Acetazolamide
Diamox (acetazolamide) is a small molecule pharmaceutical. Acetazolamide was first approved as Diamox on 1982-01-01. It is used to treat altitude sickness, glaucoma, and seizures in the USA. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 14, carbonic anhydrase 12, carbonic anhydrase 1, carbonic anhydrase 13, and carbonic anhydrase 4.
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Commercial
Therapeutic Areas
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| acetazolamide | ANDA | 2024-02-05 |
| acetazolamide extended-release | ANDA | 2024-01-09 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| altitude sickness | EFO_1000782 | D000532 | T70.29 |
| glaucoma | EFO_0000516 | D005901 | H40 |
| seizures | HP_0007359 | D012640 | G40.4 |
Agency Specific
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HCPCS
Code | Description |
|---|---|
| J1120 | Injection, acetazolamide sodium, up to 500 mg |
Clinical
Clinical Trials
158 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Altitude sickness | D000532 | EFO_1000782 | T70.29 | 4 | 2 | 3 | 12 | 2 | 22 |
| Obstructive sleep apnea | D020181 | EFO_0003918 | G47.33 | 3 | 9 | 1 | 4 | 1 | 15 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | 3 | 9 | — | 12 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 4 | 5 | 1 | 10 |
| Sleep apnea syndromes | D012891 | HP_0010535 | G47.3 | 1 | 3 | — | 2 | 2 | 7 |
| Glaucoma | D005901 | EFO_0000516 | H40 | — | — | 1 | 3 | 1 | 5 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 3 | 2 | 1 | — | 4 |
| Central sleep apnea | D020182 | — | G47.31 | — | 1 | 1 | 1 | — | 3 |
| Alkalosis | D000471 | HP_0001948 | E87.3 | — | — | 1 | 1 | 1 | 3 |
| Pulmonary edema | D011654 | EFO_1001134 | J81 | — | — | — | 1 | 1 | 2 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pseudotumor cerebri | D011559 | EFO_1001132 | G93.2 | 1 | 1 | 3 | — | — | 4 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 2 | 1 | — | 1 | 4 |
| Retinal artery occlusion | D015356 | EFO_1001154 | H34.1 | — | — | 1 | — | — | 1 |
| Hemodilution | D006438 | — | — | — | — | 1 | — | — | 1 |
| Visual acuity | D014792 | — | — | — | — | 1 | — | — | 1 |
| Fibrinolysis | D005342 | — | — | — | — | 1 | — | — | 1 |
| Neurocysticercosis | D020019 | — | — | — | 1 | 1 | — | — | 1 |
| Intracranial thrombosis | D020767 | — | — | — | — | 1 | — | — | 1 |
| Status epilepticus | D013226 | EFO_0008526 | G41 | — | 1 | 1 | — | — | 1 |
| Landau-kleffner syndrome | D018887 | EFO_1001010 | G40.8 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular edema | D008269 | — | — | — | 3 | — | — | — | 3 |
| Chronic pain | D059350 | HP_0012532 | — | — | 2 | — | — | — | 2 |
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | — | 2 | — | — | — | 2 |
| Diabetic retinopathy | D003930 | EFO_0003770 | — | — | 2 | — | — | — | 2 |
| Brain edema | D001929 | EFO_1000845 | G93.6 | — | 1 | — | — | 1 | 2 |
| Cerebrospinal fluid leak | D065634 | — | G96.0 | — | 2 | — | — | — | 2 |
| Neoplasms | D009369 | — | C80 | 1 | 1 | — | — | — | 2 |
| Melanoma | D008545 | — | — | 2 | 1 | — | — | — | 2 |
| Retinal dystrophies | D058499 | HP_0000556 | — | — | 1 | — | — | — | 1 |
| Compliance | D003187 | — | — | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | 2 | 3 |
| Pure autonomic failure | D054970 | — | — | 1 | — | — | — | — | 1 |
| Orthostatic hypotension | D007024 | — | I95.1 | 1 | — | — | — | — | 1 |
| Glioma | D005910 | EFO_0000520 | — | 1 | — | — | — | — | 1 |
| Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | — | 1 |
| Cognition | D003071 | EFO_0003925 | — | 1 | — | — | — | — | 1 |
| Small cell lung carcinoma | D055752 | — | — | 1 | — | — | — | — | 1 |
| Cocaine-related disorders | D019970 | — | F14 | 1 | — | — | — | — | 1 |
| Pharmacokinetics | D010599 | — | — | 1 | — | — | — | — | 1 |
| Andersen syndrome | D050030 | — | — | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | — | — | — | — | 2 | 2 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 2 | 2 |
| Thalassemia | D013789 | EFO_1001996 | D56 | — | — | — | — | 1 | 1 |
| Kidney calculi | D007669 | EFO_0004253 | N20 | — | — | — | — | 1 | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
| Bartter syndrome | D001477 | Orphanet_112 | E26.81 | — | — | — | — | 1 | 1 |
| Intracranial hypertension | D019586 | EFO_1000992 | — | — | — | — | — | 1 | 1 |
| Angle-closure glaucoma | D015812 | — | — | — | — | — | — | 1 | 1 |
| Headache | D006261 | HP_0002315 | R51 | — | — | — | — | 1 | 1 |
| Ventilator weaning | D015300 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acetazolamide |
| INN | acetazolamide |
| Description | Acetazolamide is a sulfonamide, a member of thiadiazoles and a monocarboxylic acid amide. It has a role as a diuretic, an anticonvulsant and an EC 4.2.1.1 (carbonic anhydrase) inhibitor. It is a conjugate acid of an acetazolamide(1-). It derives from a hydride of a 1,3,4-thiadiazole. |
| Classification | Small molecule |
| Drug class | carbonic anhydrase inhibitors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)Nc1nnc(S(N)(=O)=O)s1 |
Identifiers
| PDB | — |
| CAS-ID | 59-66-5 |
| RxCUI | — |
| ChEMBL ID | CHEMBL20 |
| ChEBI ID | 27690 |
| PubChem CID | 1986 |
| DrugBank | DB00819 |
| UNII ID | O3FX965V0I (ChemIDplus, GSRS) |
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Acetazolamide
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Safety
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2,084 adverse events reported
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