Acipimox
Acipimox is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target hydroxycarboxylic acid receptor 2.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
FDA
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Agency Specific
FDA
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | 2 | 1 | — | 3 | 5 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | 2 | 2 | — | 2 | 5 |
| Metabolic syndrome | D024821 | EFO_0000195 | E88.810 | — | 1 | 1 | — | 1 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 1 | — | 1 | — | — | 2 |
| Syndrome | D013577 | — | — | — | 1 | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Insulin resistance | D007333 | HP_0000855 | — | — | 1 | — | — | 4 | 5 |
| Heart failure | D006333 | HP_0001635 | I50 | 1 | 1 | — | — | 1 | 3 |
| Obesity | D009765 | EFO_0001073 | E66.9 | — | 1 | — | — | 1 | 2 |
| Hypertriglyceridemia | D015228 | EFO_0004211 | — | — | 1 | — | — | 1 | 2 |
| Abdominal obesity | D056128 | HP_0001956 | — | — | 1 | — | — | — | 1 |
| Bulimia | D002032 | — | F50.2 | — | 1 | — | — | — | 1 |
| Feeding and eating disorders | D001068 | — | F50 | — | 1 | — | — | — | 1 |
| Bulimia nervosa | D052018 | EFO_0005204 | F50.2 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 2 | 3 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prediabetic state | D011236 | EFO_1001121 | R73.03 | — | — | — | — | 3 | 3 |
| Hypopituitarism | D007018 | EFO_0001380 | E23.0 | — | — | — | — | 2 | 2 |
| Glucose metabolism disorders | D044882 | — | — | — | — | — | — | 1 | 1 |
| Metabolic diseases | D008659 | EFO_0000589 | E88.9 | — | — | — | — | 1 | 1 |
| Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | — | — | — | 1 | 1 |
| Brain diseases | D001927 | HP_0001298 | G93.40 | — | — | — | — | 1 | 1 |
| Pituitary diseases | D010900 | — | E23.7 | — | — | — | — | 1 | 1 |
| Metabolism | D008660 | GO_0008152 | — | — | — | — | — | 1 | 1 |
| Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 1 | 1 |
| Dilated cardiomyopathy | D002311 | HP_0001644 | I42.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acipimox |
| INN | acipimox |
| Description | 5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid is a pyrazinecarboxylic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cnc(C(=O)O)c[n+]1[O-] |
Identifiers
| PDB | — |
| CAS-ID | 51037-30-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL345714 |
| ChEBI ID | — |
| PubChem CID | 5310993 |
| DrugBank | — |
| UNII ID | K9AY9IR2SD (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HCAR2
HCAR2
Organism
Homo sapiens
Gene name
HCAR2
Gene synonyms
GPR109A, HCA2, HM74A, NIACR1
NCBI Gene ID
Protein name
hydroxycarboxylic acid receptor 2
Protein synonyms
G protein-coupled receptor HM74a, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, hydroxy-carboxylic acid receptor 2, Niacin receptor 1, Nicotinic acid receptor
Uniprot ID
Mouse ortholog
Hcar2 (80885)
hydroxycarboxylic acid receptor 2 (Q9EP66)
Variants
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Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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145 adverse events reported
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