Aclarubicin
Aclarubicin is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Clinical Trials
25 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 8 | 6 | 1 | 6 | 21 |
| Leukemia | D007938 | — | C95 | — | 6 | 5 | 1 | 5 | 17 |
| Myeloid leukemia | D007951 | — | C92 | — | 6 | 4 | 1 | 5 | 16 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Induction chemotherapy | D060828 | — | — | — | — | 3 | — | — | 3 |
| Recurrence | D012008 | — | — | 1 | 1 | 1 | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | — | — | 1 | — | — | 1 |
| Precursor t-cell lymphoblastic leukemia-lymphoma | D054218 | — | — | — | — | 1 | — | — | 1 |
| T-cell leukemia | D015458 | — | — | — | — | 1 | — | — | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Aclarubicin |
| INN | aclarubicin |
| Description | Aclarubicin (INN) or aclacinomycin A is an anthracycline drug that is used in the treatment of cancer. Soil bacteria Streptomyces galilaeus can produce aclarubicin. It can induce histone eviction from chromatin upon intercalation.
|
| Classification | Small molecule |
| Drug class | antineoplastic antibiotics (daunorubicin type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC[C@@]1(O)C[C@H](O[C@H]2C[C@H](N(C)C)[C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)c2c(cc3c(c2O)C(=O)c2c(O)cccc2C3=O)[C@H]1C(=O)OC |
Identifiers
| PDB | — |
| CAS-ID | 57576-44-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL502620 |
| ChEBI ID | 77980 |
| PubChem CID | 42474 |
| DrugBank | — |
| UNII ID | 74KXF8I502 (ChemIDplus, GSRS) |
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Safety
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363 adverse events reported
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