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Drug ReportsAcarbose
Acarbose
Acarbose (acarbose) is an oligosaccharide pharmaceutical. Acarbose was first approved as Precose on 1995-09-06. It is used to treat type 2 diabetes mellitus in the USA. It is known to target maltase-glucoamylase and pancreatic alpha-amylase.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nutritional and metabolic diseasesD009750
endocrine system diseasesD004700
Trade Name
FDA
EMA
Acarbose (discontinued: Acarbose, Precose)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Acarbose
Tradename
Company
Number
Date
Products
PRECOSEBayerN-020482 DISCN1995-09-06
3 products, RLD
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Labels
FDA
EMA
Brand Name
Status
Last Update
acarboseANDA2024-11-18
precoseNew Drug Application2014-05-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
type 2 diabetes mellitusEFO_0001360D003924E11
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
A: Alimentary tract and metabolism drugs
— A10: Drugs used in diabetes
— A10B: Blood glucose lowering drugs, excl. insulins
— A10BD: Combinations of oral blood glucose lowering drugs
— A10BD17: Metformin and acarbose
— A10BF: Alpha glucosidase inhibitors, blood glucose lowering
— A10BF01: Acarbose
HCPCS
No data
Clinical
No data
Drug
General
Drug common nameAcarbose
INNacarbose
Description
(2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol is a glycoside and an amino cyclitol.
Classification
Oligosaccharide
Drug class—
Image (chem structure or protein)Loading
Structure (InChI/SMILES or Protein Sequence)
C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O
Identifiers
PDB—
CAS-ID56180-94-0
RxCUI—
ChEMBL IDCHEMBL1566
ChEBI ID—
PubChem CID444254
DrugBankDB00284
UNII IDT58MSI464G (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
MGAM
MGAM
AMY2A
AMY2A
Organism
Homo sapiens
Gene name
MGAM
Gene synonyms
MGA, MGAML
NCBI Gene ID
8972
Protein name
maltase-glucoamylase
Protein synonyms
Alpha-1,4-glucosidase, brush border hydrolase, maltase-glucoamylase (alpha-glucosidase), maltase-glucoamylase, intestinal
Uniprot ID
Q86UM5
Mouse ortholog
Mgam (232714)
maltase-glucoamylase (A0A571BF69)
Variants
No data
Financial
Revenue by drug
$
€
£
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No data
Estimated US medical usage
Acarbose
Total medical expenditures per year (USD, in millions)
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Trends
No data
Safety
Black-box Warning
No Black-box warning
Adverse Events
0 adverse events reported
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