Acenocoumarol
Acenocoumarol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target vitamin K epoxide reductase complex subunit 1.
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Commercial
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Atrial fibrillation | D001281 | EFO_0000275 | I48.0 | — | 1 | 4 | 2 | 9 | 16 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | — | — | 4 | 1 | 5 |
| Pulmonary embolism | D011655 | HP_0002204 | I26 | — | 1 | 2 | 1 | 1 | 4 |
| Venous thromboembolism | D054556 | EFO_0004286 | I74 | — | 1 | 2 | 2 | — | 4 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | 2 | 3 |
| Aortic valve stenosis | D001024 | HP_0001650 | — | — | — | — | 2 | — | 2 |
| Hemorrhage | D006470 | MP_0001914 | R58 | — | — | — | 1 | — | 1 |
| Aortic valve disease | D000082862 | — | — | — | — | — | 1 | — | 1 |
| Embolism and thrombosis | D016769 | — | — | — | — | — | 1 | — | 1 |
| Vascular ring | D000073872 | — | Q25.45 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neoplasms | D009369 | — | C80 | 1 | — | 1 | — | — | 2 |
| Antiphospholipid syndrome | D016736 | EFO_0002689 | D68.61 | — | — | 1 | — | 1 | 2 |
| Venous thrombosis | D020246 | HP_0004936 | I82.40 | — | 1 | 1 | — | 1 | 2 |
| Intracranial hemorrhages | D020300 | EFO_0000551 | I62 | — | — | 1 | — | — | 1 |
| Hypertensive intracranial hemorrhage | D020299 | — | — | — | — | 1 | — | — | 1 |
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | 1 | — | — | 1 |
| Subdural hematoma | D006408 | HP_0100309 | — | — | — | 1 | — | — | 1 |
| Cerebral intraventricular hemorrhage | D000074042 | — | — | — | — | 1 | — | — | 1 |
| Atrial flutter | D001282 | EFO_0003911 | — | — | — | 1 | — | — | 1 |
| Heart failure | D006333 | HP_0001635 | I50 | — | — | 1 | — | — | 1 |
Indications Phases 2
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Indications Phases 1
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
| Postoperative hemorrhage | D019106 | — | — | — | — | — | — | 1 | 1 |
| Coronary disease | D003327 | — | — | — | — | — | — | 1 | 1 |
| Craniocerebral trauma | D006259 | — | S00 | — | — | — | — | 1 | 1 |
| Length of stay | D007902 | — | — | — | — | — | — | 1 | 1 |
| Stomatognathic diseases | D009057 | — | K08.9 | — | — | — | — | 1 | 1 |
| Periodontal diseases | D010510 | — | K05.6 | — | — | — | — | 1 | 1 |
| Ischemic stroke | D000083242 | — | — | — | — | — | — | 1 | 1 |
| Retinal detachment | D012163 | EFO_0005773 | H33.2 | — | — | — | — | 1 | 1 |
| Embolic stroke | D000083262 | — | — | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Acenocoumarol |
| INN | acenocoumarol |
| Description | Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin). It is a derivative of coumarin and is generic, so is marketed under many brand names worldwide.
|
| Classification | Small molecule |
| Drug class | anticoagulants (dicumarol type) |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC(=O)CC(c1ccc([N+](=O)[O-])cc1)c1c(O)c2ccccc2oc1=O |
Identifiers
| PDB | — |
| CAS-ID | 152-72-7 |
| RxCUI | — |
| ChEMBL ID | CHEMBL397420 |
| ChEBI ID | 53766 |
| PubChem CID | 9052 |
| DrugBank | DB01418 |
| UNII ID | I6WP63U32H (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
VKORC1
VKORC1
Organism
Homo sapiens
Gene name
VKORC1
Gene synonyms
VKOR
NCBI Gene ID
Protein name
vitamin K epoxide reductase complex subunit 1
Protein synonyms
phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, Vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)
Uniprot ID
Mouse ortholog
Vkorc1 (27973)
vitamin K epoxide reductase complex subunit 1 (Q9CRC0)
Variants
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,334 adverse events reported
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