Acarbose - PharmaKB

Acarbose

Acarbose (acarbose) is an oligosaccharide pharmaceutical. Acarbose was first approved as Precose on 1995-09-06. It is used to treat type 2 diabetes mellitus in the USA. It is known to target maltase-glucoamylase and pancreatic alpha-amylase.

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FDA approval date

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Commercial

Therapeutic Areas

Therapeutic Area	MeSH
nutritional and metabolic diseases	D009750
endocrine system diseases	D004700

Trade Name

FDA

EMA

Acarbose (discontinued: Acarbose, Precose)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Acarbose

Tradename	Company	Number	Date	Products
PRECOSE	Bayer	N-020482 DISCN	1995-09-06	3 products, RLD

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Labels

FDA

EMA

Brand Name	Status	Last Update
acarbose	ANDA	2025-01-20
precose	New Drug Application	2014-05-29

Indications

FDA

EMA

Indication	Ontology	MeSH	ICD-10
type 2 diabetes mellitus	EFO_0001360	D003924	E11

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

A: Alimentary tract and metabolism drugs

— A10: Drugs used in diabetes

— A10B: Blood glucose lowering drugs, excl. insulins

— A10BD: Combinations of oral blood glucose lowering drugs

— A10BD17: Metformin and acarbose

— A10BF: Alpha glucosidase inhibitors, blood glucose lowering

— A10BF01: Acarbose

HCPCS

No data

Clinical

No data

Drug

General

Drug common name	Acarbose
INN	acarbose
Description	(2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol is a glycoside and an amino cyclitol.
Classification	Oligosaccharide
Drug class	—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	C[C@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@H](O[C@@H]3[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]3O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1N[C@H]1C=C(CO)[C@@H](O)[C@H](O)[C@H]1O

Identifiers

PDB	—
CAS-ID	56180-94-0
RxCUI	—
ChEMBL ID	CHEMBL1566
ChEBI ID	—
PubChem CID	444254
DrugBank	DB00284
UNII ID	T58MSI464G (ChemIDplus, GSRS)

Target

Agency Approved

No data

Alternate

AMY2A

Organism

Homo sapiens

Gene name

AMY2A

Gene synonyms

NCBI Gene ID

279

Protein name

pancreatic alpha-amylase

Protein synonyms

1,4-alpha-D-glucan glucanohydrolase, amylase alpha 2A (pancreatic), glycogenase, pancreatic amylase alpha 2A

Uniprot ID

P04746

Mouse ortholog

—

Variants

No data

Financial

Revenue by drug

€

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No data

Estimated US medical usage

Acarbose

Total medical expenditures per year (USD, in millions)

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Trends

No data

Safety

Black-box Warning

No Black-box warning

Adverse Events

0 adverse events reported