Acipimox
Acipimox is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target hydroxycarboxylic acid receptor 2.
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | — | 1 | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acipimox |
| INN | acipimox |
| Description | 5-methyl-4-oxido-2-pyrazin-4-iumcarboxylic acid is a pyrazinecarboxylic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cnc(C(=O)O)c[n+]1[O-] |
Identifiers
| PDB | — |
| CAS-ID | 51037-30-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL345714 |
| ChEBI ID | — |
| PubChem CID | 5310993 |
| DrugBank | — |
| UNII ID | K9AY9IR2SD (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
HCAR2
HCAR2
Organism
Homo sapiens
Gene name
HCAR2
Gene synonyms
GPR109A, HCA2, HM74A, NIACR1
NCBI Gene ID
Protein name
hydroxycarboxylic acid receptor 2
Protein synonyms
G protein-coupled receptor HM74a, G-protein coupled receptor 109A, G-protein coupled receptor HM74A, hydroxy-carboxylic acid receptor 2, Niacin receptor 1, Nicotinic acid receptor
Uniprot ID
Mouse ortholog
Hcar2 (80885)
hydroxycarboxylic acid receptor 2 (Q9EP66)
Variants
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Trends
PubMed Central
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Additional graphs summarizing 823 documents
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Safety
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145 adverse events reported
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