Acenocoumarol
Acenocoumarol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin K epoxide reductase complex subunit 1.
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New Drug Application (NDA)
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pulmonary embolism | D011655 | EFO_0003827 | I26 | — | — | — | 1 | — | 1 |
| Embolism | D004617 | — | — | — | — | — | 1 | — | 1 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | — | — | 1 | — | 1 |
| Thrombosis | D013927 | — | — | — | — | — | 1 | — | 1 |
| Venous thrombosis | D020246 | — | I82.40 | — | — | — | 1 | — | 1 |
| Thromboembolism | D013923 | — | — | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acenocoumarol |
| INN | acenocoumarol |
| Description | Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.
|
| Classification | Small molecule |
| Drug class | anticoagulants (dicumarol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O |
Identifiers
| PDB | — |
| CAS-ID | 152-72-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL397420 |
| ChEBI ID | 53766 |
| PubChem CID | 9052 |
| DrugBank | DB01418 |
| UNII ID | I6WP63U32H (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
VKORC1
VKORC1
Organism
Homo sapiens
Gene name
VKORC1
Gene synonyms
VKOR
NCBI Gene ID
Protein name
vitamin K epoxide reductase complex subunit 1
Protein synonyms
phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, Vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)
Uniprot ID
Mouse ortholog
Vkorc1 (27973)
vitamin K epoxide reductase complex subunit 1 (Q9CRC0)
Variants
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PubMed Central
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Safety
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Adverse Events
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2,687 adverse events reported
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