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Drug ReportsAcoltremon
Acoltremon
Tryptyr (acoltremon) is a small molecule pharmaceutical. Acoltremon was first approved as Tryptyr on 2025-05-28.
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Drug
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Financial
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Events Timeline
5D
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YTD
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FDA approval date
EMA approval date
Patent expiration date
Study first post date
Last update post date
Start date
Primary completion date
Completion date
Results first post date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Tryptyr
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acoltremon
Tradename
Company
Number
Date
Products
TRYPTYRAlcon ResearchN-217370 RX2025-05-28
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
tryptyrNew Drug Application2025-12-18
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
dry eye syndromes—D015352H04.12
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
23 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Dry eye syndromesD015352—H04.12——32—5
Eye painD058447—H57.1———1—1
Indications Phases 3
No data
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAcoltremon
INNacoltremon
Description
Acoltremon sold under the brand name Tryptyr, is a medication used for the treatment of dry eye syndrome.
Classification
Small molecule
Drug classtransient receptor potential cation cannel subfamily M member 8 (TRPM8) agonists [also known as the cold and menthol receptor 1 (CMR1)]
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Structure (InChI/SMILES or Protein Sequence)
COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1
Identifiers
PDB—
CAS-ID68489-09-8
RxCUI—
ChEMBL IDCHEMBL2441929
ChEBI ID—
PubChem CID11266244
DrugBankDB19202
UNII ID1L7BVT4Z4Z (ChemIDplus, GSRS)
Target
No data
Variants
No data
Financial
No data
Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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3,009 adverse events reported
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