Acoltremon
Tryptyr (acoltremon) is a small molecule pharmaceutical. Acoltremon was first approved as Tryptyr on 2025-05-28.
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Events Timeline
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FDA approval date
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
Tryptyr
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acoltremon
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TRYPTYR | Alcon Research | N-217370 RX | 2025-05-28 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| tryptyr | New Drug Application | 2025-07-30 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| dry eye syndromes | — | D015352 | H04.12 |
Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Dry eye syndromes | D015352 | — | H04.12 | 2 | 2 | 6 | — | — | 9 |
| Eye diseases | D005128 | EFO_0003966 | H44 | 1 | 1 | 6 | — | — | 8 |
| Keratoconjunctivitis sicca | D007638 | EFO_1000906 | — | 1 | 2 | 4 | — | — | 6 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acoltremon |
| INN | acoltremon |
| Description | Acoltremon sold under the brand name Tryptyr, is a medication used for the treatment of dry eye syndrome.
|
| Classification | Small molecule |
| Drug class | transient receptor potential cation cannel subfamily M member 8 (TRPM8) agonists [also known as the cold and menthol receptor 1 (CMR1)] |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | COc1ccc(NC(=O)[C@@H]2C[C@H](C)CC[C@H]2C(C)C)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 68489-09-8 |
| RxCUI | — |
| ChEMBL ID | CHEMBL2441929 |
| ChEBI ID | — |
| PubChem CID | 11266244 |
| DrugBank | DB19202 |
| UNII ID | 1L7BVT4Z4Z (ChemIDplus, GSRS) |
Target
No data
Variants
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Financial
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Trends
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Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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