 2 | 5 | 7 | 1 | 2 | 17 |
| Herpes genitalis | D006558 | EFO_0007282 | A60 | — | 2 | 3 | 5 | 2 | 12 |
| Herpetic keratitis | D016849 | EFO_0007308 | — | — | — | 2 | 2 | — | 4 |
| Pain | D010146 | EFO_0003843 | R52 | — | — | — | 1 | 2 | 3 |
| Hepatitis b | D006509 | — | — | — | — | — | 2 | — | 2 |
| Healthy volunteers/patients | — | — | — | 1 | — | — | 1 | — | 2 |
| Papillomavirus infections | D030361 | — | — | — | — | 1 | 1 | — | 2 |
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | 1 | 1 | — | 2 |
Show 5 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 3 | — | 1 | — | — | 4 |
| Ulcer | D014456 | MPATH_579 | — | — | 2 | 1 | — | 1 | 3 |
| Infections | D007239 | EFO_0000544 | — | — | — | 1 | — | 1 | 2 |
| Chickenpox | D002644 | EFO_0007204 | B01 | — | 1 | 1 | — | — | 2 |
| Respiratory tract infections | D012141 | — | J06.9 | — | — | 1 | — | — | 1 |
| Cardiovascular diseases | D002318 | HP_0001626 | — | — | — | 1 | — | — | 1 |
| Covid-19 | D000086382 | — | U07.1 | — | — | 1 | — | — | 1 |
| Meniere disease | D008575 | EFO_0006862 | H81.0 | — | 1 | 1 | — | — | 1 |
| Bone marrow transplantation | D016026 | — | — | — | — | 1 | — | — | 1 |
| Cytomegalovirus | D003587 | — | — | — | — | 1 | — | — | 1 |
Show 6 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | — | — | 4 | — | — | — | 4 |
| Simplexvirus | D018139 | — | — | 2 | 1 | — | — | — | 2 |
| Hemolytic anemia autoimmune | D000744 | EFO_1001264 | D59.10 | — | 1 | — | — | — | 1 |
| Multiple myeloma | D009101 | — | C90.0 | — | 1 | — | — | — | 1 |
| Waldenstrom macroglobulinemia | D008258 | HP_0005508 | C88.0 | — | 1 | — | — | — | 1 |
| Large b-cell lymphoma diffuse | D016403 | — | C83.3 | 1 | 1 | — | — | — | 1 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | — | 1 | — | — | — | 1 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 1 | 1 | — | — | — | 1 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 1 | 1 | — | — | — | 1 |
| Philadelphia chromosome | D010677 | — | — | 1 | 1 | — | — | — | 1 |
Show 15 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 2 | 3 |
| Glioma | D005910 | EFO_0000520 | — | 2 | — | — | — | — | 2 |
| Glioblastoma | D005909 | EFO_0000515 | — | 1 | — | — | — | — | 1 |
| Astrocytoma | D001254 | EFO_0000271 | — | 1 | — | — | — | — | 1 |
| Bell palsy | D020330 | EFO_0007167 | G51.0 | 1 | — | — | — | — | 1 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 1 | — | — | — | — | 1 |
| Neonatal sepsis | D000071074 | HP_0040187 | — | 1 | — | — | — | — | 1 |
| Hemorrhoids | D006484 | EFO_0009552 | K64 | 1 | — | — | — | — | 1 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphatic diseases | D008206 | HP_0100763 | — | — | — | — | — | 3 | 3 |
| Varicella zoster virus infection | D000073618 | — | — | — | — | — | — | 2 | 2 |
| Premature birth | D047928 | EFO_0003917 | O60 | — | — | — | — | 1 | 1 |
| Papillomaviridae | D027383 | — | — | — | — | — | — | 1 | 1 |
| Postherpetic neuralgia | D051474 | — | — | — | — | — | — | 1 | 1 |
| Aseptic meningitis | D008582 | EFO_1000823 | G03.0 | — | — | — | — | 1 | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | — | — | 1 | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
| Drug monitoring | D016903 | — | — | — | — | — | — | 1 | 1 |
| Photochemotherapy | D010778 | — | — | — | — | — | — | 1 | 1 |
Show 21 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acyclovir |
| INN | aciclovir |
| Description | Aciclovir, also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and severe complications of Epstein–Barr virus infection. It can be taken by mouth, applied as a cream, or injected.
|
| Classification | Small molecule |
| Drug class | antivirals: antivirals (acyclovir type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2c(ncn2COCCO)c(=O)[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 59277-89-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL184 |
| ChEBI ID | 2453 |
| PubChem CID | 2022 |
| DrugBank | DB00787 |
| UNII ID | X4HES1O11F (ChemIDplus, GSRS) |
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Acyclovir
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Trends
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Additional graphs summarizing 60,521 documents
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Safety
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Adverse Events
Top Adverse Reactions
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26,058 adverse events reported
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